Objective:To study the beneficial effect of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on sleep disorder and other non-motor symptoms and their related influencing factors in patients with Parkinson's disease (PD).Methods:Thirty-six PD patients accepted bilateral STN-DBS in our hospital from January 2017 to April 2019 were chosen in our study. Two weeks before STN-DBS and one year after STN-DBS, Unified Parkinson's Disease Rating Scale part III (UPDRS III), Mini-Mental State Examination (MMSE), Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), non-motion complications 30 questions questionnaire (NMS), 39 quality of life questionnaire for Parkinson's disease (PDQ39) and Parkinson's disease sleep rating scale (PDSS) were performed on these patients, and the levodopa equivalent dose (LED) of drugs and LED of levodopa receptor agonist were calculated. The improvement rate of each scale before and after STN-DBS were compared, and the correlations of improvement of sleep symptom with improvement rates of scores of each scale were analyzed.Results:The scores of UPDRS III ( "off"episodes), HAMA, HAMD, NMS, PDQ39 in patients one year after STN-DBS were significantly lower as compared with those before STN-DBS ( P<0.05). The total LED and LED of levodopa receptor agonist in patients one year after STN-DBS were significantly decreased as compared with those before STN-DBS ( P<0.05). The total scores of PDSS and sub-scale scores except for PDSS-6 and PDSS-15 scores one year after STN-DBS were significantly higher as compared with those before STN-DBS ( P<0.05). The improvement rates of PDSS total scores and sub-scale scores had correlations with improvement rates of UPDRSIII, HAMA and PDQ39 scores, and total LED deceased rate. Conclusion:Bilateral STN-DBS can obviously improve the night sleep quality of patients, which is partly benefited from improvement of exercise symptoms and anxiety relief.