Purpose: The purpose of this study was to investigate the influence of clinical nurses' nursing character, organizational communication satisfaction and organizational commitment on quality of nursing service. Methods: This study used a descriptive research design. Data were collected from 209 general nurses working in a tertiary hospitals in D city using self-report questionnaires from November 28 to December 14, 2022. The collected data were analyzed using descriptive statistics, Independent t-test, ANOVA, Scheffé test, Pearson correlation, and multiple regression analysis using SPSS/WIN 23.0 program. Results: There was a significant positive correlation between nursing character, organizational communication satisfaction, organizational commitment, and quality of nursing services. The regression analysis showed nursing character (β=.75, p<.001), organizational communication satisfaction (β=.12, p=.034) significantly influenced quality of nursing service, and explained 64.0% of the quality of nursing service. Conclusion The findings indicate that the quality of nursing service can be improved by raising nursing character and organizational communication satisfaction. Therefore, to improve the quality of nursing services, repeated and continuous implementation of training programs, including education to enhance nursing character, is necessary. Additionally, it is essential to develop and apply a programs to strengthen organizational communication satisfaction.

Purpose: The purpose of this study was to investigate the influence of clinical nurses' nursing character, organizational communication satisfaction and organizational commitment on quality of nursing service. Methods: This study used a descriptive research design. Data were collected from 209 general nurses working in a tertiary hospitals in D city using self-report questionnaires from November 28 to December 14, 2022. The collected data were analyzed using descriptive statistics, Independent t-test, ANOVA, Scheffé test, Pearson correlation, and multiple regression analysis using SPSS/WIN 23.0 program. Results: There was a significant positive correlation between nursing character, organizational communication satisfaction, organizational commitment, and quality of nursing services. The regression analysis showed nursing character (β=.75, p<.001), organizational communication satisfaction (β=.12, p=.034) significantly influenced quality of nursing service, and explained 64.0% of the quality of nursing service. Conclusion The findings indicate that the quality of nursing service can be improved by raising nursing character and organizational communication satisfaction. Therefore, to improve the quality of nursing services, repeated and continuous implementation of training programs, including education to enhance nursing character, is necessary. Additionally, it is essential to develop and apply a programs to strengthen organizational communication satisfaction.

Purpose: The purpose of this study was to investigate the influence of clinical nurses' nursing character, organizational communication satisfaction and organizational commitment on quality of nursing service. Methods: This study used a descriptive research design. Data were collected from 209 general nurses working in a tertiary hospitals in D city using self-report questionnaires from November 28 to December 14, 2022. The collected data were analyzed using descriptive statistics, Independent t-test, ANOVA, Scheffé test, Pearson correlation, and multiple regression analysis using SPSS/WIN 23.0 program. Results: There was a significant positive correlation between nursing character, organizational communication satisfaction, organizational commitment, and quality of nursing services. The regression analysis showed nursing character (β=.75, p<.001), organizational communication satisfaction (β=.12, p=.034) significantly influenced quality of nursing service, and explained 64.0% of the quality of nursing service. Conclusion The findings indicate that the quality of nursing service can be improved by raising nursing character and organizational communication satisfaction. Therefore, to improve the quality of nursing services, repeated and continuous implementation of training programs, including education to enhance nursing character, is necessary. Additionally, it is essential to develop and apply a programs to strengthen organizational communication satisfaction.

Purpose: The purpose of this study was to investigate the influence of clinical nurses' nursing character, organizational communication satisfaction and organizational commitment on quality of nursing service. Methods: This study used a descriptive research design. Data were collected from 209 general nurses working in a tertiary hospitals in D city using self-report questionnaires from November 28 to December 14, 2022. The collected data were analyzed using descriptive statistics, Independent t-test, ANOVA, Scheffé test, Pearson correlation, and multiple regression analysis using SPSS/WIN 23.0 program. Results: There was a significant positive correlation between nursing character, organizational communication satisfaction, organizational commitment, and quality of nursing services. The regression analysis showed nursing character (β=.75, p<.001), organizational communication satisfaction (β=.12, p=.034) significantly influenced quality of nursing service, and explained 64.0% of the quality of nursing service. Conclusion The findings indicate that the quality of nursing service can be improved by raising nursing character and organizational communication satisfaction. Therefore, to improve the quality of nursing services, repeated and continuous implementation of training programs, including education to enhance nursing character, is necessary. Additionally, it is essential to develop and apply a programs to strengthen organizational communication satisfaction.

