Objective To explore the effect of evidence-based health education combined with non-invasive positive pressure ventilation on the clinical efficacy of menopausal women with chronic obstructive pulmonary disease(COPD)and respiratory failure.Methods From February 2021 to February 2024,100 patients with menopausal COPD complicated with respiratory failure admitted to Wenzhou TCM Hospital were observed.According to the different intervention methods,100 patients were divided into routine group and study group,with 50 patients in each group.The patients in routine group were given routine intervention combined with non-invasive positive pressure ventilation,and the patients in study group were given health education under the evidence-based concept on the basis of routine group.The blood gas index,psychological state,general comfort question naire(GCQ)and Pittsburgh sleep quality index(PSQI)scores,treatment effect and complications were compared between two groups.Results Before intervention,insignificant changes existed in arterial partial pressure of carbon dioxide(PaCO2),arterial oxygen partial pressure(PaO2),and oxygen saturation of blood(SaO2)levels between both groups(P＞0.05).After the intervention,the PaCO2 of study group fell below than that of routine group,while PaO2 and SaO2 soared beyond than those of routine group(P＜0.05).Before intervention,no variance noted in self-rating depression scale(SDS)and self-rating anxiety scale(SAS)scores in both groups(P＞0.05).After the intervention,the SDS score points and SAS score points of study group were lower than those of routine group,and were statistically different(P＜0.05).Before intervention,there was no difference in GCQ and PSQI scores between two groups(P＞0.05).After intervention,The study group exhibited a superior GCQ score compared to routine group,coupled with an inferior PSQI score(P＜0.05).Comparing the ratings,the study group achieved a slightly higher proficiency rate(92％ vs.84％ )yet no significant disparity emerged(P＞0.05).Study group's complication rate at 4.00％ was significantly lower than routine group's at 16.00％ .Statistically significant difference observed(P＜0.05).Conclusion Under the concept of evidence-based health education combined with non-invasive positive pressure ventilation,the blood gas index,anxiety,depression and sleep quality of patients with climacteric chronic obstructive pulmonary disease and respiratory failure were significantly improved,which could reduce the occurrence of complications.

Objective:To investigate the clinical manifestations and characteristics of tracheobronchial foreign bodies in children, and improve the diagnosis and treatment of foreign bodies.Methods:A retrospective analysis was performed on the clinical data of children with tracheobronchial foreign bodies confirmed by fiberoptic bronchoscopy between January 2010 to December 2019.The children with tracheobronchial foreign body who were treated in the Maternal and Child Health Hospital of Gansu Province.Results:A total of 967 cases were operated by soft electronic bronchoscope, and foreign bodies were removed by means of foreign body forceps or nets.Among them, 19 cases(3 cases with subglottic foreign bodies, one with row of pins, and the rest 15 cases with foreign bodies completely wrapped by granulation)were not removed, two cases were spontaneously coughed, and 946 cases (97.8%)were removed.Bronchial foreign bodies in children were more common in boys, with the ratio of male to female being 2.14∶1.The main age of onset was 1-3 years old(88.8%). The incidence was slightly higher in rural areas than that in urban areas(46.5% in urban areas, 53.5% in rural areas). Foreign bodies were inhaled most in March and least in June.From the perspective of season, winter and spring were more than summer and autumn.The foreign body types inhaled were mainly exogenous plant foreign body, accounting for 93.0%, among which peanut(31.7%)and melon seeds(19.2%)were the most common.The duration of foreign body inhalation was up to 347 cases(35.9%)in 1-3 days.There were 501 cases(51.8%)with endoscopic endobronchial inflammation, and 196 cases of children with varying degrees of granulomatous hyperplasia, accounting for 39.1% and 20.3% of the total.The foreign body in the right bronchus accounted for 50.0% and the left bronchus for 43.7%.There were 793 cases confirmed by imaging, with a positive rate of 81.9%, and 90.9% confirmed by CT.Conclusion:About 88.8% of tracheobronchial foreign bodies occurred in 1 to 3 years of age.The occurrence of foreign bodies had obvious gender, urban-rural and seasonal distribution characteristics, and more cases were male, in rural and winter as well as spring.

Objective:To observe the clinical characteristics and reproductive outcome of patients with globozoospermia syndrome (also called round-headed spermatozoa).Methods:The data of 5 patients with round-headed spermatozoa and 20 healthy men in the reproductive center of Shanxi Maternal and Child Hospital and Shanxi People′s Hospital from July 2016 to March 2020 were collected. Among them, the wife was healthy. The peripheral blood chromosome, AZF gene, semen routine and morphology, sex hormone series were detected for the man, and the outcome of intracytoplasmic sperm injection (ICSI) was observed for the patients.Results:The average length of infertility in 5 patients with round-headed sperm was (4.4±1.8)years, and the round-headed sperm rate of 5 patients were all over 95% (including 1 case with round-headed sperm rate of 99%, 3 cases with round-headed sperm rate of 98%, and 1 case with round-headed sperm rate of 96%). The chromosome, AZF gene of 5 patients were normal. The sperm motility [progressive motility(PR) rate+ non progressive motility (NP) rate] of patients with globozoospermia syndrome was significantly lower than that of the healthy control group ( P<0.05). There was no significant difference in sex hormone, sperm count, sperm density, PR(%) and sperm DNA fragmentation rate compared with normal fertility group ( P>0.05). All the 5 patients were treated by assisted reproductive technology with ICSI. Two patients were pregnant, including one patient with abortion and one patient with singleton. Conclusions:There are no other abnormal phenotypes in patients with round-headed spermatozoa except for the low morphology and motility of round headed spermatozoa. Assisted reproductive technology may be an effective way to assist pregnancy.