Objective To explore the comorbidity patterns of different gender patients with chronic obstructive pulmonary disease(COPD)and provide theoretical basis for the hierarchical management of COPD patients.Methods The patients with chronic obstructive pulmonary disease from December 2011 to May 2020 in the Second Hospital of Shanxi Medical University were selected as the study subjects.The cross-sectional diagnostic information of patients was collected to establish a comorbidity network.The community of the comorbidity network was divided by Louvain method,and the comorbidity types,combinations and prevalence rates of patients with different genders were analyzed and compared.Results Our study manifested that there were differences in the prevalence of single chronic disease and comorbidity in patients with different genders.The corresponding comorbidity network and community structure of each patient group were also different.Conclusion The comorbidity network of male patients is more concentrated and complex than that of female patients.The comorbidity pattern of male patients is more complex and diverse than that of female patients,and the relationship between diseases is closer.It verifies that the comorbidity pattern of different gender patients is different.In patients with chronic obstructive pulmonary disease,more attention should be paid to male patients in order to reduce the incidence of comorbidity.