1.Urine Leukocyte Counts for Differentiating Asymptomatic Bacteriuria From Urinary Tract Infection and Predicting Secondary Bacteremia
Yongseop LEE ; JongHoon HYUN ; Je Eun SONG ; Hyo Won PARK ; I Ji YUN ; Yee Gyung KWAK ; Yong Chan KIM
Journal of Korean Medical Science 2025;40(9):e30-
Background:
Differentiating between asymptomatic bacteriuria (ASB) and urinary tract infection (UTI) is difficult in patients who have difficulty communicating their symptoms.This study aimed to evaluate the diagnostic accuracy of urine leukocytes in distinguishing between UTI and ASB, and the clinical outcomes of patients with UTI according to the degree of pyuria.
Methods:
This retrospective cohort study included patients with positive urine cultures between July 2022 and June 2023 at two hospitals. UTI and ASB were diagnosed through a comprehensive review of medical records. We evaluated the differences in urine leukocyte counts between patients with UTI and ASB. The diagnostic performance of urine leukocytes to differentiate between UTI and ASB was evaluated. To investigate the clinical outcomes based on the degree of pyuria, we classified patients with upper UTI according to their urine leukocyte counts.
Results:
Of the 1,793 eligible patients with bacteriuria included, 1,464 had UTI and 329 had ASB. Patients with UTI had higher urinary leukocytes than patients with ASB did (490.4 vs.123.5 cells/µL; P < 0.001). The area under the receiver operating characteristic curve was 0.702 for discriminating between ASB and UTI. The optimal urine leukocyte cutoff was 195.35 cells/µL, with a sensitivity and specificity of 0.70 and 0.60, respectively. A sequential rise in secondary bacteremia rate was observed according to an increase in urine leukocytes in patients with upper UTI, whereas in-hospital mortality showed no corresponding trend.
Conclusion
Urine leukocyte counts could be used to predict UTI occurrence and bacteremia secondary to UTI. Higher degrees of pyuria were associated with bacteremia but not with mortality. Urine leukocyte counts can provide additive information for patients with bacteriuria with vague symptoms.
2.Urine Leukocyte Counts for Differentiating Asymptomatic Bacteriuria From Urinary Tract Infection and Predicting Secondary Bacteremia
Yongseop LEE ; JongHoon HYUN ; Je Eun SONG ; Hyo Won PARK ; I Ji YUN ; Yee Gyung KWAK ; Yong Chan KIM
Journal of Korean Medical Science 2025;40(9):e30-
Background:
Differentiating between asymptomatic bacteriuria (ASB) and urinary tract infection (UTI) is difficult in patients who have difficulty communicating their symptoms.This study aimed to evaluate the diagnostic accuracy of urine leukocytes in distinguishing between UTI and ASB, and the clinical outcomes of patients with UTI according to the degree of pyuria.
Methods:
This retrospective cohort study included patients with positive urine cultures between July 2022 and June 2023 at two hospitals. UTI and ASB were diagnosed through a comprehensive review of medical records. We evaluated the differences in urine leukocyte counts between patients with UTI and ASB. The diagnostic performance of urine leukocytes to differentiate between UTI and ASB was evaluated. To investigate the clinical outcomes based on the degree of pyuria, we classified patients with upper UTI according to their urine leukocyte counts.
Results:
Of the 1,793 eligible patients with bacteriuria included, 1,464 had UTI and 329 had ASB. Patients with UTI had higher urinary leukocytes than patients with ASB did (490.4 vs.123.5 cells/µL; P < 0.001). The area under the receiver operating characteristic curve was 0.702 for discriminating between ASB and UTI. The optimal urine leukocyte cutoff was 195.35 cells/µL, with a sensitivity and specificity of 0.70 and 0.60, respectively. A sequential rise in secondary bacteremia rate was observed according to an increase in urine leukocytes in patients with upper UTI, whereas in-hospital mortality showed no corresponding trend.
Conclusion
Urine leukocyte counts could be used to predict UTI occurrence and bacteremia secondary to UTI. Higher degrees of pyuria were associated with bacteremia but not with mortality. Urine leukocyte counts can provide additive information for patients with bacteriuria with vague symptoms.
