Objective: To investigate the influencing factors of overactive bladder (OAB) in college freshmen and the impacts of OAB on their mental health, quality of life and social interaction. Methods: An epidemiological questionnaire survey was conducted in an anonymous manner on the prevalence of OAB among 5300 freshmen aged 17 to 22 years enrolled in the 2023—2024 academic year in Xinxiang Medical University and Sanquan College of Xinxiang Medical University.The questionnaire included questions on basic information, history of urinary tract infection, constipation, smoking, history of alcohol consumption, history of coffee/strong tea drinking, history of carbonated beverage drinking, redundant prepuce, phimosis, holding urine, chronic insomnia, self-rating anxiety scale (SAS), quality of life score (QoL), and social avoidance and distress scale (SADS).The influencing factors of OAB were analyzed with multivariate logistic regression analysis.The subjects were grouped according to whether they had OAB, and the differences in SAS, QoL and SADS between the OAB group and non-OAB group were compared.The impacts of OAB on the anxiety level, quality of life, and social interaction were analyzed with multiple linear regression analysis. Results: The overall prevalence rate of OAB was 4.9% (244/5018).Multivariate logistic regression analysis showed that the history of urinary tract infection (OR=0.177), constipation (OR=0.636), smoking (OR=0.582), alcohol consumption (OR=0.685), coffee/strong tea drinking (OR=0.387), carbonated beverage drinking (OR=0.631), redundant prepuce (OR=0.673), phimosis (OR=0.311), urine holding (OR=0.593), and chronic insomnia (OR=0.256) were influencing factors for the occurrence of OAB (P＜0.05).The OAB group had higher SAS score [(41.18±6.54) vs. (38.61±6.36)], QoL score [(3.65±1.20) vs. (2.79±0.95)], social avoidance score [(6.25±1.86) vs. (5.86±1.51)], social distress score [(6.27±1.59) vs. (5.97±1.32)], and total SADS score [(12.51±2.35) vs. (11.84±2.01)] than the non-OAB group (P＜0.05).The results of multiple linear regression analysis showed that OAB could independently affect the scores of QoL, SAS, and SADS.The OAB group had higher scores of QoL, SAS, and SADS compared with the non-OAB group (P＜0.001). Conclusion: History of urinary tract infection, constipation, smoking, alcohol consumption, coffee/strong tea drinking, carbonated beverage drinking, redundant prepuce, phimosis, urine holding, and chronic insomnia are influencing factors for the occurrence of OAB in male college students.Moreover, OAB has negative impacts on their mental health, quality of life, and social interaction.

Objective:To analyze the accuracy of lung ultrasound and chest X-ray in the diagnosis of neonatal pulmonary disease.Methods:We prospectively collected newborns that needed chest X-ray examination to diagnose pulmonary disease from twelve neonatal intensive care units across the country between June 2019 and April 2020.Each newborn was examined by lung ultrasound within two hours after chest X-ray examination.All chest X-ray and lung ultrasound images were independently read by a radiologist and a sonographer.When there was a disagreement, a panel of two experienced physicians made a final diagnosis based on the clinical history, chest X-ray and lung ultrasound images.Results:A total of 1 100 newborns were enrolled in our study.The diagnostic agreement between chest X-ray and lung ultrasound(Cohen′s kappa coefficient=0.347) was fair.Lung ultrasound(area under the curve=0.778; 95% CI 0.753-0.803) performed significantly better than chest X-ray(area under the curve=0.513; 95% CI 0.483-0.543) in the diagnosis of transient tachypnea of the newborn( P<0.001). The accuracy of lung ultrasound in diagnosing neonatal respiratory distress syndrome, meconium aspiration syndrome, pneumonia and neonatal pulmonary atelectasis was similar to that of chest X-ray. Conclusion:Lung ultrasound, as a low-cost, simple and radiation-free auxiliary examination method, has a diagnostic accuracy close to or even better than that of chest X-ray, which may replace chest X-ray in the diagnosis of some neonatal lung diseases.It should be noted that both chest X-ray and lung ultrasound can only be used as auxiliary means for the diagnosis of lung diseases, and it is necessary to combine imaging with the clinical history and presentation.

