Although the proportion of edentulous patients is declining, the aging population has resulted in an increase in their absolute numbers. Conventional complete dentures can partially restore oral function but have significant limitations such as low retention and relatively poor masticatory ability. Therefore, implant overdentures have been proposed as an alternative, offering enhanced functionality, higher patient satisfaction, and cost-effectiveness compared to fixed implants. In this case, a 74-year-old female patient presented with complaints about her existing implant overdenture, fabricated in 2010, which frequently dislodged and was aesthetically unpleasing. Clinical examination revealed worn attachments and artificial teeth, as well as insufficient upper lip support. It was decided to remake the implant overdentures utilizing the existing implants. During the fabrication, the patient continued to use her previous denture. After evaluating the occlusal relationships, facial form, and vertical dimension, the new overdentures were fabricated. The newly created implant overdentures showed satisfactory aesthetic and functional results, and the patient was satisfied.

Although the proportion of edentulous patients is declining, the aging population has resulted in an increase in their absolute numbers. Conventional complete dentures can partially restore oral function but have significant limitations such as low retention and relatively poor masticatory ability. Therefore, implant overdentures have been proposed as an alternative, offering enhanced functionality, higher patient satisfaction, and cost-effectiveness compared to fixed implants. In this case, a 74-year-old female patient presented with complaints about her existing implant overdenture, fabricated in 2010, which frequently dislodged and was aesthetically unpleasing. Clinical examination revealed worn attachments and artificial teeth, as well as insufficient upper lip support. It was decided to remake the implant overdentures utilizing the existing implants. During the fabrication, the patient continued to use her previous denture. After evaluating the occlusal relationships, facial form, and vertical dimension, the new overdentures were fabricated. The newly created implant overdentures showed satisfactory aesthetic and functional results, and the patient was satisfied.

Although the proportion of edentulous patients is declining, the aging population has resulted in an increase in their absolute numbers. Conventional complete dentures can partially restore oral function but have significant limitations such as low retention and relatively poor masticatory ability. Therefore, implant overdentures have been proposed as an alternative, offering enhanced functionality, higher patient satisfaction, and cost-effectiveness compared to fixed implants. In this case, a 74-year-old female patient presented with complaints about her existing implant overdenture, fabricated in 2010, which frequently dislodged and was aesthetically unpleasing. Clinical examination revealed worn attachments and artificial teeth, as well as insufficient upper lip support. It was decided to remake the implant overdentures utilizing the existing implants. During the fabrication, the patient continued to use her previous denture. After evaluating the occlusal relationships, facial form, and vertical dimension, the new overdentures were fabricated. The newly created implant overdentures showed satisfactory aesthetic and functional results, and the patient was satisfied.

Although the proportion of edentulous patients is declining, the aging population has resulted in an increase in their absolute numbers. Conventional complete dentures can partially restore oral function but have significant limitations such as low retention and relatively poor masticatory ability. Therefore, implant overdentures have been proposed as an alternative, offering enhanced functionality, higher patient satisfaction, and cost-effectiveness compared to fixed implants. In this case, a 74-year-old female patient presented with complaints about her existing implant overdenture, fabricated in 2010, which frequently dislodged and was aesthetically unpleasing. Clinical examination revealed worn attachments and artificial teeth, as well as insufficient upper lip support. It was decided to remake the implant overdentures utilizing the existing implants. During the fabrication, the patient continued to use her previous denture. After evaluating the occlusal relationships, facial form, and vertical dimension, the new overdentures were fabricated. The newly created implant overdentures showed satisfactory aesthetic and functional results, and the patient was satisfied.

Although the proportion of edentulous patients is declining, the aging population has resulted in an increase in their absolute numbers. Conventional complete dentures can partially restore oral function but have significant limitations such as low retention and relatively poor masticatory ability. Therefore, implant overdentures have been proposed as an alternative, offering enhanced functionality, higher patient satisfaction, and cost-effectiveness compared to fixed implants. In this case, a 74-year-old female patient presented with complaints about her existing implant overdenture, fabricated in 2010, which frequently dislodged and was aesthetically unpleasing. Clinical examination revealed worn attachments and artificial teeth, as well as insufficient upper lip support. It was decided to remake the implant overdentures utilizing the existing implants. During the fabrication, the patient continued to use her previous denture. After evaluating the occlusal relationships, facial form, and vertical dimension, the new overdentures were fabricated. The newly created implant overdentures showed satisfactory aesthetic and functional results, and the patient was satisfied.

Purpose: This study compared the outcomes of intra-articular fracture reduction for distal radius fractures. Methods: Among 180 patients who underwent open reduction and plate fixation, the exclusion criteria were as follows: non-acute fracture (>1 month), an accompanying ulnar neck fracture, a distal ulnar fracture requiring fixation, fixation through the dorsal approach, other accompanying hand fractures, the absence of preoperative or postoperative computed tomography (CT), and follow-up for <1 year. Intra-articular fractures were evaluated through CT. Forty-eight patients with intra-articular fractures were studied. Displaced intra-articular fractures were defined as: (1) articular step-off ≥1 mm, (2) fracture gap ≥2 mm, or (3) gross incongruence. Reduction was classified as good (n=23) or poor (n=25) based on postoperative CT. The pain visual analogue scale (pVAS), the quick Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, and range of motion of the wrist joint were compared between both groups. Results: No significant between-group differences were found in the preoperative demographic data and the postoperative pVAS and quick DASH scores (pVAS: 0.6 vs. 0.8 and quick DASH: 9.4 vs. 10.2 in the good vs. poor reduction groups, respectively). However, the flexion-extension arc was significantly restricted in the poor reduction group (162° in the good reduction group vs. 146° in the poor reduction group, p<0.001). Conclusion The reduction of the articular surface was not related to pain and functional results at the mid-term follow-up after the surgical treatment of intra-articular distal radius fractures. However, insufficient fracture reduction affected the postoperative range of motion.

