Purpose: : Health literacy, or the ability to find, understand, and use health information, is a key focus in South Korea’s ‘5th National Health Promotion Comprehensive Plan.’ However, despite South Korea’s high internet penetration, research on digital health information use among people with developmental disabilities is limited. This study assesses the current state of digital health literacy in this population. Methods: : A survey was conducted on the people with disabilities and people without disabilities. General digital health information was measured using an 8-item scale by Skinner (2006), and COVID-19-related health information was assessed with a 10-item tool developed by the research team. A total of 365 responses were analyzed, comprising people with physical disabilities (189), developmental disabilities (82), and those without disabilities (94). Data analysis was performed using SPSS version 28, including MANOVA and descriptive statistics. Results: : eHealth scores for individuals with developmental disabilities (24.6 ± 9.8) were significantly lower than those with physical disabilities (32.6 ± 7.9) and those without disabilities (33.9 ± 9.1). Similarly, Covid-eHealth scores were lower for individuals with developmental disabilities (24.6 ± 8.4) compared to those with physical disabilities (29.5 ± 6.8) and those without disabilities (31.3 ± 7.7). The differences in both cases were statistically significant (p < 0.001). Conclusion : This study represents the first comprehensive examination of digital health literacy among people with developmental disabilities in South Korea. The findings indicate that while this group has lower digital health literacy, appropriate education and support can improve their skills. This underscores the need for policies and support systems to ensure they can access and effectively use digital health information, especially as healthcare becomes more digital.

Purpose: : Health literacy, or the ability to find, understand, and use health information, is a key focus in South Korea’s ‘5th National Health Promotion Comprehensive Plan.’ However, despite South Korea’s high internet penetration, research on digital health information use among people with developmental disabilities is limited. This study assesses the current state of digital health literacy in this population. Methods: : A survey was conducted on the people with disabilities and people without disabilities. General digital health information was measured using an 8-item scale by Skinner (2006), and COVID-19-related health information was assessed with a 10-item tool developed by the research team. A total of 365 responses were analyzed, comprising people with physical disabilities (189), developmental disabilities (82), and those without disabilities (94). Data analysis was performed using SPSS version 28, including MANOVA and descriptive statistics. Results: : eHealth scores for individuals with developmental disabilities (24.6 ± 9.8) were significantly lower than those with physical disabilities (32.6 ± 7.9) and those without disabilities (33.9 ± 9.1). Similarly, Covid-eHealth scores were lower for individuals with developmental disabilities (24.6 ± 8.4) compared to those with physical disabilities (29.5 ± 6.8) and those without disabilities (31.3 ± 7.7). The differences in both cases were statistically significant (p < 0.001). Conclusion : This study represents the first comprehensive examination of digital health literacy among people with developmental disabilities in South Korea. The findings indicate that while this group has lower digital health literacy, appropriate education and support can improve their skills. This underscores the need for policies and support systems to ensure they can access and effectively use digital health information, especially as healthcare becomes more digital.

Purpose: : Health literacy, or the ability to find, understand, and use health information, is a key focus in South Korea’s ‘5th National Health Promotion Comprehensive Plan.’ However, despite South Korea’s high internet penetration, research on digital health information use among people with developmental disabilities is limited. This study assesses the current state of digital health literacy in this population. Methods: : A survey was conducted on the people with disabilities and people without disabilities. General digital health information was measured using an 8-item scale by Skinner (2006), and COVID-19-related health information was assessed with a 10-item tool developed by the research team. A total of 365 responses were analyzed, comprising people with physical disabilities (189), developmental disabilities (82), and those without disabilities (94). Data analysis was performed using SPSS version 28, including MANOVA and descriptive statistics. Results: : eHealth scores for individuals with developmental disabilities (24.6 ± 9.8) were significantly lower than those with physical disabilities (32.6 ± 7.9) and those without disabilities (33.9 ± 9.1). Similarly, Covid-eHealth scores were lower for individuals with developmental disabilities (24.6 ± 8.4) compared to those with physical disabilities (29.5 ± 6.8) and those without disabilities (31.3 ± 7.7). The differences in both cases were statistically significant (p < 0.001). Conclusion : This study represents the first comprehensive examination of digital health literacy among people with developmental disabilities in South Korea. The findings indicate that while this group has lower digital health literacy, appropriate education and support can improve their skills. This underscores the need for policies and support systems to ensure they can access and effectively use digital health information, especially as healthcare becomes more digital.

