Background: This study established sex-specific reference intervals (RIs) for hematological parameters, including the monocyte distribution width (MDW), in Korean adults and assessed the need for separate RIs according to sex in older adults. Methods: Hematological parameters were measured using a DxH 900 hematology analyzer (Beckman Coulter, USA) on 328 peripheral blood samples from 124 men and 204 women aged 19–93 years. Results: The RIs for white blood cells, red blood cells (RBCs), Hb, Hct, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, monocyte percentage, and neutrophil, eosinophil, lympho­cyte, and monocyte counts differed significantly by sex (P<0.05). Mean corpuscular volume was significantly positively associated with age, whereas RBC and platelet counts were significantly negatively correlated with age in both men and women. Age-based analysis revealed significant shifts in the RBC parameters beginning at 60 years of age in men and 70 years of age in women. The MDW did not show significant differences according to sex or age. Conclusions This study supports the use of sex-specific RIs and highlights the importance of considering age when interpreting results regarding hematological parameters in clinical practice.

Background: This study established sex-specific reference intervals (RIs) for hematological parameters, including the monocyte distribution width (MDW), in Korean adults and assessed the need for separate RIs according to sex in older adults. Methods: Hematological parameters were measured using a DxH 900 hematology analyzer (Beckman Coulter, USA) on 328 peripheral blood samples from 124 men and 204 women aged 19–93 years. Results: The RIs for white blood cells, red blood cells (RBCs), Hb, Hct, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, monocyte percentage, and neutrophil, eosinophil, lympho­cyte, and monocyte counts differed significantly by sex (P<0.05). Mean corpuscular volume was significantly positively associated with age, whereas RBC and platelet counts were significantly negatively correlated with age in both men and women. Age-based analysis revealed significant shifts in the RBC parameters beginning at 60 years of age in men and 70 years of age in women. The MDW did not show significant differences according to sex or age. Conclusions This study supports the use of sex-specific RIs and highlights the importance of considering age when interpreting results regarding hematological parameters in clinical practice.

Background: This study established sex-specific reference intervals (RIs) for hematological parameters, including the monocyte distribution width (MDW), in Korean adults and assessed the need for separate RIs according to sex in older adults. Methods: Hematological parameters were measured using a DxH 900 hematology analyzer (Beckman Coulter, USA) on 328 peripheral blood samples from 124 men and 204 women aged 19–93 years. Results: The RIs for white blood cells, red blood cells (RBCs), Hb, Hct, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, monocyte percentage, and neutrophil, eosinophil, lympho­cyte, and monocyte counts differed significantly by sex (P<0.05). Mean corpuscular volume was significantly positively associated with age, whereas RBC and platelet counts were significantly negatively correlated with age in both men and women. Age-based analysis revealed significant shifts in the RBC parameters beginning at 60 years of age in men and 70 years of age in women. The MDW did not show significant differences according to sex or age. Conclusions This study supports the use of sex-specific RIs and highlights the importance of considering age when interpreting results regarding hematological parameters in clinical practice.

Background: This study established sex-specific reference intervals (RIs) for hematological parameters, including the monocyte distribution width (MDW), in Korean adults and assessed the need for separate RIs according to sex in older adults. Methods: Hematological parameters were measured using a DxH 900 hematology analyzer (Beckman Coulter, USA) on 328 peripheral blood samples from 124 men and 204 women aged 19–93 years. Results: The RIs for white blood cells, red blood cells (RBCs), Hb, Hct, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, monocyte percentage, and neutrophil, eosinophil, lympho­cyte, and monocyte counts differed significantly by sex (P<0.05). Mean corpuscular volume was significantly positively associated with age, whereas RBC and platelet counts were significantly negatively correlated with age in both men and women. Age-based analysis revealed significant shifts in the RBC parameters beginning at 60 years of age in men and 70 years of age in women. The MDW did not show significant differences according to sex or age. Conclusions This study supports the use of sex-specific RIs and highlights the importance of considering age when interpreting results regarding hematological parameters in clinical practice.

Background: This study established sex-specific reference intervals (RIs) for hematological parameters, including the monocyte distribution width (MDW), in Korean adults and assessed the need for separate RIs according to sex in older adults. Methods: Hematological parameters were measured using a DxH 900 hematology analyzer (Beckman Coulter, USA) on 328 peripheral blood samples from 124 men and 204 women aged 19–93 years. Results: The RIs for white blood cells, red blood cells (RBCs), Hb, Hct, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, monocyte percentage, and neutrophil, eosinophil, lympho­cyte, and monocyte counts differed significantly by sex (P<0.05). Mean corpuscular volume was significantly positively associated with age, whereas RBC and platelet counts were significantly negatively correlated with age in both men and women. Age-based analysis revealed significant shifts in the RBC parameters beginning at 60 years of age in men and 70 years of age in women. The MDW did not show significant differences according to sex or age. Conclusions This study supports the use of sex-specific RIs and highlights the importance of considering age when interpreting results regarding hematological parameters in clinical practice.

