1.Parvimonas micra-Induced Paraspinal Abscess and Pyogenic Spondylitis Following Dental Extraction: A Case Report with a Brief Literature Review
Jae Wook YU ; Bu Kwang OH ; Dong Wuk SON ; Jun Seok LEE ; Su Hun LEE ; Soon Ki SUNG ; Sang Weon LEE ; Geun Sung SONG
The Nerve 2024;10(1):39-44
		                        		
		                        			
		                        			 The increasing prevalence of pyogenic spondylitis in older adults is primarily driven by Staphylococcus aureus. Cases caused by anaerobic bacteria are rare. This report focuses on a 71-year-old man diagnosed with spondylitis due to an anaerobic bacterial infection. The causative pathogen—Parvimonas micra—is typically found in the oral cavity. Interestingly, the patient had undergone a tooth extraction before the diagnosis. He was successfully treated with antibiotics; therefore, surgery was not necessary. This case is notable for the uncommon infective organism and, along with a concise literature review, this report provides valuable insights for the medical community.  
		                        		
		                        		
		                        		
		                        	
2.Effect of abatacept versus csDMARDs on rheumatoid arthritis-associated interstitial lung disease
Kyung-Ann LEE ; Bo Young KIM ; Sung Soo KIM ; Yun Hong CHEON ; Sang-Il LEE ; Sang-Hyon KIM ; Jae Hyun JUNG ; Geun-Tae KIM ; Jin-Wuk HUR ; Myeung-Su LEE ; Yun Sung KIM ; Seung-Jae HONG ; Suyeon PARK ; Hyun-Sook KIM
The Korean Journal of Internal Medicine 2024;39(5):855-864
		                        		
		                        			 Background/Aims:
		                        			To compare the effects of abatacept and conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) on the progression and development of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). 
		                        		
		                        			Methods:
		                        			This multi-center retrospective study included RA patients receiving abatacept or csDMARDs who underwent at least two pulmonary function tests and/or chest high-resolution computed tomography (HRCT). We compared the following outcomes between the groups: progression of RA-ILD, development of new ILD in RA patients without ILD at baseline, 28-joint Disease Activity Score with the erythrocyte sedimentation rate (DAS28-ESR), and safety. Longitudinal changes were compared between the groups by using a generalized estimating equation. 
		                        		
		                        			Results:
		                        			The study included 123 patients who were treated with abatacept (n = 59) or csDMARDs (n = 64). Nineteen (32.2%) and 38 (59.4%) patients treated with abatacept and csDMARDs, respectively, presented with RA-ILD at baseline. Newly developed ILD occurred in one patient receiving triple csDMARDs for 32 months. Among patients with RA-ILD at baseline, ILD progressed in 21.1% of cases treated with abatacept and 34.2% of cases treated with csDMARDs during a median 21-month follow-up. Longitudinal changes in forced vital capacity and diffusing capacity for carbon monoxide were comparable between the two groups. However, the abatacept group showed a more significant decrease in DAS28-ESR and glucocorticoid doses than csDMARDs group during the follow-up. The safety of both regimens was comparable. 
		                        		
		                        			Conclusions
		                        			Abatacept and csDMARDs showed comparable effects on the development and stabilization of RA-ILD. Nevertheless, compared to csDMARDs, abatacept demonstrated a significant improvement in disease activity and led to reduced glucocorticoid use. 
		                        		
		                        		
		                        		
		                        	
3.Workload in Emergency Rooms among Clinical Specialties and Overburdened Neurologists
Daeyoung KIM ; Nathan JO ; Jae-Kwan CHA ; Hojin CHOI ; Sang Wuk JEONG ; Im Seok KOH ; Kwang Ik YANG ; Kwang-Yeol PARK ; Kyung-Bok LEE ; Woong-woo LEE ; Dong Hoon SHIN ; Dong Jin SHIN
Journal of the Korean Neurological Association 2022;40(2):127-136
		                        		
		                        			 Background:
		                        			To evaluate workload in emergency rooms (ERs) among clinical specialties including neurology and investigate characteristics of neurological consultations in ER. 
		                        		