OBJECTIVES: To investigate the level and significance of serum γ-glutamyl transferase-to-platelet ratio (GPR) and monocyte count to high-density lipoprotein ratio (MHR) in patients with essential hypertension (EH) and unstable angina (UA). METHODS: A total of 218 patients with coronary angiography aged ≥60 years, who were admitted to the EH hospital of the Department of Cardiac Medicine, Affiliated Hospital of Chengde Medical College, were selected from September 2018 to September 2019. They were divided into an EH+UA group ( RESULTS: Compared with the control group, patients in the EH+UA group and the EH group had higher body mass index (BMI), tyiglyceride (TG), GPR, and MHR, and lower high-density lipoprotein-cholesterol (HDL-C) (all CONCLUSIONS There is a correlation between GPR, MHR and EH combined with UA pectoris, and the combined detection of the two indicators has adjuvant diagnostic value for elderly EH combined with UA.
Aged ; Angina, Unstable ; Cholesterol, HDL ; Coronary Angiography ; Essential Hypertension ; Humans ; Lipoproteins, HDL ; Monocytes

Objective:To investigate the correlation of the gamma-glutamyl transpeptidase to platelet ratio(GPR)and monocyte count to high-density lipoprotein cholesterol(HDL-C)ratio(MHR)with the severity of coronary artery disease in elderly patients with essential hypertension(EH)combined with unstable angina pectoris(UA).Methods:A total of 218 EH patients aged 60 years and over undergoing coronary arteriography admitted to cardiology department of our hospital were enrolled from September 2018 to September 2019.They were divided into the EH plus UA group(n=113)and the simple EH group(n=105)according to whether UA was combined.In addition, 106 patients with normal coronary angiography who were suspected with coronary heart disease were selected as the healthy group.General data of patients between three groups were compared.Severity of coronary artery disease was evaluated using a Gensini score.The correlation of GPR and MHR with coronary Gensini scores was analyzed in the EH plus UA group.Patients in the EH plus UA group were sub-grouped into the single-, double- and triple-vessel disease groups according to the number of disease branches.Differences in coronary Gensini scores, GPR and MHR were compared among subgroups.A receiver operating characteristic(ROC)curve was used to evaluate the auxiliary diagnostic efficacy of GPR, MHR and the combined GPR and MHR in the EH plus UA group.Results:Compared with the healthy group, both EH plus UA group and EH group showed that the BMI(25.8±3.4 kg/m 2, 25.4±3.6 kg/m 2vs.24.2±2.3 kg/m 2), triglyceride(1.9±1.2, 2.0±1.2 vs.1.5±1.1 mmol/L), and MHR(6.6±1.4, 5.8±1.7 vs.4.9±1.7)were increased, and the HDL-C(1.1±0.2 mmol/L, 1.1±0.3 mmol/L vs.1.3±0.3 mmol/L)were reduced( P<0.05), and only EH plus UA group showed that white blood cells(6.7±1.5×10 9/L vs.6.1±1.8×10 9/L), LDL-C(2.3±0.6 mmol/L vs.2.1±0.6 mmol/L)and GPR(0.3±0.1 vs.0.2±0.1)were higher than in the healthy group( P<0.05). Compared with the EH group, the EH plus UA group showed that the GPR(0.3±0.1 vs.0.2±0.1), and MHR(6.6±1.4 vs.5.8±1.7)were increased( P<0.05). The correlation analysis showed that the levels of GPR and MHR were positively correlated with Gensini scores in the EH plus UA group( r=0.537, 0.333, P<0.05), and the correlation was better along with the increased number of diseased branches( P<0.05). The ROC curve analysis showed that GPR had a high specificity and positive predictive value with the specificity of 68.9% and the area under the ROC curve( AUC)of 0.842, while MHR had a high sensitivity with the sensitivity of 92.9%.The combined detection of GPR and MHR had a higher specificity and positive predictive value with a specificity of 84.0% and the AUC of 0.871. Conclusions:The increase of GPR and MHR can be used as a marker to assist the diagnosis of EH combined with UA, and to assess the severity of coronary artery disease in the elderly.

