1.Electrocardiogram classification algorithm based on CvT-13 and multimodal image fusion.
Guoquan LI ; Shuangqing ZHU ; Zitong LIU ; Jinzhao LIN ; Yu PANG
Journal of Biomedical Engineering 2023;40(4):736-742
		                        		
		                        			
		                        			Electrocardiogram (ECG) signal is an important basis for the diagnosis of arrhythmia and myocardial infarction. In order to further improve the classification effect of arrhythmia and myocardial infarction, an ECG classification algorithm based on Convolutional vision Transformer (CvT) and multimodal image fusion was proposed. Through Gramian summation angular field (GASF), Gramian difference angular field (GADF) and recurrence plot (RP), the one-dimensional ECG signal was converted into three different modes of two-dimensional images, and fused into a multimodal fusion image containing more features. The CvT-13 model could take into account local and global information when processing the fused image, thus effectively improving the classification performance. On the MIT-BIH arrhythmia dataset and the PTB myocardial infarction dataset, the algorithm achieved a combined accuracy of 99.9% for the classification of five arrhythmias and 99.8% for the classification of myocardial infarction. The experiments show that the high-precision computer-assisted intelligent classification method is superior and can effectively improve the diagnostic efficiency of arrhythmia as well as myocardial infarction and other cardiac diseases.
		                        		
		                        		
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Electrocardiography
		                        			;
		                        		
		                        			Heart Diseases
		                        			;
		                        		
		                        			Myocardial Infarction/diagnostic imaging*
		                        			;
		                        		
		                        			Algorithms
		                        			;
		                        		
		                        			Electric Power Supplies
		                        			
		                        		
		                        	
3.Risk factors of low cardiac output syndrome after cardiac valvular surgery in elderly patients with valvular disease complicated with giant left ventricle.
Zhao LI ; Guo Bao ZHANG ; Ting Wu LI ; Yu ZHANG ; Meng Die LI ; Yue WU
Chinese Journal of Cardiology 2021;49(4):368-373
		                        		
		                        			
		                        			Objective: To explore the risk factors of low cardiac output syndrome (LCOS) after cardiac valvular surgery in elderly patients with valvular disease complicated with giant left ventricle. Methods: This was a retrospective study. The clinical data of patients over 60 years old with giant left ventricle who underwent cardiac valvular surgery in Henan Provincial People's Hospital (Fuwai Central China Cardiovascular Hospital) from January 2016 to January 2020 were collected in this study. Patients were divided into LCOS group and non-LCOS group. The clinical data, preoperative echocardiographic results and surgical data of all patients were collected. Taking LCOS as dependent variable and statistically significant variables in univariate analysis as independent variable, multivariate logistic regression equation was constructed to identify the risk factors of LCOS after cardiac valvular surgery in elderly patients with valvular disease complicated with giant left ventricle. On the basis of logistic regression, the risk factors of continuous variables were put into the regression model for trend test. Results: A total of 112 patients were included, among whom 76 patients were male, the mean age was (65.3±3.8) years. There were 21 cases in LCOS group and 91 cases in non LCOS group. Univariate analysis showed that age≥70 years, preoperative NYHA cardiac function class Ⅳ, preoperative renal dysfunction, preoperative cerebrovascular disease, preoperative LVEF<40%, blood loss/total blood volume>20%, cardiopulmonary bypass (CPB) time>130 minutes and aortic cross-clamp time>90 minutes all had statistically significant differences between the two groups (all P<0.05). Multivariate logistic regression analysis showed that age≥70 years (OR=5.067, 95%CI 1.320-19.456, P=0.018), preoperative NYHA cardiac function class Ⅳ (OR=3.100, 95%CI 1.026-9.368, P=0.045), renal dysfunction (OR=3.627, 95%CI 1.018-12.926, P=0.047), CPB time>130 minutes (OR=4.539, 95%CI 1.483-13.887, P=0.008) were the independent risk factors of LCOS after cardiac valvular surgery in elderly patients with giant left ventricle. Risk of LCOS was significantly higher in patients aged from 65 to 70 years (OR=1.784, 95%CI 0.581-5.476) and aged 70 years and above (OR=4.400, 95%CI 1.171-16.531) than in patients aged from 60 to 65 years. The trend test results showed that the risk of LCOS increased significantly in proportion with the increase of age (P for trend=0.024). Risk of LCOS was significantly higher in patients with CPB time between 90 and 110 minutes (OR=1.917, 95%CI 0.356-10.322), 110 and 130 minutes (OR=1.437, 95%CI 0.114-18.076) and 130 minutes and above (OR=5.750, 95%CI 1.158-28.551) than in patients with CPB time ≤ 90 minutes (P for trend=0.009). Conclusions: The risk factors of LCOS after cardiac valvular surgery are age≥70 years, preoperative NYHA cardiac function class Ⅳ, renal dysfunction, CPB time>130 minutes in elderly patients with giant left ventricle.
		                        		