		                        			Methods:
		                        			A nationwide survey was conducted to evaluate the number of specialists, resident physicians/surgeons, and emergency consultations of each clinical specialty in Korean tertiary referral hospitals from 2018 to 2019. Characteristics of neurological emergency consultations during the same period were investigated in one of the hospitals that participated. 
		                        		
		                        			Results:
		                        			A total of 23 hospitals were included. Four irrelevant clinical specialties were excluded. The number of neurology specialists and resident physicians were 12.5/hospital (4.1% of all specialists) and 6.4/hospital (3.4% of all resident physicians/surgeons), respectively, while the mean numbers of specialists and resident physicians or surgeons per clinical specialty were 13.7/hospital and 8.6/hospital, respectively. Neurological consultations accounted for 11.0% of all ER consultations for severe patients (Korean Triage and Acuity Scale level 1-3). Annual ER consultations for severe patients per neurology specialist was 274.1, which was only second to pediatrics (290.0). Annual ER consultations for severe patients per resident physician was 406.6 which was 1.6 times higher than the second highest (internal medicine, 247.0). Frequent conditions for neurological ER consultation were dizziness (24.8%), motor weakness (23.9%), headache (10.6%), dysarthria (9.9%), and seizures (7.7%). Frequent primary diagnoses were cerebrovascular diseases (29.0%) and episodic and paroxysmal disorders (24.9%). 
		                        		
		                        			Conclusions
		                        			Workloads of neurology specialists for ER consultation were significantly heavy, and the workload of neurology resident physicians was the heaviest among all specialties. This should be considered in health care policies. 
		                        		
		                        		
		                        		
		                        	
4.The Investigation on the Burden of Neurology Residents to Manage the Patient who Received Thrombolytic Treatment in the Emergency Department with Hyperacute Stroke
Hyun Joon LEE ; Dong Hoon SHIN ; Kwang Ik YANG ; Im-Seok KOH ; Kyung Bok LEE ; Woong-Woo LEE ; Daeyoung KIM ; Kwang-Yeol PARK ; Sang Wuk JEONG ; Hojin CHOI ; Jae-Kwan CHA ; Dong Jin SHIN
Journal of the Korean Neurological Association 2021;39(4):305-311
		                        		
		                        			 Background:
		                        			Because Korea is the fastest aging country, the stroke incidence is increasing rapidly. We investigate the trend of the number of patients with acute stroke in recent years and estimate the burden of the neurologist to treat the acute stroke patient visited the emergency department. 
		                        		
		                        			Methods:
		                        			We requested a questionnaire survey to all teaching hospitals on the number of hospital beds, the number of stroke patients who visited the emergency department, the number of stroke patients in charge of the neurologist, and the number of days on duty of residents from 2016 to 2019. 
		                        		
		                        			Results:
		                        			Of 69 teaching hospitals, 41 hospitals answered the survey. The average hospital beds per hospital were increased annually from 909 to 916. The average patients who visited the emergency department with stroke and were in charged to neurologists were rapidly increased from 799 to 867 per hospital. In particular, the number of patients with hyperacute cerebral infarction requiring the thrombolytic administration or mechanical thrombectomy were rapidly increased from 105 to 131. On the other hand, the average number of residents per hospital was decreased from 5.1 to 4.8. Therefore, the days on duty per resident were increased from 74 to 77. 
		                        		
		                        			Conclusions
		                        			The number of acute stroke patients, especially, hyperacute stroke required the rapid cooperation and high labor were increasing rapidly in recent years. However, because the number of residents were decreased, the burden was increasing. To improve the quality of acute stroke treatment, it is necessary to increase the number of residents. 
		                        		
		                        		
		                        		
		                        	
5.A Recognition Survey by Psychiatry Residents Regarding the Quality of Psychotherapy Training and Psychotherapy Competencies in Korea
Ye Ji KIM ; Yeong Gi KYEON ; Seung Jae LEE ; Myong-Wuk CHON ; Sang Won LEE ; Sung Won JUNG ; Kang Uk LEE ;
Journal of Korean Neuropsychiatric Association 2021;60(3):223-231
		                        		
		                        			Objectives:
		                        			This study surveyed the quality of psychotherapy training and psychotherapy competencies during residency in Korea. 
		                        		
