Hangovers from alcohol consumption cause symptoms like headaches, nausea, and fatigue, disrupting daily activities and overall well-being. Over time, they can also lead to inflammation and oxidative stress. Effective hangover relief alleviates symptoms, prevents dehydration, and replenishes energy needed for daily tasks. Natural foods considered high in antioxidants and antiinflammatory properties may aid in the hepatic breakdown of alcohol. The study aims to investigate the impact of glutathione or its enriched yeast extract, which is recognized for its antioxidant characteristics, on alcohol metabolism and alleviating hangovers in a rat model exposed to binge drinking. In this study, glutathione and its enriched yeast extract controlled hangover behaviour patterns, including locomotor activity. Additionally, it enhanced the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) following ethanol ingestion (3 g/kg). Further, the incorporation of glutathione led to an increase in the expression of antioxidant enzymes, such as SOD and catalase, by activating the nuclear erythroid 2-related factor 2 (Nrf2) signaling pathway.This activation reduced the excessive production of reactive oxygen species (ROS) and malondialdehyde. Next, glutathione modulated the activity of cytochrome P450 2E1 (CYP2E1) and the protein expressions of Bax and Bcl2. Besides, in vitro and in vivo investigations with glutathione demonstrated a regulating effect on the pan-s-glutathionylation and its associated protein expression, glutaredoxin 1 (Grx1), glutathione-S-transferase Pi (GST-π), and glutathione reductase (GR). Together, these findings suggest that glutathione or its enriched yeast extract as a beneficial dietary supplement for alleviating hangover symptoms by enhancing alcohol metabolism and its associated Nrf2/Keap1 signalings.

Hangovers from alcohol consumption cause symptoms like headaches, nausea, and fatigue, disrupting daily activities and overall well-being. Over time, they can also lead to inflammation and oxidative stress. Effective hangover relief alleviates symptoms, prevents dehydration, and replenishes energy needed for daily tasks. Natural foods considered high in antioxidants and antiinflammatory properties may aid in the hepatic breakdown of alcohol. The study aims to investigate the impact of glutathione or its enriched yeast extract, which is recognized for its antioxidant characteristics, on alcohol metabolism and alleviating hangovers in a rat model exposed to binge drinking. In this study, glutathione and its enriched yeast extract controlled hangover behaviour patterns, including locomotor activity. Additionally, it enhanced the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) following ethanol ingestion (3 g/kg). Further, the incorporation of glutathione led to an increase in the expression of antioxidant enzymes, such as SOD and catalase, by activating the nuclear erythroid 2-related factor 2 (Nrf2) signaling pathway.This activation reduced the excessive production of reactive oxygen species (ROS) and malondialdehyde. Next, glutathione modulated the activity of cytochrome P450 2E1 (CYP2E1) and the protein expressions of Bax and Bcl2. Besides, in vitro and in vivo investigations with glutathione demonstrated a regulating effect on the pan-s-glutathionylation and its associated protein expression, glutaredoxin 1 (Grx1), glutathione-S-transferase Pi (GST-π), and glutathione reductase (GR). Together, these findings suggest that glutathione or its enriched yeast extract as a beneficial dietary supplement for alleviating hangover symptoms by enhancing alcohol metabolism and its associated Nrf2/Keap1 signalings.

