Atypical sensory responsivity is widely reported in autistic individuals and is related to elevated functional difficulties. Dynamically, altered initial responses and/or habituation rates could underlie their atypical averaged responses to repeated sensory stimuli. In this study we aimed to measure the arousal level in response to different types of auditory stimuli and the dynamic change of atypical arousal level using pupillometry in autistic children. In Experiment 1, 43 autistic children and 49 neurotypical (NT) children were asked to passively listen to a mild sound and an aversive sound repeatedly. In Experiment 2, 39 autistic children and 44 NT children who went through Experiment 1 listened to a gradually emerging non-startling sound and a suddenly emerging startling sound in a random order. We found that the autistic group showed hyper-arousal in response to the aversive sound and the startling sound as reflected by their larger change in pupil area. In comparison, these autistic children demonstrated normal arousal in response to the mild sound and the non-startling sound. Dynamically, the autistic group had a larger peak pupil area change than the NT group in the first trial and a normal habituation rate to the aversive sound. In summary, our results suggest hyper-arousal to aversive and startling stimuli and the role of larger initial responses in hyper-arousal in autism. Minimizing aversive and startling sensory stimuli or gradually increasing the volume of aversive auditory stimuli to allow autistic children to adapt using the principle of habituation is recommended to reduce the arousal level and problematic behaviors of autistic children.
Humans ; Male ; Child ; Female ; Acoustic Stimulation ; Autistic Disorder/physiopathology* ; Arousal/physiology* ; Pupil/physiology* ; Habituation, Psychophysiologic/physiology* ; Auditory Perception ; Child, Preschool

Efficient behavioral assays are crucial for understanding the neural mechanisms of cognitive functions. Here, we designed a high-throughput automatic training system for spatial cognition (HASS) for free-moving mice. Mice were trained to return to the home arm and remain there during a delay period. Software was designed to enable automatic training in all its phases, including habituation, shaping, and learning. Using this system, we trained mice to successfully perform a spatially delayed nonmatch to sample task, which tested spatial cognition, working memory, and decision making. Performance depended on the delay duration, which is a hallmark of working memory tasks. The HASS enabled a human operator to train more than six mice simultaneously with minimal intervention, therefore greatly enhancing experimental efficiency and minimizing stress to the mice. Combined with the optogenetic method and neurophysiological techniques, the HASS will be useful in deciphering the neural circuitry underlying spatial cognition.
Animals ; Automation, Laboratory ; instrumentation ; Behavior, Animal ; Equipment Design ; Habituation, Psychophysiologic ; Male ; Memory, Short-Term ; Mice, Inbred C57BL ; Spatial Memory

INTRODUCTIONThis study evaluated the efficacy of tinnitus retraining therapy (TRT) in habituating patients with tinnitus.

MATERIALS AND METHODSThis is a retrospective review of patients who underwent TRT in a tertiary referral Otorhinolaryngology unit. Patients were followed up with structured interviews with the aid of questionnaire forms. Habituation following TRT was evaluated.

RESULTSA total of 702 patients were included (55% male, 45% female). Habituation of reaction to tinnitus and habituation of perception were analysed. Average duration of follow up was 33 months. In total, 68% of patients described improvement in annoyance following TRT. Of these patients, 80% of them described habituation of perception as well. There was no statistical difference in gender and age between patients who did and did not respond to TRT. However, duration of treatment was significantly longer in patients who habituated (P <0.05). Patients who adopted treatment strategies recommended based on Jastreboff's TRT categories were also found to have higher success rates compared to those who refused.

CONCLUSIONThe goal of TRT is to achieve habituation of reaction to tinnitus. Habituation of perception is often a secondary result of sufficiently habituated response. From our study, more than two thirds of patients with tinnitus achieved habituation of reaction and of these, the majority also habituated to awareness of the tinnitus.

Female ; Habituation, Psychophysiologic ; Humans ; Male ; Medical Audit ; Qualitative Research ; Retrospective Studies ; Tinnitus ; psychology ; therapy ; Treatment Outcome