Autoimmune diseases have been observed in patients with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN); however, acquired hemophilia, which can develop owing to autoimmune diseases, has not yet been reported SJS/TEN patients. A 74-yearold male patient, who had been treated for SJS after allopurinol exposure, was referred to our clinic due to hypotension and mucosal erosions. He was suspected to have septic shock due to widespread mucosal involvement caused by SJS, which improved after 1week of intensive conservative treatment that included antibiotics and systemic corticosteroids. However, a rapid increase in prothrombin time (> 60 seconds) and activated partial thromboplastin time (> 120 seconds) was confirmed, and the mixture of the 2materials did not improve decreased factor VIII activity (18.7%). The patient was diagnosed with acquired hemophilia, which was probably associated with SJS. In this case, acquired hemophilia, a fatal and rare autoimmune disease, occurred concurrently with SJS.

Autoimmune diseases have been observed in patients with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN); however, acquired hemophilia, which can develop owing to autoimmune diseases, has not yet been reported SJS/TEN patients. A 74-yearold male patient, who had been treated for SJS after allopurinol exposure, was referred to our clinic due to hypotension and mucosal erosions. He was suspected to have septic shock due to widespread mucosal involvement caused by SJS, which improved after 1week of intensive conservative treatment that included antibiotics and systemic corticosteroids. However, a rapid increase in prothrombin time (> 60 seconds) and activated partial thromboplastin time (> 120 seconds) was confirmed, and the mixture of the 2materials did not improve decreased factor VIII activity (18.7%). The patient was diagnosed with acquired hemophilia, which was probably associated with SJS. In this case, acquired hemophilia, a fatal and rare autoimmune disease, occurred concurrently with SJS.

Autoimmune diseases have been observed in patients with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN); however, acquired hemophilia, which can develop owing to autoimmune diseases, has not yet been reported SJS/TEN patients. A 74-yearold male patient, who had been treated for SJS after allopurinol exposure, was referred to our clinic due to hypotension and mucosal erosions. He was suspected to have septic shock due to widespread mucosal involvement caused by SJS, which improved after 1week of intensive conservative treatment that included antibiotics and systemic corticosteroids. However, a rapid increase in prothrombin time (> 60 seconds) and activated partial thromboplastin time (> 120 seconds) was confirmed, and the mixture of the 2materials did not improve decreased factor VIII activity (18.7%). The patient was diagnosed with acquired hemophilia, which was probably associated with SJS. In this case, acquired hemophilia, a fatal and rare autoimmune disease, occurred concurrently with SJS.

Autoimmune diseases have been observed in patients with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN); however, acquired hemophilia, which can develop owing to autoimmune diseases, has not yet been reported SJS/TEN patients. A 74-yearold male patient, who had been treated for SJS after allopurinol exposure, was referred to our clinic due to hypotension and mucosal erosions. He was suspected to have septic shock due to widespread mucosal involvement caused by SJS, which improved after 1week of intensive conservative treatment that included antibiotics and systemic corticosteroids. However, a rapid increase in prothrombin time (> 60 seconds) and activated partial thromboplastin time (> 120 seconds) was confirmed, and the mixture of the 2materials did not improve decreased factor VIII activity (18.7%). The patient was diagnosed with acquired hemophilia, which was probably associated with SJS. In this case, acquired hemophilia, a fatal and rare autoimmune disease, occurred concurrently with SJS.

Autoimmune diseases have been observed in patients with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN); however, acquired hemophilia, which can develop owing to autoimmune diseases, has not yet been reported SJS/TEN patients. A 74-yearold male patient, who had been treated for SJS after allopurinol exposure, was referred to our clinic due to hypotension and mucosal erosions. He was suspected to have septic shock due to widespread mucosal involvement caused by SJS, which improved after 1week of intensive conservative treatment that included antibiotics and systemic corticosteroids. However, a rapid increase in prothrombin time (> 60 seconds) and activated partial thromboplastin time (> 120 seconds) was confirmed, and the mixture of the 2materials did not improve decreased factor VIII activity (18.7%). The patient was diagnosed with acquired hemophilia, which was probably associated with SJS. In this case, acquired hemophilia, a fatal and rare autoimmune disease, occurred concurrently with SJS.