Hangovers from alcohol consumption cause symptoms like headaches, nausea, and fatigue, disrupting daily activities and overall well-being. Over time, they can also lead to inflammation and oxidative stress. Effective hangover relief alleviates symptoms, prevents dehydration, and replenishes energy needed for daily tasks. Natural foods considered high in antioxidants and antiinflammatory properties may aid in the hepatic breakdown of alcohol. The study aims to investigate the impact of glutathione or its enriched yeast extract, which is recognized for its antioxidant characteristics, on alcohol metabolism and alleviating hangovers in a rat model exposed to binge drinking. In this study, glutathione and its enriched yeast extract controlled hangover behaviour patterns, including locomotor activity. Additionally, it enhanced the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) following ethanol ingestion (3 g/kg). Further, the incorporation of glutathione led to an increase in the expression of antioxidant enzymes, such as SOD and catalase, by activating the nuclear erythroid 2-related factor 2 (Nrf2) signaling pathway.This activation reduced the excessive production of reactive oxygen species (ROS) and malondialdehyde. Next, glutathione modulated the activity of cytochrome P450 2E1 (CYP2E1) and the protein expressions of Bax and Bcl2. Besides, in vitro and in vivo investigations with glutathione demonstrated a regulating effect on the pan-s-glutathionylation and its associated protein expression, glutaredoxin 1 (Grx1), glutathione-S-transferase Pi (GST-π), and glutathione reductase (GR). Together, these findings suggest that glutathione or its enriched yeast extract as a beneficial dietary supplement for alleviating hangover symptoms by enhancing alcohol metabolism and its associated Nrf2/Keap1 signalings.

Objective: This study evaluated the relationship between IVD degeneration and the vertebral body FSF in dogs and compared these factors between chondrodystrophic (CD) and nonchondrodystrophic (NCD) dogs. Methods: IVD degeneration in dogs was classified morphologically using the Pfirrmann grade, and the vertebral body FSF was evaluated quantitatively. Results: The vertebral body FSF showed a statistically significant difference among the age groups. The vertebral body FSF was significantly higher in Pfirrmann grades 3–5 than in grades 1 and 2. The mean Pfirrmann grade of CD dogs was higher than that of NCD dogs in the four-to-six-year-old group. The mean vertebral body FSF of CD dogs was higher than that of NCD dogs in the group of seven years and above. Conclusions and Relevance: In dogs, the vertebral body FSF increased significantly with age and Pfirrmann grade. The CD dogs showed a higher degree of IVD degeneration at a younger age than the NCD dogs. CD dogs appeared to experience more severe fat deposition of the vertebral body in old age than NCD dogs. MRI examinations are helpful for evaluating IVD degeneration and vertebral body fat deposition.

Objective: This study evaluated the relationship between IVD degeneration and the vertebral body FSF in dogs and compared these factors between chondrodystrophic (CD) and nonchondrodystrophic (NCD) dogs. Methods: IVD degeneration in dogs was classified morphologically using the Pfirrmann grade, and the vertebral body FSF was evaluated quantitatively. Results: The vertebral body FSF showed a statistically significant difference among the age groups. The vertebral body FSF was significantly higher in Pfirrmann grades 3–5 than in grades 1 and 2. The mean Pfirrmann grade of CD dogs was higher than that of NCD dogs in the four-to-six-year-old group. The mean vertebral body FSF of CD dogs was higher than that of NCD dogs in the group of seven years and above. Conclusions and Relevance: In dogs, the vertebral body FSF increased significantly with age and Pfirrmann grade. The CD dogs showed a higher degree of IVD degeneration at a younger age than the NCD dogs. CD dogs appeared to experience more severe fat deposition of the vertebral body in old age than NCD dogs. MRI examinations are helpful for evaluating IVD degeneration and vertebral body fat deposition.

Objective: This study evaluated the relationship between IVD degeneration and the vertebral body FSF in dogs and compared these factors between chondrodystrophic (CD) and nonchondrodystrophic (NCD) dogs. Methods: IVD degeneration in dogs was classified morphologically using the Pfirrmann grade, and the vertebral body FSF was evaluated quantitatively. Results: The vertebral body FSF showed a statistically significant difference among the age groups. The vertebral body FSF was significantly higher in Pfirrmann grades 3–5 than in grades 1 and 2. The mean Pfirrmann grade of CD dogs was higher than that of NCD dogs in the four-to-six-year-old group. The mean vertebral body FSF of CD dogs was higher than that of NCD dogs in the group of seven years and above. Conclusions and Relevance: In dogs, the vertebral body FSF increased significantly with age and Pfirrmann grade. The CD dogs showed a higher degree of IVD degeneration at a younger age than the NCD dogs. CD dogs appeared to experience more severe fat deposition of the vertebral body in old age than NCD dogs. MRI examinations are helpful for evaluating IVD degeneration and vertebral body fat deposition.