		                        		
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Cardiac Output, Low/etiology*
		                        			;
		                        		
		                        			China
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Heart Valve Diseases
		                        			;
		                        		
		                        			Heart Ventricles/diagnostic imaging*
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Risk Factors
		                        			
		                        		
		                        	
4.A review on cardiac positron emission tomography/magnetic resonance imaging in diagnosis of cardivascular diseases.
Haotian CHEN ; Rang WANG ; Jing WEI ; Chengzhong FAN
Journal of Biomedical Engineering 2020;37(5):897-902
		                        		
		                        			
		                        			There are various examination methods for cardiovascular diseases. Non-invasive diagnosis and prognostic information acquisition are the current research hotspots of related imaging examinations. Positron emission tomography (PET)/magnetic resonance imaging (MRI) is a new advanced fusion imaging technology that combines the molecular imaging of PET with the soft tissue contrast function of MRI to achieve their complementary advantages. This article briefly introduces several major aspects of cardiac PET/MRI in the diagnosis of cardiovascular disease, including atherosclerosis, ischemic cardiomyopathy, nodular heart disease, and myocardial amyloidosis, in order to promote cardiac PET/MRI to be more widely used in precision medicine in this field.
		                        		
		                        		
		                        		
		                        			Heart/diagnostic imaging*
		                        			;
		                        		
		                        			Heart Diseases/diagnostic imaging*
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Magnetic Resonance Imaging
		                        			;
		                        		
		                        			Multimodal Imaging
		                        			;
		                        		
		                        			Positron-Emission Tomography
		                        			
		                        		
		                        	