Objective To explore the perinatal risk factors and clinical characteristics of complications of early term neonates.Methods Data of 5 468 live term newborns and their mothers hospitalized in the Third Affiliated Hospital of Zhengzhou University from January 2013 to December 2013 were analyzed.Background information,morbidity and complications of the mothers were compared among early,full and late term groups (n=l 933,3 013,412,respectively).And background information and incidence of complications were also investigated among neonates of early,full and late term groups (n=2 033,3 023,412,respectively),and neonates born between 37-37+6 (n=695) and 38-38+6 weeks (n=1 338).One-way analysis of variance,LSD-t test,logistic regression analysis,Chi-square or Fisher exact test,Pearson Chi-square test,corrected Chi-square test were used for statistical analysis.Results 1.Comparison among the early,full and late term group showed that higher proportions of elder gravida [21.1％(407/1 933),10.5％(317/3 013),6.8％(28/412),x2=127.690],multipara [43.7％(844/1 933),23.1％(697/3 013),15.0％(62/412),x2=287.765],scarred uterus [27.9％(539/1 933),8.9％(267/3013),1.5％(6/412),x2=396.521],higher incidence of cesarean section [75.2％(1 453/1 933),56.2％(1 693/3 013),54.1％(223/412),x2=196.348],hypertensive disorder complicating pregnancy [9.2％(178/1 933),3.5％(105/3 013),2.9％(12/412),x2=79.915],multiple pregnancy[5.1％(99/1 933),0.3％(9/3 013),0.0％(0/412),x2=147.860],gravidity＞1[63.1％(1 220/1 933),47.3％(1 425/3 013),39.6％(163/412),x2=147.668],premature rupture of fetal membranes[20.6％(398/l 933),14.2％(428/3 013),10.2％(42/412),x2=47.217],abnormal amniotic fluid[17.8％(344/1 933),12.3％(370/3 013),11.2％(46/412),x2=32.777],gestational diabetes mellitus[11.5％(223/1 933),5.9％(178/3 013),5.1％(21/412),x2=56.169],abnormal presentation [9.5％(184/1 933),5.1％(155/3 013),2.9％(12/412),x2=43.511],abnormal placenta [7.6％(146/1 933),3.1％(92/3 013),2.7％(11/412),x2=57.739],hysteromyoma[4.9％(94/1 933),2.3％(68/3 013),0.7％(3/412),x2=35.062] in the early term group than in the full and late term group,respectively (all P＜0.016).Multivariate logistic analysis showed that multiple pregnancy (OR=21.736,95％CI:10.785-43.806),scarred uterus (OR=3.302,95％CI:2.679-4.071) and hypertensive disorder complicating pregnancy(OR=2.658,95％CI:2.040-3.465) were the leading three perinatal risk factors for early term delivery.2.The incidence of the following neonatal conditions were different among early,full and late term infants (all P＜0.05):hyperbilirubinemia [12.5％(255/2 033),3.9％(119/3 023),4.9％(20/412),x2=138.343],infectious diseases [4.3％(88/2 033),2.0％(59/3 023),1.7％(7/412),x2=27.122],asphyxia[3.0％(60/2 033,1.4％(42/3 023),1.0％(4/412),x2=17.795],brain damage [2.3％(46/2 033),0.5％(15/3,023),10.％(4/412)],respiratory distress syndrome [1.1％(23/2 033),0.2％(7/3 023),0.0％(0/412)],feeding problems [2.0％(41/2 033),0.3％(10/3 023),1.0％ (4/412)],surgical diseases[2.0％(41/2 033),0.9％(28/3 023),1.5％(6/412),x2=0.709],intracranial hemorrhage [1.9％(39/2 033),0.9％(26/3 023),0.5％(2/412),x2=13.263],wet lung [0.9％(19/2 033),0.4％(11/3 023),0.5％(2/412)].Incidences of the above complications in the early term infants were all higher than in the full term infants,but when compared with the later term infants,only that of hyperbilirubinemia and infectious diseases was higher (all P＜0.016).Incidence of admission ot NICU [24.5％(170/695) vs 11.5％(153/1 338),x2=57.729],hyperbilirubinemia [19.0％(132/695) vs 9.2％(123/1 338),x2=40.046],infectious diseases[6.2％(43/695) vs 3.4％(45/1 338),x2=8.807],brain damage[4.0％(28/695) vs 1.3％(18/1 338),x2=14.828],and NRDS[2.0％(14/695) vs 0.5％(9/1 338),x2=7.329],feeding problems [3.2％(22/695) vs 1.5％(20/1 338),x2=6.271],intracranial hemorrhage [3.2％(22/695) vs 1.3％(17/1 338),x2=8.684],wet lung [1.7％(12/695) vs 0.5％(7/1 338),x2=7.049] of the early term infants born at 37-37+6 weeks were all higher than those born at 38-38+6 weeks(all P＜0.05).Conclusions Multiple pregnancy,scarred uterus and hypertensive disorder of pregnancy are the three leading perinatal risk factors of early term delivery.The incidence of neonatal complications among early term infants are higher than those among full term infants,and early term infants are more likely to stay in NICU.We should take preventive measures to decrease the rate of early term delivery and improve the follow-up management of early term infants.