		                        			Methods:
		                        			A questionnaire developed by The Committee of Residency Training of the Korean Neuropsychiatric Association was completed by fourth-year residents of Korean psychiatry (n=120). The questionnaire examined their demographic characteristics, their experience of clinical psychotherapy training, their degree of satisfaction in the quality of psychotherapy training, and self-rated competence regarding the six types of psychotherapies, including supportive psychotherapy, cognitive behavioral therapy, interpersonal psychotherapy, psychoanalytic psychotherapy, group psychotherapy, and family psychotherapy. 
		                        		
		                        			Results:
		                        			The degree of satisfaction of the residents with the psychotherapy training was diverse among the types of psychotherapy and contents of training. Across all types of psychotherapies, the satisfaction levels of the quantity and quality of supervision education were low, except for psychoanalytic psychotherapy. Overall, more than 70% of residents were not satisfied with the theoretical education, clinical practice, and supervision education in three types of psychotherapies, including interpersonal psychotherapy, group psychotherapy, and family psychotherapy. A positive correlation was found between the degree of satisfaction with the quality of training experience and self-rated competence of psychotherapy. Specifically, the self-rated competence of psychotherapy was more highly correlated with the experience of clinical cases and supervision than theoretical education 
		                        		
		                        			Conclusion
		                        			This study showed the quantitative and qualitative status of psychotherapy training in Korean psychiatry residency programs, and the satisfaction level of psychotherapy education was low except for psychoanalytic psychotherapy. There is a strong need for the improvement of psychotherapy training programs in Korea.
		                        		
		                        		
		                        		
		                        	
6.A Recognition Survey by Psychiatry Residents Regarding the Quality of Psychotherapy Training and Psychotherapy Competencies in Korea
Ye Ji KIM ; Yeong Gi KYEON ; Seung Jae LEE ; Myong-Wuk CHON ; Sang Won LEE ; Sung Won JUNG ; Kang Uk LEE ;
Journal of Korean Neuropsychiatric Association 2021;60(3):223-231
		                        		
		                        			Objectives:
		                        			This study surveyed the quality of psychotherapy training and psychotherapy competencies during residency in Korea. 
		                        		
		                        			Methods:
		                        			A questionnaire developed by The Committee of Residency Training of the Korean Neuropsychiatric Association was completed by fourth-year residents of Korean psychiatry (n=120). The questionnaire examined their demographic characteristics, their experience of clinical psychotherapy training, their degree of satisfaction in the quality of psychotherapy training, and self-rated competence regarding the six types of psychotherapies, including supportive psychotherapy, cognitive behavioral therapy, interpersonal psychotherapy, psychoanalytic psychotherapy, group psychotherapy, and family psychotherapy. 
		                        		
		                        			Results:
		                        			The degree of satisfaction of the residents with the psychotherapy training was diverse among the types of psychotherapy and contents of training. Across all types of psychotherapies, the satisfaction levels of the quantity and quality of supervision education were low, except for psychoanalytic psychotherapy. Overall, more than 70% of residents were not satisfied with the theoretical education, clinical practice, and supervision education in three types of psychotherapies, including interpersonal psychotherapy, group psychotherapy, and family psychotherapy. A positive correlation was found between the degree of satisfaction with the quality of training experience and self-rated competence of psychotherapy. Specifically, the self-rated competence of psychotherapy was more highly correlated with the experience of clinical cases and supervision than theoretical education 
		                        		
		                        			Conclusion
		                        			This study showed the quantitative and qualitative status of psychotherapy training in Korean psychiatry residency programs, and the satisfaction level of psychotherapy education was low except for psychoanalytic psychotherapy. There is a strong need for the improvement of psychotherapy training programs in Korea.
		                        		
