Objective To explore the functional changes of the glial lymphatic system in patients with spontaneous intracerebral hemorrhage(sICH)by MR diffusion tensor imaging(DTI).Methods The clinical and imaging data of 32 sICH patients(sICH group)and 31 healthy volunteers(control group)were retrospectively collected,and the diffusivity values of DTI in different direc-tions were collected from all the subjects,the diffusion tensor imaging analysis along the perivascular space(DTI-ALPS)index was calculated,the difference of DTI-ALPS index values between the sICH group and the control group was compared,the changes in the function of the glial lymphatic system in sICH patients were evaluated,and the correlation between DTI-ALPS index and clinical indi-cators in sICH patients was further analyzed.Results The DTI-ALPS index of cerebral hemispheres on the lesions side of sICH group was significantly lower than that on the unaffected side(P＜0.01,t=-5.03),and lower than that on the left side of control group(P＜0.01,t=-9.85)and the right side(P＜0.01,t=-8.80).In addition,vascular endothelial growth factor(VEGF)tes-ting was performed in 8 of the 32 patients,and the levels[(187.40±19.11)pg/mL]were significantly higher than the normal range(0-142.20 pg/mL).Conclusion Through the quantitative analysis of the DTI-ALPS index,the damage to the function of the glial lymphatic system of sICH can be reflected,and perhaps the mechanism of pathophysiological changes in the brain after sICH can be reflected from a new perspective by using MR DTI technology.

Objective:To explore the clinical effects of tuina therapy of Yinyang Ruyin combined with aromatherapy on insomnia and quality of life in patients receiving perichemotherapy for breast cancer.Methods:Totally 199 inpatients with insomnia who received perichemotherapy for breast cancer from June 2018 to December 2019 and met inclusion and exclusion criteria were selected and divided into the control group ( n=48) , the tuina therapy of Yinyang Ruyin group ( n=50) , the aromatherapy group ( n=52) , and the combined treatment group ( n=49) according to the computer-generated random sequence. Patients in the control group received routine care; patients in the tuina therapy of Yinyang Ruyin group received tuina therapy of Yinyang Ruyin on this basis; patients in the aromatherapy group received aromatherapy on this basis; patients in the combined treatment group received both tuina therapy of Yinyang Ruyin and aromatherapy. After 6 cycles of chemotherapy, Pittsburgh Sleep Quality Index (PSQI) , Hamilton Depression Scale (HAMD) , and Functional Assessment of Cancer Therapy: General (FACT-G) were used to evaluate the intervention effects of the four groups. Results:The amelioration rates of insomnia in the 3 and 6 chemotherapy cycles after the intervention of the tuina therapy of Yinyang Ruyin group, the aromatherapy group, and the combined treatment group were higher than that of the control group ( P<0.05) ; the amelioration rates of insomnia in the 3 and 6 chemotherapy cycles after the intervention of the combined treatment group was higher than those of the tuina therapy of control group, Yinyang Ruyin group and the aromatherapy group ( P<0.05) . The repeated measures analysis of variance showed that the main effects of intervention in the PSQI, HAMD, and FACT-G scores of the four groups were statistically different ( P<0.05) ; the time of main effects of PSQI, HAMD, and FACT-G scores was significantly different ( P<0.05) ; there was an interaction between the intervention factors of PSQI, HAMD, and FACT-G scores and the time factor ( P<0.05) . Conclusions:Tuina therapy of Yinyang Ruyin combined with aromatherapy can ameliorate the symptoms of insomnia and depression, thereby improving the quality of life of patients.

Objective To explore the short term effects of five second-generation antipsychotics on the serum pro?lactin levels of first-episode schizophrenia patients. Methods Two hundred fifty first-episode schizophrenia patients were randomly divided into five groups and were then treated with risperidone, olanzapine, paliperidone, quetiapine or ziprasidone, respectively. The serum prolactin were tested at baseline, and every week following initiation of treatment. The positive and negative symptom scale (PANSS) and the treatment emergent symptom scale (TESS) were used to evalu?ate the effect and side effect of treatment. Results Repeated measure ANOVA for serum prolactin showed that the main effects of time, the main effect of group, and the interactive effect of time and group were significant (all P<0.01). At the first week, the serum prolactin level of risperidone group was higher than all the other four groups (P<0.05). At the sec?ond, third, fourth and fifth week, the serum prolactin level of risperidone group and olanzapine group was higher than the other three groups (P<0.05). At the end of the sixth week, the serum prolactin level of risperidone group, olanzapine group and paliperidone group was higher than the quetiapine and ziprasidone groups (P<0.05). But serum prolactin level of risperidone group and olanzapine group was higher than that of paliperidone group (P<0.05). The changes of PANSS before and after treatment were significantly different among groups (P<0.05). However, the incidence of the side effects was not significantly different among groups (P>0.05). Conclusion The level of serum prolactin gradually increases in schizophrenia patients receiving treatment of antipsychotics. The short term effects of different second generation antipsy?chotics on serum prolactin vary differently. Risperidol and olanzapine result in the elevation of serum prolactin level in the early period of treatment.