Cardiotocography (CTG) is a non-invasive and important tool for diagnosing fetal distress during pregnancy. To meet the needs of intelligent fetal heart monitoring based on deep learning, this paper proposes a TWD-MOAL deep active learning algorithm based on the three-way decision (TWD) theory and multi-objective optimization Active Learning (MOAL). During the training process of a convolutional neural network (CNN) classification model, the algorithm incorporates the TWD theory to select high-confidence samples as pseudo-labeled samples in a fine-grained batch processing mode, meanwhile low-confidence samples annotated by obstetrics experts were also considered. The TWD-MOAL algorithm proposed in this paper was validated on a dataset of 16 355 prenatal CTG records collected by our group. Experimental results showed that the algorithm proposed in this paper achieved an accuracy of 80.63% using only 40% of the labeled samples, and in terms of various indicators, it performed better than the existing active learning algorithms under other frameworks. The study has shown that the intelligent fetal heart monitoring model based on TWD-MOAL proposed in this paper is reasonable and feasible. The algorithm significantly reduces the time and cost of labeling by obstetric experts and effectively solves the problem of data imbalance in CTG signal data in clinic, which is of great significance for assisting obstetrician in interpretations CTG signals and realizing intelligence fetal monitoring.
Humans ; Pregnancy ; Female ; Cardiotocography/methods* ; Deep Learning ; Neural Networks, Computer ; Algorithms ; Fetal Monitoring/methods* ; Heart Rate, Fetal ; Fetal Distress/diagnosis* ; Fetal Heart/physiology*

Objective To investigate the mechanism and clinical significance of miR-18a-5p and retinoid acid receptor-related orphan receptor-α(RORA)in the proliferation and progression of colorectal cancer(CRC)cells.Methods The expressions of miR-18a-5p and RORA in CRC cells and tissues were detected via qRT-PCR,FISH,and IHC.Cell proliferation capability was detected through EdU and CFSE assay,cell apoptosis by flow cytometry assay,and cell migration and invasion abilities by cell scratch and Transwell invasion assays,respectively.The targeted regulation of miR-18a-5p on RORA was further verified via dual-luciferase reporter assay,cell function rescue test,RT-PCR,and Western blot assay.Finally,bioinformatics was used to explore the molecular mechanism of miR-18a-5p promoting malignant proliferation,invasion,and progression of CRC via regulating RORA.Results miR-18a-5p exhibited a high expression in CRC tissues and cells(P<0.05)and promoted the proliferation,migration,and invasion of CRC cells(P<0.05).In addition,RORA served as the target gene of miR-18a-5p,and its overexpression effectively reduced the promoting function of miR-18a-5p in the malignant biological phenotype of CRC cells(P<0.05).The expression of RORA in CRC tissues showed a significantly positively correlation with the infiltration of CD8+T cells and the expression of its surface marker protein CD8A.Conclusion The targeted regulation of RORA by miR-18a-5p promotes the proliferation and progression of CRC.The miR-18a-5p/RORA regulatory pathway possibly contributes to the immune microenvironment of CRC,which can be a potential therapeutic target for CRC.

Objective: To understand the current situation of college students emotional regulation and its correlation with perceived social support, so as to provide a reference for improving emotional regulation ability among college students. Methods: From September 15 to October 15, 2022, a total of 15 560 students from 27 colleges and universities in Guangdong, Jiangsu, Shandong, Shanghai, Anhui, Hebei, Yunnan, Shanxi and Gansu were enrolled by stratified random sampling method. The Perceived Social Support Scale (PSSS) and the Emotion Regulation Questionnaire (ERQ) were used to investigate, and multiple stepwise regression was used to explore the relationship between perceived social support and emotion regulation of college students. Results: The scores of emotion regulation, cognitive reappraisal and expression inhibition were 44(40, 50), 24(20, 28) and 20(19, 24) respectively. There were significant differences in the scores of emotion regulation, cognitive reappraisal and expression inhibition by age, grade, household registration, only child status,cost of living, and sleep ( H/Z =77.72, 49.73, -5.10, -9.77, 7.68, 168.27 ; 204.55, 317.32, -5.96, -7.60, 131.20, 968.08; 82.18, 148.04, -2.30, -8.03, 64.82, 188.08, P <0.05). In addition, the multiple stepwise regression found that family support, friend support, and other support in perceived social support all had a positive impact on the emotional regulation state of college students ( β =0.137,0.207,0.090), and family support and friend support had a significant positive effect on expression inhibition( β =0.079,0.053) and cognitive reappraisal( β =0.153,0.296)( P <0.01). Conclusion The perceived social support can directly affect the emotional regulation of college students, and improving the emotional regulation ability has a positive significance to promote the mental health level among college students.

Objective To explore the effect of zirconium oxide porcelain teeth on treating patients with restoration of anterior teeth.Methods A total of 124 patients with restoration of anterior teeth were divided into observation group and control group,62 cases in each group.The control group was treated with nicochrome porcelain teeth,while the observation group was treated with zirconium oxide porcelain teeth.The repair effect,complications and tooth function were compared between two groups.Results In the two groups,A,B and C ratios of repair body shape and the grade B of marginal fitness,grade B of color matching and grade B of gingival coloration showed no significant differences (P ＞ 0.05).In the observation group,the grade A of marginal fitness,grade A of color matching and grade A of gingival coloration were significantly higher than the control group (P ＜ 0.05),while the grade C of marginal fitness,grade C of color matching and grade C of gingival coloration and the total incidence rate of complications were significantly lower than the control group (P ＜ 0.05).Score of teeth function after treatment in the observation group was significantly higher than the control group (P ＜ 0.05).Conclusion Zirconium oxide porcelain teeth can effectively improve the repair effect of the patients with restoration of anterior teeth,reduce the complications and improve the function of the teeth.

Objective To explore the effect of zirconium oxide porcelain teeth on treating patients with restoration of anterior teeth.Methods A total of 124 patients with restoration of anterior teeth were divided into observation group and control group,62 cases in each group.The control group was treated with nicochrome porcelain teeth,while the observation group was treated with zirconium oxide porcelain teeth.The repair effect,complications and tooth function were compared between two groups.Results In the two groups,A,B and C ratios of repair body shape and the grade B of marginal fitness,grade B of color matching and grade B of gingival coloration showed no significant differences (P ＞ 0.05).In the observation group,the grade A of marginal fitness,grade A of color matching and grade A of gingival coloration were significantly higher than the control group (P ＜ 0.05),while the grade C of marginal fitness,grade C of color matching and grade C of gingival coloration and the total incidence rate of complications were significantly lower than the control group (P ＜ 0.05).Score of teeth function after treatment in the observation group was significantly higher than the control group (P ＜ 0.05).Conclusion Zirconium oxide porcelain teeth can effectively improve the repair effect of the patients with restoration of anterior teeth,reduce the complications and improve the function of the teeth.