		                        		
		                        		
		                        	
7.Preoperative Radiological Parameters to Predict Clinical and Radiological Outcomes after Laminoplasty
Su Hun LEE ; Dong Wuk SON ; Jun Jae SHIN ; Yoon HA ; Geun Sung SONG ; Jun Seok LEE ; Sang Weon LEE
Journal of Korean Neurosurgical Society 2021;64(5):677-692
		                        		
		                        			
		                        			Many studies have focused on pre-operative sagittal alignment parameters which could predict poor clinical or radiological outcomes after laminoplasty. However, the influx of too many new factors causes confusion. This study reviewed sagittal alignment parameters, predictive of clinical or radiological outcomes, in the literature. Preoperative kyphotic alignment was initially proposed as a predictor of clinical outcomes. The clinical significance of the K-line and K-line variants also has been studied. Sagittal vertical axis, T1 slope (T1s), T1s-cervical lordosis (CL), anterolisthesis, local kyphosis, the longitudinal distance index, and range of motion were proposed to have relationships with clinical outcomes. The relationship between loss of cervical lordosis (LCL) and T1s has been widely studied, but controversy remains. Extension function, the ratio of CL to T1s (CL/T1s), and Sharma classification were recently proposed as LCL predictors. In predicting postoperative kyphosis, T1s cannot predict postoperative kyphosis, but a low CL/T1s ratio was associated with postoperative kyphosis.
		                        		
		                        		
		                        		
		                        	
8.Preoperative Radiological Parameters to Predict Clinical and Radiological Outcomes after Laminoplasty
Su Hun LEE ; Dong Wuk SON ; Jun Jae SHIN ; Yoon HA ; Geun Sung SONG ; Jun Seok LEE ; Sang Weon LEE
Journal of Korean Neurosurgical Society 2021;64(5):677-692
		                        		
		                        			
		                        			Many studies have focused on pre-operative sagittal alignment parameters which could predict poor clinical or radiological outcomes after laminoplasty. However, the influx of too many new factors causes confusion. This study reviewed sagittal alignment parameters, predictive of clinical or radiological outcomes, in the literature. Preoperative kyphotic alignment was initially proposed as a predictor of clinical outcomes. The clinical significance of the K-line and K-line variants also has been studied. Sagittal vertical axis, T1 slope (T1s), T1s-cervical lordosis (CL), anterolisthesis, local kyphosis, the longitudinal distance index, and range of motion were proposed to have relationships with clinical outcomes. The relationship between loss of cervical lordosis (LCL) and T1s has been widely studied, but controversy remains. Extension function, the ratio of CL to T1s (CL/T1s), and Sharma classification were recently proposed as LCL predictors. In predicting postoperative kyphosis, T1s cannot predict postoperative kyphosis, but a low CL/T1s ratio was associated with postoperative kyphosis.
		                        		
		                        		
		                        		
		                        	
9.Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
Kichul SHIN ; Sung Soo KIM ; Sang-Heon LEE ; Seung-Jae HONG ; Sung Jae CHOI ; Jung-Yoon CHOE ; Seung-Geun LEE ; Hoon-Suk CHA ; Eun Young LEE ; Sung-Hwan PARK ; Jin-Wuk HUR ; Sung Soo NA ; Chang-Hee SUH ; Min Wook SO ; Seung Won CHOI ; Dong-Hyuk SHEEN ; Won PARK ; Shin-Seok LEE ; Wan Hee RYU ; Jin Seok KIM ; Jung Soo SONG ; Hye Soon LEE ; Seong Ho KIM ; Dae-Hyun YOO
The Korean Journal of Internal Medicine 2020;35(1):231-239
		                        		