Objective: The purpose of this study was to investigate the accuracy of one-step automated orthodontic diagnosis of skeletodental discrepancies using a convolutional neural network (CNN) and lateral cephalogram images with different qualities from nationwide multi-hospitals. Methods: Among 2,174 lateral cephalograms, 1,993 cephalograms from two hospitals were used for training and internal test sets and 181 cephalograms from eight other hospitals were used for an external test set. They were divided into three classification groups according to anteroposterior skeletal discrepancies (Class I, II, and III), vertical skeletal discrepancies (normodivergent, hypodivergent, and hyperdivergent patterns), and vertical dental discrepancies (normal overbite, deep bite, and open bite) as a gold standard. Pre-trained DenseNet-169 was used as a CNN classifier model. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis, t-stochastic neighbor embedding (t-SNE), and gradientweighted class activation mapping (Grad-CAM). Results: In the ROC analysis, the mean area under the curve and the mean accuracy of all classifications were high with both internal and external test sets (all, > 0.89 and > 0.80). In the t-SNE analysis, our model succeeded in creating good separation between three classification groups. Grad-CAM figures showed differences in the location and size of the focus areas between three classification groups in each diagnosis. Conclusions Since the accuracy of our model was validated with both internal and external test sets, it shows the possible usefulness of a one-step automated orthodontic diagnosis tool using a CNN model. However, it still needs technical improvement in terms of classifying vertical dental discrepancies.

Various vaccines have been developed to fight severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 pandemic.However, new variants of SARS-CoV-2 undermine the effort to fight SARS-CoV-2. Here, we produced S proteins harboring the receptor-binding domain (RBD) of the Omicron variant in plants. Plant-produced S proteins together with adjuvant CIA09A triggered strong immune responses in mice. Antibodies in serum inhibited interaction of recombinant human angiotensinconverting enzyme 2 with RBD of the Omicron variant, but not RBD of other variants. These results suggest that antibodies induced by RBD of the Omicron variant are highly specific for the Omicron RBD, but not for that of other variants.

Through this meta-analysis, we sought to examine the prevalence of, risks for, and factors associated with bullying involvement (victimization, perpetration, perpetration-victimization) among students with autism spectrum disorder (ASD). Additionally, we attempted to examine sources of variance in the prevalence and effect sizes of bullying in students with ASD across studies. Systematic database and literature review identified 34 relevant studies (31 for Western countries, three for Eastern countries). Pooled prevalence estimates for victimization, perpetration, and perpetration-victimization in general were 67%, 29%, and 14%, respectively.The risk of victimization in students with ASD was significantly higher than that in typically developing students and students with other disabilities. Further, deficits in social interaction and communication, externalizing symptoms, internalizing symptoms, and integrated inclusive school settings were related to higher victimization, and externalizing symptoms were related to higher perpetration. Finally, moderation analyses revealed significant variations in the pooled prevalences thereof depending on culture, age, school settings, and methodological quality and in the pooled effect sizes according to publication year and methodological quality. Our results highlight needs for bullying intervention for students with ASD, especially those who are younger, are in an inclusive school setting, and have higher social difficulties and externalizing/internalizing symptoms; for intensive research of bullying experiences among students with ASD in Eastern countries; and for efforts to improve the methodological quality of such research.