Cardio-oncology is a critical field due to the escalating significance of cardiovascular toxicity as a side effect of anti‑ cancer treatments. Cancer therapy-related cardiac dysfunction (CTRCD) is a prevalent condition associated with car‑ diovascular toxicity, necessitating effective strategies for prediction, monitoring, management, and tracking. This comprehensive review examines the definition and risk stratification of CTRCD, explores monitoring approaches during anticancer therapy, and highlights specific cardiovascular toxicities linked to various cancer treatments. These include anthracyclines, HER2-targeted agents, vascular endothelial growth factor inhibitors, immune checkpoint inhibitors, chimeric antigen receptor T-cell therapies, and tumor-infiltrating lymphocytes therapies. Incorporating the Korean data, this review offers insights into the regional nuances in managing CTRCD. Using systematic follow-up incorporating cardiovascular imaging and biomarkers, a better understanding and management of CTRCD can be achieved, optimizing the cardiovascular health of both cancer patients and survivors.

Purpose: This phase II, open-label, multicenter study aimed to investigate the efficacy and safety of a rituximab intensification for the 1st cycle with every 21-day of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP-21) among patients with previously untreated advanced-stage or bulky diffuse large B-cell lymphoma (DLBCL). Materials and Methods: Ninety-two patients with stage III/IV or bulky DLBCL from 21 institutions were administered 8 cycles of R-CHOP-21 with an additional one dose of rituximab intensification on day 0 of the 1st cycle (RR-CHOP). The primary endpoint was a complete response (CR) rate after 3 cycles of chemotherapy. Results: Among the 92 DLBCL patients assessed herein, the response rate after 3 cycles of chemotherapy was 88.0% (38.0% CR+50.0% partial response [PR]). After the completion of 8 cycles of chemotherapy, the overall response rate was observed for 68.4% (58.7% CR+9.8% PR). The 3-year progression-free survival rate was 64.0%, and the 3-year overall survival rate was 70.4%. Febrile neutropenia was one of the most frequent grade 3 adverse events (40.0%) and 5 treatment-related deaths occurred. Compared with the clinical outcomes of patients who received R-CHOP chemotherapy as a historical control, the interim CR rate was higher in male patients with RR-CHOP (20.5% vs. 48.8%, p=0.016). Conclusion Rituximab intensification on days 0 to the 1st cycle of the standard 8 cycles R-CHOP-21 for advanced DLBCL yielded favorable response rates after the 3 cycles of chemotherapy and acceptable toxicities, especially for male patients. ClinicalTrials.gov ID: NCT01054781.

Background/Aims: Fexuprazan is a novel potassium-competitive acid blocker that could be of benefit to patients with gastric mucosal injury. The aim of this study was to assess the 2-week efficacy and safety of fexuprazan in patients with acute or chronic gastritis. Methods: In this study, 327 patients with acute or chronic gastritis who had one or more gastric erosions on endoscopy and subjective symptoms were randomized into three groups receiving fexuprazan 20 mg once a day (q.d.), fexuprazan 10 mg twice a day (b.i.d.), or placebo for 2 weeks. The posttreatment assessments were the primary endpoint (erosion improvement rate), secondary endpoints (cure rates of erosion and edema and improvement rates of redness, hemorrhage, and subjective symptoms), and drug-related adverse events. Results: Among the patients, 57.8% (59/102), 65.7% (67/102), and 40.6% (39/96) showed erosion improvement 2 weeks after receiving fexuprazan 20 mg q.d., fexuprazan 10 mg b.i.d., and placebo, respectively. Both fexuprazan 20 mg q.d. and 10 mg b.i.d. showed superior efficacy to the placebo (p=0.017 and p<0.001, respectively). Likewise, both fexuprazan 20 mg q.d. and 10 mg b.i.d. also showed higher erosion healing rates than the placebo (p=0.033 and p=0.010, respectively). No difference was noted in the edema healing rate and the improvement rates for redness, hemorrhage, and subjective symptoms between the fexuprazan and placebo groups.No significant difference was noted in the incidence of adverse drug reactions. Conclusions Fexuprazan 20 mg q.d. and 10 mg b.i.d. for 2 weeks showed therapeutic efficacy superior to that of placebo in patients with acute or chronic gastritis (ClinicalTrials.gov identifier NCT04341454).

PURPOSE: . The aim of this study was to evaluate the reliability of implant stability measuring devices depending on the location of the implant and the position of the patient. MATERIALS AND METHODS: . Six implants were installed in different dentate sextants of six artificial bone models. Implant stability was measured in three conditions of the bone model (without mounting on a phantom head, mounted on a phantom head in supine position, and mounted on a phantom head in upright position). A resonance frequency analysis device (Osstell) and two damping capacity analysis devices (Periotest and Anycheck) were used to measure implant stability. The values measured outside the phantom head were treated as controls, and the values inside the phantom head were compared using an independent t-test. RESULTS: . Osstell showed different results in two of the six divisions in both the supine and upright positions compared to outside of the mouth (P < .05). Periotest showed different results in all six parts in the supine position and in five parts in the upright position compared to outside of the mouth (P < .05). While Anycheck showed different results in five areas in the supine position compared to outside of the mouth, it showed different results in only one area in the upright position (P < .05). CONCLUSION . In the difficult implant position for the operator to access, the implant stability measuring devices show less reliability. The accessibility of implant is greatly affected in the order of Osstell, Anycheck, and Periotest. [J Adv Prosthodont 2023;15:126-35]