6.Prevalence, Presentation, and Outcome of Heart Failure with Preserved Ejection Fraction among Patients Presenting with Undifferentiated Dyspnoea to the Emergency Room: A 10-year Analysis from a Tertiary Centre.
Wen RUAN ; Swee Han LIM ; Zee Pin DING ; David Kl SIM ; Fei GAO ; Kurugulasigamoney GUNASEGARAN ; Bernard Wk KWOK ; Ru San TAN
Annals of the Academy of Medicine, Singapore 2016;45(1):18-26
INTRODUCTIONWe assessed the local prevalence, characteristics and 10-year outcomes in a heart failure (HF) cohort from the emergency room (ER).
MATERIALS AND METHODSPatients presenting with acute dyspnoea to ER were prospectively enrolled from December 2003 to December 2004. HF was diagnosed by physicians' adjudication based on clinical assessment and echocardiogram within 12 hours, blinded to N-terminal-pro brain natriuretic peptide (NT-proBNP) results. They were stratified into heart failure with preserved (HFPEF) and reduced ejection fraction (HFREF) by left ventricular ejection fraction (LVEF).
RESULTSAt different cutoffs of LVEF of ≥50%, ≥45%, ≥40%, and >50% plus excluding LVEF 40% to 50%, HFPEF prevalence ranged from 38% to 51%. Using LVEF ≥50% as the final cutoff point, at baseline, HFPEF (n = 35), compared to HFREF (n = 55), had lower admission NT- proBNP (1502 vs 5953 pg/mL, P <0.001), heart rate (86 ± 22 vs 98 ± 22 bpm, P = 0.014), and diastolic blood pressure (DBP) (75 ± 14 vs 84 ± 20 mmHg, P = 0.024). On echocardiogram, compared to HFREF, HFPEF had more LV concentric remodelling (20% vs 2%, P = 0.003), less eccentric hypertrophy (11% vs 53%, P <0.001) and less mitral regurgitation from functional mitral regurgitation (60% vs 95%, P = 0.027). At 10 years, compared to HFREF, HFPEF had similar primary endpoints of a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and rehospitalisation for congestive heart failure (CHF) (HR 0.886; 95% CI, 0.561 to 1.399; P = 0.605), all-cause mortality (HR 0.663; 95% CI, 0.400 to 1.100; P = 0.112), but lower cardiovascular mortality (HR 0.307; 95% CI, 0.111 to 0.850; P = 0.023).
CONCLUSIONIn the long term, HFPEF had higher non-cardiovascular mortality, but lower cardiovascular mortality compared to HFREF.
Aged ; Aged, 80 and over ; Cardiovascular Diseases ; mortality ; Dyspnea ; diagnosis ; physiopathology ; Echocardiography ; Emergency Service, Hospital ; Female ; Heart Failure ; blood ; diagnostic imaging ; epidemiology ; physiopathology ; Humans ; Hypertrophy, Left Ventricular ; Male ; Middle Aged ; Mitral Valve Insufficiency ; epidemiology ; Myocardial Infarction ; epidemiology ; Natriuretic Peptide, Brain ; blood ; Peptide Fragments ; blood ; Prevalence ; Prospective Studies ; Singapore ; epidemiology ; Stroke ; epidemiology ; Stroke Volume ; Tertiary Care Centers ; Ventricular Remodeling
7.Aortic Dilatation at Different Levels of the Ascending Aorta in Patients with Bicuspid Aortic Valve.
Fei Qiong HUANG ; Kenneth Wq GUO ; Liang ZHONG ; Fei GAO ; Ju Le TAN
Annals of the Academy of Medicine, Singapore 2016;45(6):251-255
INTRODUCTIONBicuspid aortic valve (BAV) is the most common form of adult congenital heart disease. When compared to patients with a normal trileaflet aortic valve, dilatation of the aortic root and the ascending aorta (Asc Ao) are the common findings in patients with BAV, with consequent higher risk of developing aortic aneurysm, aortic dissection and rupture. We aim to determine the site of the Asc Ao where maximum dilatation occurs in Asian adult patients with BAV.
MATERIALS AND METHODSAll subjects underwent full echocardiography examination. The diameter of the Asc Ao was measured at 3 cm, 4 cm, 5 cm, 6 cm and 7 cm from the level of aortic annulus to the Asc Ao in 2D from the parasternal long-axis view.
RESULTSA total of 80 patients (male/female: 45/35; mean age: 45.3 ± 16.2 years) with congenital BAV and 30 normal control group (male/female: 16/14; mean age: 45.9 ± 15.1 years) were enrolled. The indexed diameters of the Asc Ao were significantly larger than the control group. In patients with BAV, maximum dilatation of Asc Ao occurred around 6 cm distal to the aortic annulus.
CONCLUSIONIn patients with BAV, dilatation of Asc Ao is maximal at the mid Asc Ao region around 6 cm distal to the aorta annulus.
Adult ; Aneurysm, Dissecting ; epidemiology ; Aorta ; diagnostic imaging ; Aortic Aneurysm ; epidemiology ; Aortic Diseases ; diagnostic imaging ; epidemiology ; Aortic Rupture ; epidemiology ; Aortic Valve ; abnormalities ; diagnostic imaging ; Case-Control Studies ; Comorbidity ; Dilatation, Pathologic ; diagnostic imaging ; epidemiology ; Echocardiography ; Female ; Heart Valve Diseases ; diagnostic imaging ; epidemiology ; Humans ; Male ; Middle Aged ; Risk Factors ; Singapore ; epidemiology
8.Fever in a Patient with a Previous Gastrectomy.
Debra Gf SEOW ; Po Fun CHAN ; Boon Lock CHIA ; Joshua Py LOH
Annals of the Academy of Medicine, Singapore 2016;45(3):117-120
		                        		
		                        		
		                        		
		                        			Adenocarcinoma
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Candidiasis
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			Cardiac Tamponade
		                        			;
		                        		
		                        			diagnosis
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			Echocardiography
		                        			;
		                        		
		                        			Electrocardiography
		                        			;
		                        		
		                        			Esophageal Fistula
		                        			;
		                        		
		                        			complications
		                        			;
		                        		
		                        			diagnostic imaging
		                        			;
		                        		