Purpose: Since the introduction of nab-paclitaxel plus gemcitabine (nab-P+GEM) as first-line (1L) treatment for metastatic pancreatic adenocarcinoma (mPDAC), optimal second-line (2L) chemotherapy after progression is unclear. We assessed clinical outcomes of 2L chemotherapy for disease that progressed on 1L nab-P+GEM. Materials and Methods: Among the 203 patients previously treated with 1L nab-P+GEM for mPDAC at Asan Medical Center, between February and December 2016, records of 120 patients receiving 2L chemotherapy after progression on nab-P+GEM were retrospectively reviewed. The response rate and survival were evaluated along with analysis of prognostic factors. Results: Fluoropyrimidine-oxaliplatin doublets (FOLFOX or XELOX) were used in 78 patients (65.0%), fluoropyrimidine monotherapy in 37 (30.8%), and liposomal irinotecan plus fluorouracil in two (1.7%). The median progression-free survival (PFS) and overall survival (OS) were 3.29 months and 7.33 months from the start of 2L therapy. Fluoropyrimidine-oxaliplatin regimens and fluoropyrimidine monotherapy did not yield significantly different median PFS (2.89 months vs. 3.81 months, p=0.40) or OS (7.04 months vs. 7.43 months, p=0.86). A high neutrophil-lymphocyte ratio (> 2.2) and a short time to progression with 1L nab-P+GEM (< 6.4 months) were independent prognostic factors of poor OS with 2L therapy. Conclusion 2L fluoropyrimidine-oxaliplatin doublets and fluoropyrimidine monotherapy after failure of 1L nab-P+GEM had modest efficacy, with no differences in treatment outcomes between them. Further investigation is warranted for the optimal 2L chemo-regimens and sequencing of systemic chemotherapy for patients with mPDAC.

No abstract available.
Cerebral Infarction ; Endocarditis* ; Hypereosinophilic Syndrome ; Infarction*

PURPOSE: To evaluate the clinical results of Acutrak screw fixation for ulnar olecranon fractures. MATERIALS AND METHODS: We reviewed 15 cases of ulnar olecranon fractures which were treated with Acutrak screws from February 2003 to September 2007. Follow-up period is from 12 months to 42 months. We used Mayo classification. Radiologic results were analyzed according to step-off, gap, reduction loss, and functional results were analyzed according to pain and ROM. We analyzed union time, operation time, incision size and complications. RESULTS: In functional results, there were 3 good cases out of 3 Mayo type IA, 8 good cases and 2 fair cases out of 10 type IIA, 1 fair case and 1 poor case out of 2 type IIB. In radiologic results, there was 1 case of reduction loss. Average union time was 9.4 weeks, average operation time was 24 minutes and average incision size was 1.8 cm. CONCLUSION: We conclude that Acutrak screw fixation can be a treatment option for olecranon fracture of Mayo type IA and IIA.
Follow-Up Studies ; Olecranon Process ; Ulna

PURPOSE: To evaluate the contralateral breast dose using a virtual wedge compared with that using a physical wedge and an open beam in a Siemens linear accelerator. MATERIALS AND METHODS: The contralateral breast dose was measured using diodes placed on a humanoid phantom. Diodes were placed at 5.5 cm (position 1), 9.5 cm (position 2), and 14 cm (position 3) along the medial-lateral line from the medial edge of the treatment field. A 6-MV photon beam was used with tangential irradiation technique at 50 and 230 degrees of gantry angle. Asymmetrically collimated 17 x 10 cm field was used. For the first set of experiment, four treatment set-ups were used, which were an open medial beam with a 30-degree wedged lateral beam (physical and virtual wedges, respectively) and a 15-degree wedged medial beam with a 15-degree wedged lateral beam (physical and virtual wedges, respectively). The second set of experiment consists of setting with medial beam without wedge, a 15-degree wedge, and a 60-degree wedge (physical and virtual wedges, respectively). Identical monitor units were delivered. Each set of experiment was repeated for three times. RESULTS: In the first set of experiment, the contralateral breast dose was the highest at the position 1 and decreased in order of the position 2 and 3. The contralateral breast dose was reduced with open beam on the medial side (2.70+/-1.46%) compared to medial beam with a wedge (both physical and virtual) (3.25+/-1.59%). The differences were larger with a physical wedge (0.99+/-0.18%) than a virtual wedge (0.10+/-0.01%) at all positions. The use of a virtual wedge reduced the contralateral breast dose by 0.12% to 1.20% of the prescribed dose compared to a physical wedge with same technique. In the second experiment, the contralateral breast dose decreased in order of the open beam, the virtual wedge, and the physical wedge at the position 1, and it decreased in order of a physical wedge, an open beam, and a virtual wedge at the position 2 and 3. CONCLUSION: The virtual wedge equipped in a Siemens linear accelerator was found to be useful in reducing dose to the contralateral breast. Our additional finding was that the surface dose distribution from the Siemens accelerator was different from a Varian accelerator.
Breast* ; Particle Accelerators