Purpose: This study aimed to identify the effect of integrated nursing using cognicise and neurofeedback on cognition and ⍺ waves among elderly individuals. Methods: This quasi-experimental single group pretest-posttest study included 29 Korean adults aged 65 years or older who participated at a senior welfare center in Y city from February to May 2019. Each integrated nursing session consisted of cognicise (10 minutes) and neurofeedback (20 minutes). Subjects participated twice a week for 10 weeks. Structured questionnaires to assess participants' general characteristics and the Korean version of the Mini-Mental Status Examination for Dementia Screening (K-MMSE-DS) were applied. Alpha waves were measured using BrainMaster. Results: Following the integrated nursing program, alpha waves improved in F3 (t=2.41, p=.023), C3 (t=3.00, p=.006), C4 (t=2.60, p=.015), P3 (t=2.43, p=.022), O1 (t=2.30, p=.029), T3 (t=3.05, p=.005), T4 (t=2.28, p=.030), T5 (t=2.91, p=.007), Fz (t=2.30, p=.029), Cz (t=2.73, p=.011), and Pz (t=2.23, p=.034). Most subjects experienced improvement in concentration after participating in the intervention. Conclusion This study provides evidence for the use of a neuroscientific approach including brain wave measurement to improve cognitive health among community-living elderly people.

Although various studies on predictive markers in the use of PD-1/PD-L1 inhibitors are in progress, only PD-L1 expression levels in tumor tissues are currently used. In the present study, we investigated whether baseline serum levels of IL-6 can predict the treatment response of patients with advanced non-small cell lung cancer (NSCLC) treated with PD-1/PD-L1 inhibitors. In our cohort of 125 NSCLC patients, the objective response rate (ORR) and disease control rate (DCR) were significantly higher in those with low IL-6 (<13.1 pg/ml) than those with high IL-6 (ORR 33.9% vs. 11.1%, p=0.003; DCR 80.6% vs. 34.9%, p<0.001). The median progression-free survival was 6.3 months (95% confidence interval [CI], 3.9–8.7) in the low IL-6 group, significantly longer than in the high IL-6 group (1.9 months, 95% CI, 1.6–2.2, p<0.001). The median overall survival in the low IL-6 group was significantly longer than in the high IL-6 group (not reached vs. 7.4 months, 95% CI, 4.8–10.0). Thus, baseline serum IL-6 levels could be a potential biomarker for predicting the efficacy and survival benefit of PD-1/PD-L1 inhibitors in NSCLC.

To determine the effect of the tumor necrosis factor-α (TNF-α) in odontoclast formation, we administrated a TNF-α inhibitor in rats with diabetes rats with periodontitis. The rats included in the study were divided into three groups: control rats without diabetes or periodontitis (the C group), rats with periodontitis and diabetes (the PD group), and rats with periodontitis and diabetes treated by infliximab, the TNF inhibitor (the PD+infliximab group). The PD and PD+ infliximab groups received intravenous administrations of streptozotocin (STZ, 50 mg/kg) to induce diabetes. After 7 days of STZ injections, the mandibular first molars were ligatured to induce periodontitis. The PD+infliximab group was intrapenitoneally administrated by infliximab (5 mg/kg). On days 3 and 20 after the ligature administration, odontoclast formation along root surfaces was evaluated by tartrate resistant acid phosphatase (TRAP) staining and cathepsin K immunohistochemistry. On day 3, the number of TRAP- and cathepsin K-positive cells increased more so in the PD group than in the C group. The PD+infliximab group showed a lower number of positive cells than the PD group. There was no difference in all the groups on day 20. On day 3, the cathepsin-K positive multinucleated and mononucleated cells were higher in the PD group than in the C group. The number of cathepsin-K positive multinucleated cells was lower in the PD+infliximab group than in the PD group. The PD group showed more cathepsin K-positive cells in the furcation and distal surfaces than the c group. The Cathepsin K-positive cells of the PD+infliximab group were lower than that of the PD group in furcation. These results suggest that TNF-α stimulates odontoclast formation in diabetes with periodontitis.
Acid Phosphatase ; Administration, Intravenous ; Animals ; Cathepsin K ; Cathepsins ; Immunohistochemistry ; Infliximab ; Ligation ; Molar ; Necrosis ; Osteoclasts* ; Periodontitis* ; Rats* ; Streptozocin