Objective To investigate the value of spectral CT-based quantitative analysis in the differential diagnosis of liver cancer and liver abscess.Methods A total of 70 patients with space-occupying lesions in the liver (45 with liver cancer and 25 with liver abscess) underwent spectral CT scans to obtain spectral images in the arterial phase and portal venous phase.The solid constituents of lesions and the iodine and water concentrations in necrotic or cystic parts of lesions,normal hepatic tissue,and abdominal aorta in the arterial phase and portal venous phase were measured,and the normalized iodine concentration (NIC) and lesion-to-normal hepatic tissue ratio (LNR) of iodine concentration were calculated.The two samples t-test and the receiver operating characteristic (ROC) curve analysis were performed for the quantitative indices above.Results The patients with liver cancer had higher NIC and LNR in solid constituents in the arterial phase than those with liver abscess (NIC:0.15±0.06 mg/ml vs 0.14±0.02 mg/ml,P ＞ 0.05;LNR:2.78±0.65 vs 1.45±0.88,P ＜ 0.001).The patients with liver abscess had significantly higher NIC and LNR in solid constituents in the portal venous phase than those with liver cancer (NIC:0.65±0.08 mg/ml vs 0.52±0.08 mg/ml,P ≤ 0.001;LNR:1.22±0.23 vs 0.95±0.15,P ≤ 0.001).There were no significant differences in NIC in the arterial phase or NIC and LNR in the portal venous phase in necrotic or cystic parts of lesions between the patients with liver cancer and liver abscess (P ＞ 0.05).The optimal quantitative value for the differential diagnosis of liver cancer and liver abscess was LNR in arterial phase,and the cut-off value of 1.53 had a sensitivity of 100％ and a specificity of 92％.Conclusion Quantitative iodine concentration analysis in spectral CT imaging has a certain value in the differential diagnosis of liver cancer and liver abscess and can improve the accuracy of diagnosis.

Objective To evaluate the reporting quality of Meta-analyses published on Chinese journals of geriatrics.Methods Papers of Meta-analyses on geriatrics published in nine major Chinese journals of geriatrics before November 21,2013 were retrieved,their basic information were abstracted and evaluated through system assessment and preferred reporting items for systematic reviews and Meta-analyses (PRISMA) statement.Statistical analyses were performed with the SPSS17.0 software.Results Among the 71 internalized papers,1 was from 《Geriatrics & Health Care》,1 from 《Practical Geriatrics》,10 from 《Chinese Journal of Geriatric Care》,45 from 《Chinese Journal of Gerontology》,3 from 《Chinese Journal of Multiple Organ Diseases in the Elderly》,1 from 《Chinese Journal of Geriatric Dentistry》,5 from 《Chinese Journal of Geriatric Heart Brain and Vessel Diseases》,5 from 《Chinese Journal of Geriatrics》.55 papers (77.5％) were published in recent 3 years.The mean overall PRISMA score was(16.75±3.04)ranged from 4 to 24.The main influencing factor for the quality of Meta-analyses was the year of publication (adjusted β=-0.342,P=0.003).Conclusions The quantity and quality of Meta-analyses published on Chinese journals of geriatrics are increased and improved in recent years,but there are still some problems on the writing norms.We should promote PRISMA statement and standardize reporting format to improve the quality of Meta-analyses in the field of geriatric medicine.