Objective: This study evaluated the relationship between IVD degeneration and the vertebral body FSF in dogs and compared these factors between chondrodystrophic (CD) and nonchondrodystrophic (NCD) dogs. Methods: IVD degeneration in dogs was classified morphologically using the Pfirrmann grade, and the vertebral body FSF was evaluated quantitatively. Results: The vertebral body FSF showed a statistically significant difference among the age groups. The vertebral body FSF was significantly higher in Pfirrmann grades 3–5 than in grades 1 and 2. The mean Pfirrmann grade of CD dogs was higher than that of NCD dogs in the four-to-six-year-old group. The mean vertebral body FSF of CD dogs was higher than that of NCD dogs in the group of seven years and above. Conclusions and Relevance: In dogs, the vertebral body FSF increased significantly with age and Pfirrmann grade. The CD dogs showed a higher degree of IVD degeneration at a younger age than the NCD dogs. CD dogs appeared to experience more severe fat deposition of the vertebral body in old age than NCD dogs. MRI examinations are helpful for evaluating IVD degeneration and vertebral body fat deposition.

PURPOSE: This study was performed to assess the radiologic and clinical results of U-blade Gamma3 nail use for the treatment of trochanteric fractures. MATERIALS AND METHODS: Between September 2015 and May 2018, all patients aged 65 years and older who underwent surgery with U-blade Gamma3 nails were analyzed. A total of 129 patients were selected based on having at least six months of follow-up. Image evaluations included bone quality (T-score), fracture classification on plain radiograph (AO/OTA), computed tomography configuration, union period, position of lag screw, anatomical reduction, tip apex distance (TAD), sliding extent of lag screw, change of neck shaft angle, and complications leading to reoperations were analyzed. Functional outcome were assessed using the Koval grade (ambulatory ability) at the final follow-up. RESULTS: The mean time to union was 19.7 (range, 6–36) weeks. The screw position was centric (93 cases; 72.1%) and anatomical reduction was achieved in 74 cases (57.4%). The mean TAD was 20.3 (range, 12.3–38.1) mm. The mean sliding length of the lag screws was 3.8 (range, 0.1–12.6) mm. The mean change of neck shaft angle was 3.4° (range, 0–12.8°). Reoperations were required in two cases (1.6%) due to the cutting out of the lag screw (n=1) and metal failure with U-blade bending (n=1). Finally, Koval grades for 49.8% of patients reached preoperative status. CONCLUSION: Overall, use of the U-blade Gamma3 nail led to favorable clinical results, suggesting that this system may be a good option for the treatment of trochanteric fractures.
Classification ; Femur ; Follow-Up Studies ; Hip Fractures ; Humans ; Neck ; Retrospective Studies

Hepatocellular carcinoma (HCC) is the sixth most common cause of death worldwide and the main cause of primary liver cancer. The principle problem of HCC is the poor prognosis, since advanced HCC reportedly has a median survival of only 9 months. The standard therapies are sorafenib and regorafenib, but the outcomes remain unclear. We report a 60-year-old man with advanced HCC with right adrenal gland metastasis and portal vein tumor thrombosis, who showed a complete response to multiple applications of an interdisciplinary therapy.
Adrenal Glands* ; Carcinoma, Hepatocellular* ; Cause of Death ; Follow-Up Studies* ; Humans ; Liver Neoplasms ; Middle Aged ; Neoplasm Metastasis* ; Portal Vein* ; Prognosis ; Thrombosis ; Venous Thrombosis*

No abstract available.
Atherosclerosis* ; Inflammation* ; Lymphoma, B-Cell, Marginal Zone* ; Renal Artery* ; Ureter*