		                        			
		                        			 The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods: This was a nationwide multicenter observational study. Patients who had three or more active joint counts and abnormal inf lammatory marker in blood test were enrolled. The selection of DMARDs was determined by the attending rheumatologist. Clinical parameters, laboratory findings, and Health Assessment Questionnaire (HAQ) scores were obtained at baseline and at 6 and 12 months. Serial SDAI changes and clinical remission rate at 6 and 12 months were assessed. Results: A total of 850 patients participated in this study. The mean baseline SDAI score in bDMARD group was higher than that in cDMARD group (32.08 ± 12.98 vs 25.69 ± 10.97, p < 0.0001). Mean change of SDAI at 12 months was –19.0 in the bDMARD group and –12.6 in the cDMARD group (p < 0.0001). Clinical remission rates at 12 months in bDMARD and cDMARD groups were 15.4% and 14.6%, respectively. Patient global assessment and HAQ at 12 months were also significantly improved in both groups. Multivariate logistic regression showed that baseline HAQ score was the most notable factor associated with remission. Conclusions: There was a significant reduction in SDAI within 12 months after receiving DMARDs in Korean seropositive RA patients irrespective of bDMARD or cDMARD use in real-world practice. Clinical remission was achieved in those with lower baseline HAQ scores. 
		                        		
		                        		
		                        		
		                        	
10.Estimation of Acute Infarct Volume with Reference Maps: A Simple Visual Tool for Decision Making in Thrombectomy Cases
Dong Eog KIM ; Wi Sun RYU ; Dawid SCHELLINGERHOUT ; Han‐Gil JEONG ; Paul KIM ; Sang Wuk JEONG ; Man Seok PARK ; Kang Ho CHOI ; Joon Tae KIM ; Beom Joon KIM ; Moon Ku HAN ; Jun LEE ; Jae Kwan CHA ; Dae Hyun KIM ; Hyun Wook NAH ; Soo Joo LEE ; Jae Guk KIM ; Keun Sik HONG ; Yong Jin CHO ; Hong Kyun PARK ; Byung Chul LEE ; Kyung Ho YU ; Mi Sun OH ; Jong Moo PARK ; Kyusik KANG ; Kyung Bok LEE ; Tai Hwan PARK ; Sang Soon PARK ; Yong Seok LEE ; Hee Joon BAE
Journal of Stroke 2019;21(1):69-77
		                        		
		                        			
		                        			BACKGROUND AND PURPOSE: Thrombectomy within 24 hours can improve outcomes in selected patients with a clinical-infarct mismatch. We devised an easy-to-use visual estimation tool that allows infarct volume estimation in centers with limited resources. METHODS: We identified 1,031 patients with cardioembolic or large-artery atherosclerosis infarction on diffusion-weighted images (DWIs) obtained before recanalization therapy and within 24 hours of onset, and occlusion of the internal carotid or middle cerebral artery. Acute DWIs were mapped onto a standard template and used to create visual reference maps with known lesion volumes, which were then used in a validation study (with 130 cases) against software estimates of infarct volume. RESULTS: The DWI reference map chart comprises 144 maps corresponding to 12 different infarct volumes (0.5, 1, 2, 3, 5, 7, 9, 11, 13, 15, 17, and 19 mL) in each of 12 template slices (Montreal Neurological Institute z-axis –15 to 51 mm). Infarct volume in a patient is estimated by selecting a slice with a similar infarct size at the corresponding z-axis level on the reference maps and then adding up over all slices. The method yielded good correlations to software volumetrics and was easily learned by both experienced and junior physicians, with approximately 1 to 2 minutes spent per case. The sensitivity, specificity, and accuracy for detecting threshold infarct volumes ( < 21, < 31, and < 51 mL) were very high (all about >90%). CONCLUSIONS: We developed easy-to-use reference maps that allow prompt and reliable visual estimation of infarct volumes for triaging patients to thrombectomy in acute stroke.
		                        		
		                        		
		                        		
		                        			Atherosclerosis
		                        			;
		                        		
		                        			Cerebral Infarction
		                        			;
		                        		
		                        			Decision Making
		                        			;
		                        		
		                        			Diffusion Magnetic Resonance Imaging
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Infarction
		                        			;
		                        		
		                        			Medical Staff, Hospital
		                        			;
		                        		
		                        			Methods
		                        			;
		                        		
		                        			Middle Cerebral Artery
		                        			;
		                        		
		                        			Sensitivity and Specificity
		                        			;
		                        		
		                        			Stroke
		                        			;
		                        		
		                        			Thrombectomy
		                        			
		                        		
		                        	
            
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