Objective To analyze the epidemiological characteristics of hand-foot-mouth disease (HFMD) in Yangpu District of Shanghai from 2006 to 2015,and to explore the current epidemic situation of HFMD so as to master the trend thereof.Methods The descriptive epidemiological method was applied in analyzing and statistics for the monitored data of HFMD in Yangpu District of Shanghai from 2006 to 2015.Results A total of 11 239 cases of HFMD were reported in Yangpu District from 2006 to 2015, which peaked from April to July.Among the 11 communities of Yangpu District, Jiangpu community and Yinhang community were the ones with more cases.The main patients were kindergarten kids below five years of age as well as children living separately in this area.The relevant results of etiological detection from 2010 to 2015 showed that the rate of patients infected by enteroviruses other than enterovirus EV71 and enterovirus CA16 rose constantly and exceeded the rate of EV71-and CA16-infected patients.Conclusion The HFMD in Yangpu District had distinct seasonal features as well as features of resident crowds.It is recommended that relevant monitoring and preventive work should be done for susceptible children during peak onsets thereof.