Purpose: This study aimed to develop a comprehensive practical guide for enteral nutrition (EN) designed to enhance patient safety and reduce complications in Korea. Under the leadership of the Korean Society for Parenteral and Enteral Nutrition (KSPEN), the initiative sought to standardize EN procedures, improve decision-making, and promote effective multidisciplinary communication. Methods: The KSPEN EN committee identified key questions related to EN practices and organized them into seven sections such as prescribing, delivery route selection, formula preparation, administration, and quality management. Twenty-one experts, selected based on their expertise, conducted a thorough literature review to formulate evidence-based recommendations. Drafts underwent peer review both within and across disciplines, with final revisions completed by the KSPEN Guideline Committee. The guide, which will be published in three installments, addresses critical elements of EN therapy and safety protocols. Results: The practical guide recommends that EN orders include detailed elements and advocates the use of electronic medical records for communication. Standardized prescription forms and supplementary safety measures are outlined. Review frequency is adjusted according to patient condition—daily for critically ill or unstable patients and as dictated by institutional protocols for stable patients. Evidence indicates that adherence to these protocols reduces mortality, complications, and prescription errors. Conclusion The KSPEN practical guide offers a robust framework for the safe delivery of EN tailored to Korea’s healthcare context. It emphasizes standardized protocols and interdisciplinary collaboration to improve nutritional outcomes, patient safety, and operational efficiency. Rigorous implementation and monitoring of adherence are critical for its success.

Purpose: This study aimed to develop a comprehensive practical guide for enteral nutrition (EN) designed to enhance patient safety and reduce complications in Korea. Under the leadership of the Korean Society for Parenteral and Enteral Nutrition (KSPEN), the initiative sought to standardize EN procedures, improve decision-making, and promote effective multidisciplinary communication. Methods: The KSPEN EN committee identified key questions related to EN practices and organized them into seven sections such as prescribing, delivery route selection, formula preparation, administration, and quality management. Twenty-one experts, selected based on their expertise, conducted a thorough literature review to formulate evidence-based recommendations. Drafts underwent peer review both within and across disciplines, with final revisions completed by the KSPEN Guideline Committee. The guide, which will be published in three installments, addresses critical elements of EN therapy and safety protocols. Results: The practical guide recommends that EN orders include detailed elements and advocates the use of electronic medical records for communication. Standardized prescription forms and supplementary safety measures are outlined. Review frequency is adjusted according to patient condition—daily for critically ill or unstable patients and as dictated by institutional protocols for stable patients. Evidence indicates that adherence to these protocols reduces mortality, complications, and prescription errors. Conclusion The KSPEN practical guide offers a robust framework for the safe delivery of EN tailored to Korea’s healthcare context. It emphasizes standardized protocols and interdisciplinary collaboration to improve nutritional outcomes, patient safety, and operational efficiency. Rigorous implementation and monitoring of adherence are critical for its success.

Purpose: This study aimed to develop a comprehensive practical guide for enteral nutrition (EN) designed to enhance patient safety and reduce complications in Korea. Under the leadership of the Korean Society for Parenteral and Enteral Nutrition (KSPEN), the initiative sought to standardize EN procedures, improve decision-making, and promote effective multidisciplinary communication. Methods: The KSPEN EN committee identified key questions related to EN practices and organized them into seven sections such as prescribing, delivery route selection, formula preparation, administration, and quality management. Twenty-one experts, selected based on their expertise, conducted a thorough literature review to formulate evidence-based recommendations. Drafts underwent peer review both within and across disciplines, with final revisions completed by the KSPEN Guideline Committee. The guide, which will be published in three installments, addresses critical elements of EN therapy and safety protocols. Results: The practical guide recommends that EN orders include detailed elements and advocates the use of electronic medical records for communication. Standardized prescription forms and supplementary safety measures are outlined. Review frequency is adjusted according to patient condition—daily for critically ill or unstable patients and as dictated by institutional protocols for stable patients. Evidence indicates that adherence to these protocols reduces mortality, complications, and prescription errors. Conclusion The KSPEN practical guide offers a robust framework for the safe delivery of EN tailored to Korea’s healthcare context. It emphasizes standardized protocols and interdisciplinary collaboration to improve nutritional outcomes, patient safety, and operational efficiency. Rigorous implementation and monitoring of adherence are critical for its success.

