【Objective】 To investigate the changes in left wrist pulse wave transit time （PTT） in patients with hypertension， as well as the effects of serological indicators and unhealthy lifestyle. 【Methods】 We recruited 321 hypertensive patients admitted to Chinese PLA General Hospital Hainan Branch from June 2020 to April 2021 and divided them into two groups according to the simple randomization method. Totally 135 patients in the control group drank 20 mL of water after getting up in the morning and 186 patients in the observation group took the nifedipine controlled release tablets on the basis of the control group. A smart watch was used to collect the PTT at 0.5 h， 4.5 h， and 8.5 h after taking the medicine （drinking water） for the two groups. Repeated measurement analysis of variance was used to observe the influences of the time， interaction effect， and medicine on PTT. The data of gender， age， height， weight， left arm circumference， left arm length， resting heart rate， smoking， and alcohol drinking were collected. Fasting blood of 4 mL was collected to detect indicators such as fasting blood glucose （FBG）， total cholesterol （TC）， triglyceride （TG）， and uric acid （UA） to analyze possible factors affecting PTT. 【Results】 The time effect was statistically significant （F=12.065， P<0.001）， while the interaction effect was not （F=0.089， P=0.915）. There was no statistically significant difference between the two groups （F=2.074， P=0.155）. FBG， TC， TG， resting heart rate， and limited alcohol drinking differed significantly （P<0.05）. 【Conclusion】 PTT gradually shortens with time， and it has no significant relationship with antihypertensive drugs， but may be related to FBG， TC， TG， resting heart rate， alcohol drinking and other indicators.

Objective To explore the curative effect of percutaneous cavity injection for the treatment of drug resistant pulmonary tuberculosis guided by color Doppler ultrasound.Methods Ninety-six bacterial culture positive patients with drug resistant pulmonary tuberculosis were randomly divided into treatment group(n =48) and control group (n =48).Patients in both groupswere given systemic anti tuberculosis therapy,and those who in the treatment group were given extra percutaneous cavity injection guided by color Doppler ultrasound.Results After 3 months of treatment,the sputum negative conversation rate,X-ray absorption rate,cavity closure rate,and cavity efficiency rate of the treatment group were 56.3％ (27/48),81.3％ (39/48),58.3％ (28/48) and 75.0％ (36/48) respectively,higher than those of the control group 35.4％ (17/48),62.5％ (30/48),37.5％ (18/48) and 50.0％ (24/48) respectively),and the differences were statistically significant(x2 =4.20,P =0.02 4 ; x2 =4.17,P =0.041; x2 =9.58,P =0.004 ; x2 =6.40,P=0.020).After 12 months of treatment,the sputum negative conversation rate,cavity closure rate,cavity efficiency rate of the treatment group were 93.8％ (45/48),83.3％ (40/48),95.8％ (46/48) respectively,higher than those of control group(77.1％ (37/48),62.5％ (30/48) and 81.3％ (39/48)),and there were significant differences between two groups (x2 =5.35,5.27,5.03 ; P =0.040,0.038,0.025) ; the X-ray absorption rate of the treatment group was 93.8％ (45/48),higher than that of ciontrol group (83.3％ (40/48)),but there was no significant difference between two groups(x2 =2.56,P =0.199).Conclusion It is very effective to treat drug resistant pulmonary tuberculosis using percutaneous cavity injection guided by Color Doppler Ultrasound.No obvious complications or adverse reactions have been observed so far.