		                        			Fever
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			Gastrectomy
		                        			;
		                        		
		                        			Haemophilus Infections
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			Heart Diseases
		                        			;
		                        		
		                        			complications
		                        			;
		                        		
		                        			diagnostic imaging
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Pericardial Effusion
		                        			;
		                        		
		                        			diagnostic imaging
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			Pericarditis
		                        			;
		                        		
		                        			diagnostic imaging
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			Postoperative Complications
		                        			;
		                        		
		                        			diagnostic imaging
		                        			;
		                        		
		                        			Staphylococcal Infections
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			Stomach Neoplasms
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Streptococcal Infections
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			Tomography, X-Ray Computed
		                        			
		                        		
		                        	
9.A case of left atria subendocardial thrombus with sick sinus syndrome.
Journal of Central South University(Medical Sciences) 2016;41(9):1005-1008
		                        		
		                        			
		                        			The clinical data for a patient with sick sinus syndrome was retrospectively analyzed. The patient was treated because of his heart palpitations and the increased chest pain. The patient admitted to the hospital under consideration for the left atrial tumor dependent on the echocardiography findings. After the CT scan and the dynamic ECG examination, the patient successfully underwent the left atrial tumor resection, atrial septal repair and cardiac pacing lead installation. The postoperative pathological diagnosis showed that the infective endocarditis and left atrial thrombus in left atrium was cured. The patient was discharged after postoperative anti-inflammatory therapy. By analyzing the reasons for misdignosis before or during surgery, the possible mechanisms for left atrial subendocardial thrombus have been found. This study suggests that it is necessary to combine imaging diagnosis and clinical observations to distinguish tumor from excrescence.
		                        		
		                        		
		                        		
		                        			Anti-Inflammatory Agents
		                        			;
		                        		
		                        			therapeutic use
		                        			;
		                        		
		                        			Arrhythmias, Cardiac
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Atrial Septum
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Computed Tomography Angiography
		                        			;
		                        		
		                        			Diagnosis, Differential
		                        			;
		                        		
		                        			Diagnostic Errors
		                        			;
		                        		
		                        			Echocardiography
		                        			;
		                        		
		                        			Endocarditis
		                        			;
		                        		
		                        			diagnosis
		                        			;
		                        		
		                        			therapy
		                        			;
		                        		
		                        			Heart Atria
		                        			;
		                        		
		                        			diagnostic imaging
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Heart Diseases
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Heart Neoplasms
		                        			;
		                        		
		                        			complications
		                        			;
		                        		
		                        			diagnostic imaging
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Pacemaker, Artificial
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Sick Sinus Syndrome
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Thrombosis
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			surgery
		                        			
		                        		
		                        	
10.Coronary Artery Imaging in Children.
Korean Journal of Radiology 2015;16(2):239-250
		                        		
		                        			
		                        			Coronary artery problems in children usually have a significant impact on both short-term and long-term outcomes. Early and accurate diagnosis, therefore, is crucial but technically challenging due to the small size of the coronary artery, high heart rates, and limited cooperation of children. Coronary artery visibility on CT and MRI in children is considerably improved with recent technical advancements. Consequently, CT and MRI are increasingly used for evaluating various congenital and acquired coronary artery abnormalities in children, such as coronary artery anomalies, aberrant coronary artery anatomy specific to congenital heart disease, Kawasaki disease, Williams syndrome, and cardiac allograft vasculopathy.
		                        		
		                        		
		                        		
		                        			Child
		                        			;
		                        		
		                        			Child, Preschool
		                        			;
		                        		
		                        			Coronary Angiography/*methods
		                        			;
		                        		
		                        			Coronary Vessel Anomalies/*radiography
		                        			;
		                        		
		                        			Coronary Vessels/*radiography
		                        			;
		                        		
		                        			Diagnostic Imaging
		                        			;
		                        		
		                        			Echocardiography/methods
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Heart Defects, Congenital/radiography
		                        			;
		                        		
		                        			Heart Diseases/diagnosis/*radiography
		                        			;
		                        		
		                        			Heart Rate
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Magnetic Resonance Angiography/*methods
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Mucocutaneous Lymph Node Syndrome/radiography
		                        			;
		                        		
		                        			Tomography, X-Ray Computed/methods
		                        			
		                        		
		                        	
            
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