3.Urine Leukocyte Counts for Differentiating Asymptomatic Bacteriuria From Urinary Tract Infection and Predicting Secondary Bacteremia
Yongseop LEE ; JongHoon HYUN ; Je Eun SONG ; Hyo Won PARK ; I Ji YUN ; Yee Gyung KWAK ; Yong Chan KIM
Journal of Korean Medical Science 2025;40(9):e30-
Background:
Differentiating between asymptomatic bacteriuria (ASB) and urinary tract infection (UTI) is difficult in patients who have difficulty communicating their symptoms.This study aimed to evaluate the diagnostic accuracy of urine leukocytes in distinguishing between UTI and ASB, and the clinical outcomes of patients with UTI according to the degree of pyuria.
Methods:
This retrospective cohort study included patients with positive urine cultures between July 2022 and June 2023 at two hospitals. UTI and ASB were diagnosed through a comprehensive review of medical records. We evaluated the differences in urine leukocyte counts between patients with UTI and ASB. The diagnostic performance of urine leukocytes to differentiate between UTI and ASB was evaluated. To investigate the clinical outcomes based on the degree of pyuria, we classified patients with upper UTI according to their urine leukocyte counts.
Results:
Of the 1,793 eligible patients with bacteriuria included, 1,464 had UTI and 329 had ASB. Patients with UTI had higher urinary leukocytes than patients with ASB did (490.4 vs.123.5 cells/µL; P < 0.001). The area under the receiver operating characteristic curve was 0.702 for discriminating between ASB and UTI. The optimal urine leukocyte cutoff was 195.35 cells/µL, with a sensitivity and specificity of 0.70 and 0.60, respectively. A sequential rise in secondary bacteremia rate was observed according to an increase in urine leukocytes in patients with upper UTI, whereas in-hospital mortality showed no corresponding trend.
Conclusion
Urine leukocyte counts could be used to predict UTI occurrence and bacteremia secondary to UTI. Higher degrees of pyuria were associated with bacteremia but not with mortality. Urine leukocyte counts can provide additive information for patients with bacteriuria with vague symptoms.
4.Urine Leukocyte Counts for Differentiating Asymptomatic Bacteriuria From Urinary Tract Infection and Predicting Secondary Bacteremia
Yongseop LEE ; JongHoon HYUN ; Je Eun SONG ; Hyo Won PARK ; I Ji YUN ; Yee Gyung KWAK ; Yong Chan KIM
Journal of Korean Medical Science 2025;40(9):e30-
Background:
Differentiating between asymptomatic bacteriuria (ASB) and urinary tract infection (UTI) is difficult in patients who have difficulty communicating their symptoms.This study aimed to evaluate the diagnostic accuracy of urine leukocytes in distinguishing between UTI and ASB, and the clinical outcomes of patients with UTI according to the degree of pyuria.
Methods:
This retrospective cohort study included patients with positive urine cultures between July 2022 and June 2023 at two hospitals. UTI and ASB were diagnosed through a comprehensive review of medical records. We evaluated the differences in urine leukocyte counts between patients with UTI and ASB. The diagnostic performance of urine leukocytes to differentiate between UTI and ASB was evaluated. To investigate the clinical outcomes based on the degree of pyuria, we classified patients with upper UTI according to their urine leukocyte counts.
Results:
Of the 1,793 eligible patients with bacteriuria included, 1,464 had UTI and 329 had ASB. Patients with UTI had higher urinary leukocytes than patients with ASB did (490.4 vs.123.5 cells/µL; P < 0.001). The area under the receiver operating characteristic curve was 0.702 for discriminating between ASB and UTI. The optimal urine leukocyte cutoff was 195.35 cells/µL, with a sensitivity and specificity of 0.70 and 0.60, respectively. A sequential rise in secondary bacteremia rate was observed according to an increase in urine leukocytes in patients with upper UTI, whereas in-hospital mortality showed no corresponding trend.
Conclusion
Urine leukocyte counts could be used to predict UTI occurrence and bacteremia secondary to UTI. Higher degrees of pyuria were associated with bacteremia but not with mortality. Urine leukocyte counts can provide additive information for patients with bacteriuria with vague symptoms.