Purpose: This study aimed to develop a comprehensive practical guide for enteral nutrition (EN) designed to enhance patient safety and reduce complications in Korea. Under the leadership of the Korean Society for Parenteral and Enteral Nutrition (KSPEN), the initiative sought to standardize EN procedures, improve decision-making, and promote effective multidisciplinary communication. Methods: The KSPEN EN committee identified key questions related to EN practices and organized them into seven sections such as prescribing, delivery route selection, formula preparation, administration, and quality management. Twenty-one experts, selected based on their expertise, conducted a thorough literature review to formulate evidence-based recommendations. Drafts underwent peer review both within and across disciplines, with final revisions completed by the KSPEN Guideline Committee. The guide, which will be published in three installments, addresses critical elements of EN therapy and safety protocols. Results: The practical guide recommends that EN orders include detailed elements and advocates the use of electronic medical records for communication. Standardized prescription forms and supplementary safety measures are outlined. Review frequency is adjusted according to patient condition—daily for critically ill or unstable patients and as dictated by institutional protocols for stable patients. Evidence indicates that adherence to these protocols reduces mortality, complications, and prescription errors. Conclusion The KSPEN practical guide offers a robust framework for the safe delivery of EN tailored to Korea’s healthcare context. It emphasizes standardized protocols and interdisciplinary collaboration to improve nutritional outcomes, patient safety, and operational efficiency. Rigorous implementation and monitoring of adherence are critical for its success.

Purpose: This study aimed to develop a comprehensive practical guide for enteral nutrition (EN) designed to enhance patient safety and reduce complications in Korea. Under the leadership of the Korean Society for Parenteral and Enteral Nutrition (KSPEN), the initiative sought to standardize EN procedures, improve decision-making, and promote effective multidisciplinary communication. Methods: The KSPEN EN committee identified key questions related to EN practices and organized them into seven sections such as prescribing, delivery route selection, formula preparation, administration, and quality management. Twenty-one experts, selected based on their expertise, conducted a thorough literature review to formulate evidence-based recommendations. Drafts underwent peer review both within and across disciplines, with final revisions completed by the KSPEN Guideline Committee. The guide, which will be published in three installments, addresses critical elements of EN therapy and safety protocols. Results: The practical guide recommends that EN orders include detailed elements and advocates the use of electronic medical records for communication. Standardized prescription forms and supplementary safety measures are outlined. Review frequency is adjusted according to patient condition—daily for critically ill or unstable patients and as dictated by institutional protocols for stable patients. Evidence indicates that adherence to these protocols reduces mortality, complications, and prescription errors. Conclusion The KSPEN practical guide offers a robust framework for the safe delivery of EN tailored to Korea’s healthcare context. It emphasizes standardized protocols and interdisciplinary collaboration to improve nutritional outcomes, patient safety, and operational efficiency. Rigorous implementation and monitoring of adherence are critical for its success.

Purpose: This quasi-experimental study used a non-equivalent control group pretest-posttest design with clinical nurses to develop a compassion improvement program and verify its effects on compassion competence and empathic communication. Methods: The Triandis Interpersonal Behavior model (Triandis, 1980) was used as a theoretical framework, and a compassion improvement program was developed based on the ADDIE model. The experimental treatment in the program was conducted for 120 minutes per session, once a week, for a total of six sessions. The data collection and research period ranged from September 7 to November 16. It involved a pre-survey of measured variables, six sessions of experimental treatment, a post-survey, and a follow-up survey in sequence. The collected data were analyzed using the statistical program SPSS/WIN 25.0 and then based on a t-test and repeated measures ANOVA to verify the effectiveness of the program. Results: Clinical nurses participating in the compassion improvement program showed improved compassion competence (F=8.00, p=.001) due to the cultivation of insight, sensitivity, and communication skills. In addition, the improvement in attentive listening (F=3.32, p=.024) indicated that the program was partially effective in empathic communication. Conclusion The compassion improvement program for clinical nurses, which was developed in this study, is expected to be useful in nursing practice. In other words, the compassion improvement program may contribute to creating a positive atmosphere in the workplace for nurses and an empathic relationship between nurses and healthcare recipients through improvement in the compassion competence of nurses. If the compassion improvement program is continuously implemented as a facilitating condition, it will greatly help prevent the turnover of clinical nurses, assist them in adapting to hospital life, and enhance the quality of nursing care.

Purpose: The purpose of this study was to explore and assess the experiences of cancer patients and their caregivers who had been admitted to comprehensive nursing care service wards. Methods: Data were collected from 10 patients and 10 caregivers by in-depth interviews. The data were analyzed using content analysis of Downe-Wamboldt. Results: Three categories and seven subcategories were extracted. 1) Realizing institutional limitations of comprehensive nursing care service: ‘Wishing for precise operating systems based on patient severity,’ ‘Anticipating active caregiver participation in treatment process,’ ‘Requiring a countermeasure for safety accidents,’ 2) Professional nursing service which provides relief: ‘Patient-centered professional nursing service,’ ‘Inpatient service that provides relief for patients and caregivers,’ 3) Anticipating continuous use of the service: ‘Inpatient service which users are willing to reuse,’ ‘Wishing for expansion and reinforcement of the service.’ Conclusion Cancer patients and their caregivers experienced institutional limitations while satisfied with professional nursing service and willing to reuse the service. To improve this situation, institutional support such as separate wards for severe patients, measures for active caregiver participation and prevention of safety accidents, and adequate staffing would be helpful for relatively severe level cancer patients and their caregivers.

