Post-stroke fatigue (PSF) is a common complication after stroke with complex pathogenesis and many influencing factors. It is characterized by fatigue that is not consistent with activity, accompanied by lack of voluntary activity willingness, and usually cannot be improved by rest. PSF seriously affects the prognosis of stroke patients, and early identification and intervention of PSF high-risk groups can help improve the prognosis of PSF patients. This article reviews the pathogenesis, related factors and treatment progress of PSF.