5.Presenteeism in Agricultural, Forestry and Fishing Workers:Based on the 6th Korean Working Conditions Survey
Sang-Hee HONG ; Eun-Chul JANG ; Soon-Chan KWON ; Hwa-Young LEE ; Myoung-Je SONG ; Jong-Sun KIM ; Mid-Eum MOON ; Sang-Hyeon KIM ; Ji-Suk YUN ; Young-Sun MIN
Journal of Agricultural Medicine & Community Health 2024;49(1):1-12
Objectives:
Presenteeism is known to be a much more economically damaging social cost than disease rest while going to work despite physical pain. Since COVID-19, social discussions on the sickness benefit have been taking place as a countermeasure against presenteeism, and in particular, farmers and fishermen do not have an institutional mechanism for livelihood support when a disease other than work occurs. This study attempted to examine the relationship between agricultural, fishing, and forestry workers and presenteeism using the 6th Korean Work Conditions Survey.
Methods:
From October 2020 to January 2021, data from the 6th working conditions survey conducted on 17 cities and provinces in Korea were used, and a total of 34,981 people were studied. Control variables were gender, age, self-health assessment, education level, night work, shift work, monthly income, occupation, working hours per week, and employment status.
Results:
As a result of the analysis, farmers and fishermen showed the characteristics of the self-employed and the elderly, and as a result of the regression analysis, when farmers and fishermen analyzed the relationship with presenteeism tendency compared to other industry workers, farmers and fishermen increased by 23% compared to other industry groups.
Conclusion
This study is significant in that it has representation by utilizing the 6th working conditions survey and objectively suggests the need for a sickness benefit for farmers and fishermen who may be overlooked in the sickness benefit.
6.Dental Treatment Patterns in Pediatric Patients with Rare Diseases: A Retrospective Analysis at Yonsei University Dental Hospital
Youngseo JOO ; Jaeho LEE ; Hyung-Jun CHOI ; Je Seon SONG ; Ko Eun LEE ; Chung-Min KANG
Journal of Korean Academy of Pediatric Dentistry 2024;51(4):417-431
This study aimed to investigate dental treatment patterns in pediatric patients with rare diseases at Yonsei University Dental Hospital over 3 years. Data of 786 pediatric patients diagnosed with rare diseases who received dental treatment between January 2020 and December 2022 were analyzed retrospectively. Patients were identified through electronic medical record screening for rare disease codes registered with the Korea Disease Control and Prevention Agency. Demographics, rare disease categories, and dental treatment methods and modalities were analyzed using chi-square tests, Fisher’s exact tests, t-tests, and logistic regression. Significant differences in dental treatment needs and methods were observed among categories. Patients with nervous system diseases were less likely to receive preventive or restorative treatments, such as sealants (p = 0.0062) and composite restoration (p = 0.0171), and had a higher prevalence of disabilities (p < 0.00001), leading to greater dental care challenges. Conversely, patients with congenital malformations required more extensive treatments, including stainless-steel crowns (p = 0.0118) and surgery (p = 0.0234), often under general anesthesia (p = 0.0337). The study underscores the importance of tailored dental care protocols and interdisciplinary collaboration to address the needs of pediatric patients with rare diseases, enhancing their oral health outcomes and quality of life.
7.Effects of Dental Sound Insulation System on Stress and Dental Fear Reduction in Pediatric Patients
Sangkyu HAN ; Jaeho LEE ; Eun LEE ; Taeyang LEE ; Wonse PARK ; Je Seon SONG
Journal of Korean Academy of Pediatric Dentistry 2024;51(4):380-391
This study aimed to assess the effectiveness of dental sound insulation in alleviating stress and fear during dental scaling in pediatric patients. It also examined the influence of a noise-canceling application on dentist-patient communication and convenience of dental procedures. This study included 60 children and adolescents aged 7 - 16 years between April 2022 and March 2023. All participants underwent dental plaque control using an ultrasonic scaler on the maxilla first, followed by plaque control on the mandible. Dental sound insulation with active noise canceling was randomly applied to either the maxilla or mandible. Findings revealed that the stress index was significantly reduced when the application was used, with a score of 5.85 compared to 8.43 without it (p < 0.0001). Similarly, the dental fear score was significantly reduced to 1.17 with the application, as opposed to 2.97 without it (p < 0.0001). The dental sound insulation did not affect the communication between dentists and patients or the convenience of treatment. This study demonstrated that active noise canceling during pediatric dental care significantly reduced stress and fear, suggesting that it could be a valuable behavior guidance tool, particularly for children who find dental visits challenging.
