Objective To observe the value of 18F-fluoro-dihydroxy-phenylalanine(18F-FDOPA)PET/CT for evaluating the efficacy of radiochemotherapy for advanced glioma.Methods Data of 84 patients with advanced glioma who received precision radiotherapy combined with synchronous chemotherapy were retrospectively analyzed.The patients were divided into effective group(complete remission+partial remission+stable disease,n=60)and ineffective group(progressive disease,n=24)according to the efficacy of radiochemotherapy.18F-FDOPA PET/CT metabolic parameters of tumors,including tumor metabolic tumor volume(MTV),maximum standard uptake value(SUVmax)and mean standard uptake value(SUVmean)were compared between groups,also before and after radiochemotherapy within groups.Spearman correlation analysis was used to observe the correlations of metabolic parameters and the efficacy of radiochemotherapy.Results After radiochemotherapy,MTV,SUVmax and SUVmean of tumors in effective group were lower than those of tumors in ineffective group(all P＜0.05).Significant differences of metabolic parameters were found before and after radiochemotherapy in effective group(all P＜0.05).MTV,SUVmax and SUVmean of advanced glioma were negatively correlated with the efficacy of radiochemotherapy(r=-0.63,-0.52,-0.50,P＜0.001,P=0.007,P=0.010).Conclusion 18F-FDOPA PET/CT was helpful for evaluating the efficacy of radiochemotherapy for advanced glioma.

Objective:To explore the efficacy of combination drug therapy for chronic prostatitis .Methods:According to National Institute Health Chronic Prostatitis Syndrome Index (NIH‐CPSI) combined with the pre‐ and post‐ massage test (PPMT) and expressed prostatic secretion (EPS) routine examination ,the NIH classification and efficacy evaluation was conducted for 253 patients with chronic prostatitis .All the 253 cases were administered quinolone antibiotics for 2 to 4 weeks , and meanwhile were administered alpha blocker and prostat for 4 to 6 weeks .Results:According to NIH‐CPSI ,there were 23 (9 .1% ) cases of type Ⅱ ,109(43 .1% ) cases of type Ⅲ A and 121(47 .8% ) cases of type Ⅲ B among the 253 patients .After 6 weeks of treatment ,the patients were evaluated by CPSI and the results showed that the curative rate ,the remarkable effective rate ,the improving rate ,the ineffective rate ,the total effective rate was 18 .6% ,45 .5% ,14 .6% ,21 .3% ,and 77 .7% , respectively .The average WBC count in EPS was (5 .4 ± 1 .6)/HP after the treatment ,while it was (24 .6 ± 3 .8)/HP before the treatment .And the difference was statistically significant (P< 0 .05) .After the treatment ,23 patients with chronic bacterial prostatitis underwent bacterial culture by using PPMT ,19 of which turned negative with a turning negative rate of 82 .6% .Conclusions:NIH‐CPSI is a reliable method for efficacy evaluation .The combination of drugs ,including quinolone , alpha blockade and prostat ,shows satisfactory effect for the treatment of chronic prostatitis .