Purpose: This quasi-experimental study used a non-equivalent control group pretest-posttest design with clinical nurses to develop a compassion improvement program and verify its effects on compassion competence and empathic communication. Methods: The Triandis Interpersonal Behavior model (Triandis, 1980) was used as a theoretical framework, and a compassion improvement program was developed based on the ADDIE model. The experimental treatment in the program was conducted for 120 minutes per session, once a week, for a total of six sessions. The data collection and research period ranged from September 7 to November 16. It involved a pre-survey of measured variables, six sessions of experimental treatment, a post-survey, and a follow-up survey in sequence. The collected data were analyzed using the statistical program SPSS/WIN 25.0 and then based on a t-test and repeated measures ANOVA to verify the effectiveness of the program. Results: Clinical nurses participating in the compassion improvement program showed improved compassion competence (F=8.00, p=.001) due to the cultivation of insight, sensitivity, and communication skills. In addition, the improvement in attentive listening (F=3.32, p=.024) indicated that the program was partially effective in empathic communication. Conclusion The compassion improvement program for clinical nurses, which was developed in this study, is expected to be useful in nursing practice. In other words, the compassion improvement program may contribute to creating a positive atmosphere in the workplace for nurses and an empathic relationship between nurses and healthcare recipients through improvement in the compassion competence of nurses. If the compassion improvement program is continuously implemented as a facilitating condition, it will greatly help prevent the turnover of clinical nurses, assist them in adapting to hospital life, and enhance the quality of nursing care.

Purpose: This quasi-experimental study used a non-equivalent control group pretest-posttest design with clinical nurses to develop a compassion improvement program and verify its effects on compassion competence and empathic communication. Methods: The Triandis Interpersonal Behavior model (Triandis, 1980) was used as a theoretical framework, and a compassion improvement program was developed based on the ADDIE model. The experimental treatment in the program was conducted for 120 minutes per session, once a week, for a total of six sessions. The data collection and research period ranged from September 7 to November 16. It involved a pre-survey of measured variables, six sessions of experimental treatment, a post-survey, and a follow-up survey in sequence. The collected data were analyzed using the statistical program SPSS/WIN 25.0 and then based on a t-test and repeated measures ANOVA to verify the effectiveness of the program. Results: Clinical nurses participating in the compassion improvement program showed improved compassion competence (F=8.00, p=.001) due to the cultivation of insight, sensitivity, and communication skills. In addition, the improvement in attentive listening (F=3.32, p=.024) indicated that the program was partially effective in empathic communication. Conclusion The compassion improvement program for clinical nurses, which was developed in this study, is expected to be useful in nursing practice. In other words, the compassion improvement program may contribute to creating a positive atmosphere in the workplace for nurses and an empathic relationship between nurses and healthcare recipients through improvement in the compassion competence of nurses. If the compassion improvement program is continuously implemented as a facilitating condition, it will greatly help prevent the turnover of clinical nurses, assist them in adapting to hospital life, and enhance the quality of nursing care.

Purpose: Vascular endothelial growth factor tyrosine kinase inhibitors (TKIs) have been the standard of care for advanced and metastatic clear cell renal cell carcinoma (ccRCC). However, the therapeutic effect of TKI monotherapy remains unsatisfactory given the high rates of acquired resistance to TKI therapy despite favorable initial tumor response. Materials and Methods: To define the TKI-resistance mechanism and identify new therapeutic target for TKI-resistant ccRCC, an integrative differential gene expression analysis was performed using acquired resistant cohort and a public dataset. Sunitinib-resistant RCC cell lines were established and used to test their malignant behaviors of TKI resistance through in vitro and in vivo studies. Immunohistochemistry was conducted to compare expression between the tumor and normal kidney and verify expression of pathway-related proteins. Results: Integrated differential gene expression analysis revealed increased interferon-induced transmembrane protein 3 (IFITM3) expression in post-TKI samples. IFITM3 expression was increased in ccRCC compared with the normal kidney. TKI-resistant RCC cells showed high expression of IFITM3 compared with TKI-sensitive cells and displayed aggressive biologic features such as higher proliferative ability, clonogenic survival, migration, and invasion while being treated with sunitinib. These aggressive features were suppressed by the inhibition of IFITM3 expression and promoted by IFITM3 overexpression, and these findings were confirmed in a xenograft model. IFITM3-mediated TKI resistance was associated with the activation of TRAF6 and MAPK/AP-1 pathways. Conclusions These results demonstrate IFITM3-mediated activation of the TRAF6/MAPK/AP-1 pathways as a mechanism of acquired TKI resistance, and suggest IFITM3 as a new target for TKI-resistant ccRCC.