8.Presenteeism in Agricultural, Forestry and Fishing Workers:Based on the 6th Korean Working Conditions Survey
Sang-Hee HONG ; Eun-Chul JANG ; Soon-Chan KWON ; Hwa-Young LEE ; Myoung-Je SONG ; Jong-Sun KIM ; Mid-Eum MOON ; Sang-Hyeon KIM ; Ji-Suk YUN ; Young-Sun MIN
Journal of Agricultural Medicine & Community Health 2024;49(1):1-12
Objectives:
Presenteeism is known to be a much more economically damaging social cost than disease rest while going to work despite physical pain. Since COVID-19, social discussions on the sickness benefit have been taking place as a countermeasure against presenteeism, and in particular, farmers and fishermen do not have an institutional mechanism for livelihood support when a disease other than work occurs. This study attempted to examine the relationship between agricultural, fishing, and forestry workers and presenteeism using the 6th Korean Work Conditions Survey.
Methods:
From October 2020 to January 2021, data from the 6th working conditions survey conducted on 17 cities and provinces in Korea were used, and a total of 34,981 people were studied. Control variables were gender, age, self-health assessment, education level, night work, shift work, monthly income, occupation, working hours per week, and employment status.
Results:
As a result of the analysis, farmers and fishermen showed the characteristics of the self-employed and the elderly, and as a result of the regression analysis, when farmers and fishermen analyzed the relationship with presenteeism tendency compared to other industry workers, farmers and fishermen increased by 23% compared to other industry groups.
Conclusion
This study is significant in that it has representation by utilizing the 6th working conditions survey and objectively suggests the need for a sickness benefit for farmers and fishermen who may be overlooked in the sickness benefit.
9.Dental Treatment Patterns in Pediatric Patients with Rare Diseases: A Retrospective Analysis at Yonsei University Dental Hospital
Youngseo JOO ; Jaeho LEE ; Hyung-Jun CHOI ; Je Seon SONG ; Ko Eun LEE ; Chung-Min KANG
Journal of Korean Academy of Pediatric Dentistry 2024;51(4):417-431
This study aimed to investigate dental treatment patterns in pediatric patients with rare diseases at Yonsei University Dental Hospital over 3 years. Data of 786 pediatric patients diagnosed with rare diseases who received dental treatment between January 2020 and December 2022 were analyzed retrospectively. Patients were identified through electronic medical record screening for rare disease codes registered with the Korea Disease Control and Prevention Agency. Demographics, rare disease categories, and dental treatment methods and modalities were analyzed using chi-square tests, Fisher’s exact tests, t-tests, and logistic regression. Significant differences in dental treatment needs and methods were observed among categories. Patients with nervous system diseases were less likely to receive preventive or restorative treatments, such as sealants (p = 0.0062) and composite restoration (p = 0.0171), and had a higher prevalence of disabilities (p < 0.00001), leading to greater dental care challenges. Conversely, patients with congenital malformations required more extensive treatments, including stainless-steel crowns (p = 0.0118) and surgery (p = 0.0234), often under general anesthesia (p = 0.0337). The study underscores the importance of tailored dental care protocols and interdisciplinary collaboration to address the needs of pediatric patients with rare diseases, enhancing their oral health outcomes and quality of life.
10.Effects of Dental Sound Insulation System on Stress and Dental Fear Reduction in Pediatric Patients
Sangkyu HAN ; Jaeho LEE ; Eun LEE ; Taeyang LEE ; Wonse PARK ; Je Seon SONG
Journal of Korean Academy of Pediatric Dentistry 2024;51(4):380-391
This study aimed to assess the effectiveness of dental sound insulation in alleviating stress and fear during dental scaling in pediatric patients. It also examined the influence of a noise-canceling application on dentist-patient communication and convenience of dental procedures. This study included 60 children and adolescents aged 7 - 16 years between April 2022 and March 2023. All participants underwent dental plaque control using an ultrasonic scaler on the maxilla first, followed by plaque control on the mandible. Dental sound insulation with active noise canceling was randomly applied to either the maxilla or mandible. Findings revealed that the stress index was significantly reduced when the application was used, with a score of 5.85 compared to 8.43 without it (p < 0.0001). Similarly, the dental fear score was significantly reduced to 1.17 with the application, as opposed to 2.97 without it (p < 0.0001). The dental sound insulation did not affect the communication between dentists and patients or the convenience of treatment. This study demonstrated that active noise canceling during pediatric dental care significantly reduced stress and fear, suggesting that it could be a valuable behavior guidance tool, particularly for children who find dental visits challenging.

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