BACKGROUND: The appropriate procedures and equipment for the pretransfusion test are fundamental to a safe blood transfusion. The present study aimed to assess the current status of procedures and equipment for pretransfusion tests at small- and medium-sized medical institutions, as well as to use this basic raw data to better manage blood transfusions at these institutions. METHODS: Offline and online questionnaire surveys were performed at institutions that used between 24 and 1,000 units of blood products in 2014. A total of 338 institutions participated, and the survey results were subsequently analyzed. RESULTS: Among 307 institutions where on-site ABO blood typing was performed, 15.0%, 2.1%, and 43.5% did not conduct ABO serum typing, RhD typing, and irregular antibody screening tests, respectively, and 12.8% only conducted the saline phase for crossmatching. Moreover, among 338 institutions, only 66.7% of blood banks had centrifuges, 84.5% had 37℃ incubators, 41.1% had slide view boxes; in addition, 66.1% and 18.6% had refrigerators and deep freezers, respectively, for blood storage. CONCLUSION: Certain small- and medium-sized institutions did not have the essential equipment required to operate as blood banks. Moreover, they also needed to improve their testing procedures. To address these issues, the initiation of systematic training programs and the employment of institutional strategies are necessary to enhance testing procedures and equipment, respectively.
Blood Banks ; Blood Grouping and Crossmatching ; Blood Transfusion ; Education ; Employment ; Incubators ; Korea* ; Mass Screening

Two external quality assessment (EQA) trials of conventional newborn screening tests for phenylketonuria, galactosemia, congenital adrenal hyperplasia, maple syrup urine disease, homocystinuria, and congenital hypothyroidism, as well as newborn screening tests using tandem mass spectrometry, were performed in 2015. A total of 44 specimens in the form of dried blood spots were distributed to 16 laboratories and the response rate of these laboratories was 100%. The mean, standard deviation, coefficient of variation, median, and cut-offs were evaluated for each analyte in the newborn screening tests. Two EQA trials for the analyses of methylmalonic acid, vanillylmandelic acid, catecholamines, metanephrines, organic acids, and amino acids were also performed. A well-designed EQA program and continuous education would improve the performance of biochemical genetics tests.
Adrenal Hyperplasia, Congenital ; Amino Acids ; Catecholamines ; Congenital Hypothyroidism ; Education ; Galactosemias ; Homocystinuria ; Humans ; Infant, Newborn ; Korea* ; Maple Syrup Urine Disease ; Mass Screening ; Methylmalonic Acid ; Molecular Biology* ; Phenylketonurias ; Tandem Mass Spectrometry ; Vanilmandelic Acid

BACKGROUND: Cleanroom air is extremely dry, as it is maintained within 1 % of relative humidity. Few studies have assessed the dermatologic life quality of workers in ultralow-humidity environments. Therefore, we aimed to evaluate the dermatologic life quality of cleanroom workers using the Skindex-29, compared to those of non-cleanroom workers. METHODS: Study participants were 501 cleanroom workers and 157 non-cleanroom workers from a secondary battery factory, who underwent an employee health examination at a single university hospital from September 2014 to September 2015. Results of the self-administered Skindex-29, and McMonnies questionnaire were analyzed. Other information and disease history were also collected during physician's medical examination. Descriptive and multivariate logistic regression analysis were performed. RESULTS: The Skindex-29 score was significantly higher in cleanroom workers than in non-cleanroom workers for all domains, Symptom (16.0 ± 15.9 vs. 6.3 ± 10.2, p < 0.001), Emotion (11.3 ± 17.4 vs. 2.5 ± 7.4, p < 0.001), Function (5.2 ± 11.1 vs. 1.6 ± 4.0, p < 0.001), and Overall (10.8 ± 13.4 vs. 3.5 ± 6.2, p < 0.001). The Skindex-29 score of cleanroom workers was similar to that of patients with skin diseases such as psoriasis, other dermatitis, corns, alopecia etc. Among the cleanroom workers, 37 workers had one or more skin diseases. Among the risk factors, ‘working at cleanroom’, ‘possessing skin disease’ and ‘McMonnies score’ had significant strong correlations with Skindex-29 score, meanwhile age, sex, smoking, drinking and exercise had weak correlations with it.‘Working at cleanroom’ and ‘possessing skin disease’ had highest odds ratios with overall 14.0 (C.I.: 5.9–33.1) and 13.4 (C.I.: 4.5–29.2), and the lowest odds ratios with function domain 3.5(C.I.: 1.7–7.1) and 4.5(C.I.: 2.1–9.5), respectively. The McMonnies score had the highest odds ratio with overall, 6.9(C.I.: 4.5–10.8) and lowest odd ratio with emotion domain 4.2 (C.I.: 2.7–6.4). CONCLUSIONS: Dermatologic life quality among cleanroom workers in the secondary battery factory is shown to be lower than that among non-cleanroom workers in this study. The study suggests that the Skindex-29 may provide helpful information on the dermatologic life quality of cleanroom workers. Therefore, regarding evaluation of dermatologic life quality using Skindex-29, preventive care is necessary for cleanroom workers in ultralow humidity environment.
Alopecia ; Callosities ; Dermatitis ; Drinking ; Humans ; Humidity ; Logistic Models ; Occupational Health ; Odds Ratio ; Psoriasis ; Quality of Life* ; Risk Factors ; Skin ; Skin Diseases ; Smoke ; Smoking ; Zea mays