Objective To study the audiological characteristics of large vestibular aqueduct syndrome (LVAS)and provide evidence for early diagnosis and prevention.Methods Tympanometry,Otoacoustic emission , auditory brainstem response (ABR),auditory steady-state response(ASSR)were performed on the 49 cases of LVAS which were diagnosed by CT scanning from May,2010 to October,2013.Among them,23 cases(46ears)were examined by pure tone andiometry at the same time.ResuIts Pure tone andiometry showed that 33 ears were mixed hearing loss in the 23 cases(46 ears),the air-bone gap was larger at low frequencies than that of at high frequen-cies,15 ears were senserineural hearing loss with no air-bone gap;96 ears were type A tympanogram.Acoustic re-flex were present in 5 ears ;34 cases (68 ears)of LVAS group were detected with ASNR in 3 -4 ms by the ABR testing,the positive rate was 70.8%.ConcIusion Our study indicates that for confirmed LAVS,if the pure tone andiometry shows significant air-bone gaps at low frequencies with the normal tympanograms,and ASNR is e-voked during the routine ABR testing.

Objective To explore the relationship between adenoid vegetation children with different types of tympanograms and secretory otitis media in children and diagnosis of secretory otitis media .Methods A retrospec-tive study was carried out among 328 cases with adenoid vegetation in children ,including simple adenoid vegetation and associated with chronic tonsillitis and tonsillar hypertrophy ,from August 2010 to May 2012 .The incidence of secretory otitis media and outcomes of tympanometry for the diagnosis were analyzed .Results 104 cases were diag-nosed with secretory otitis media by tympanic membrane puncture or tympanostomy tube in 328 cases with adenoid vegetation (32 .31% );86 cases (147 ears) were finally diagnosed as secretory otitis media among 89 cases (152 ears) with type B tympanogram (147/152 ,96 .63% );16 cases (20 ears) were finally diagnosed secretory otitis media among 33 cases (49 ears) with type C tympanogram (20/49 ,40 .82% );2 cases (2 ears) with type As tympa-nogram were finally diagnosed .Conclusion With or without complaint of hearing loss ,children with adenoid vegeta-tion should be checked by routine tympanometry .Careful physical examinations and electric otoscope or ear endosco-py combined tympanometry can greatly reduce the rate of misdiagnosis of secretory otitis media .

Objective To evaluate left ventricular systolic function by real-time three-dimension speckle tracking imaging (RT3D-STI) in coronary artery diseases (CHD) patients,to determine the clinical value of RT3D-STI in CHD.Methods 34 control subjects and 55 patients with CHD by coronary angiography were involved.Left ventricular global longitudinal strain (GLS),left ventricular global circumferential strain (GCS),left ventricular global radial strain (GRS),left ventricular global area strain (GAS) and left ventricular ejection fraction (LVEF),etc,was acquired by RT3D-STI,respectively.The parameters by RT3D-STI to diagnose CHD were analyzed.Results Compared with control group,GLS,GCS,GRS and GAS were significantly decreased in CHD group (P ＜ 0.05).The area under receiver operating characteristics (AUC) curve of GLS to diagnose CHD was 91.6％.The cutoff value,the sensitivity and Youden index of GLS were-12.5,90.3 ％ and 0.612,respectiuely.The cutoff value,the sensitivity and Youden index of GAS were-23.0,95.8％ and 0.539,respectiuely.GLS,GAS correlated well with LVEF in CHD group (r =-0.860,r =-0.926).Conclusions GLS is the most sensitivity and GAS is the most specificity in the all of strain parameters.RT3D-STI can early show the changes of left ventricular global systolic function in patients with CHD.