OBJECTIVE To study the effect of fluoropezil on embryo-fetal developmental toxicity and toxicokinetics in rabbits,and provide reference for clinical medication.METHODS According to the sequence of pregnancy,pregnant rabbits were divided into five groups:vehicle control group(1%hydroxy-propyl methylcellulose+1.5%polyethylene glycol 400 aqueous solution),positive control group(cyclo-phosphamide 18 mg·kg-1),and fluoropezil(3.6,9.0 and 22.5 mg·kg-1)groups.The vehicle control group and the fluoropezil groups were ig administrated on the 6th to 18th day of gestation(GD6-18)while the positive control group was ig given cyclophosphamide on GD6-20.The pregnant rabbits were sacri-ficed on GD28,and the embryo-fetal development was detected.Sex hormone levels of pregnant rabbits on GD5,GD18 and GD28 were detected by ELISA method.Blood samples with toxokinetics were collected for concomitant toxic generation at the first and last administration,and drug concentrations in fetal,placenta and amniotic fluid were detected with liquid chromatography tandem mass spectrometry(LC-MS/MS).RESULTS Fluoropezil 3.6,9.0 and 22.5 mg·kg-1 had no significant effect on body mass,mass gain,food consumption,pregnancy outcomes,fetal appearance,viscera,skeletal and physical growth and development of pregnant rabbits.Only on GD18 or GD28,the levels of follicle stimulating hormone,estra-diol and progesterone in each dose group fluctuated to some extent.The combined toxokinetics results indicated that fluoropezil could cross the placental barrier of the rabbits,but did not accumulate in preg-nant rabbits or fetuses.Fetal mass,crown-rump length and uterus mass in the cyclophosphamide group were lower than those in the vehicle control group.The appearance and bone of the cyclophos-phamide group were positive.CONCLUSION The no observed adverse effect level(NOAEL)of fluoro-pezil toxicity on rabbit embryo-fetal development is 22.5 mg·kg-1,which is 125 times of the effective dose.At the dosage level of 22.5 mg·kg-1,Cmax is 1093 μg·L-1,and AUC(0-24 h)6650 μg·h·L-1 on GD18.

Objective:This study aims to provide scientific evidence for scientific iodine supplementation through monitoring the iodine nutrition status of children aged 8 - 10 and pregnant women in Haikou City.Methods:From 2016 to 2020, monitoring sites were selected in Longhua, Meilan, Qiongshan and Xiuying districts of Haikou City according to the requirements of the "Hainan Iodine Deficiency Disorders Monitoring Program". The iodine contents of drinking water, household edible salt and urinary iodine contents of children aged 8 - 10 and pregnant women were determined and analyzed.Results:The median iodine content of 388 drinking water samples was 5.60 μg/L, the median salt iodine content of 6 000 household edible salt samples was 25.70 mg/kg, the coverage rate of iodized salt was 98.65% (5 919/6 000), the qualified rate of iodized salt was 98.36% (5 822/5 919) and the consumption rate of qualified iodized salt was 97.03% (5 822/6 000). The median urinary iodine content of 4 000 children aged 8 - 10 was 181.68 μg/L and the median urinary iodine content of 2 000 pregnant women was 130.70 μg/L.Conclusions:The external environment of Haikou is iodine deficient. The iodine nutrition of children is generally in an appropriate state, and that of pregnant women is generally insufficient. While implementing the salt iodization policy, we should strengthen the monitoring of iodine nutrition among people and spreading iodine nutrition knowledge among residents, providing classified guidance and scientific iodine supplementation, so as to achieve the goal of continuous elimination of iodine deficiency disorders.

ObjectiveTo explore the status of chronic disease resource utilization and medication adherence among elder patients with primary hypertension in minority areas, and to analyze the influence of chronic disease resource utilization on medication adherence.Methods By convenience sampling method, from April to May 2016, elder patients with primary hypertension were selected from 6 communities in central zone and north zone in Xi'ning city, and were surveyed by questionnaire on chronic disease resource and Morisky Questionnaire.Results Scores of chronic disease resource utilization among elderly patients with primary hypertension were (68.72±10.26), with scores of various dimensions in descending order as follows: medical staff, family & friends, self-adjustment, media policy, social organizations, and community neighborhood. Scores of medication adherence were (11.32±3.52); medication adherence was positively correlated with chronic disease resource utilization (P<0.05).Conclusions Chronic disease resource utilization and medication adherence among elder patients with primary hypertension in minority areas are in the medium level. The higher level chronic disease resource utilization is, the higher level medication adherence is. Medication adherence among elder patients with primary hypertension in minority areas can be improved by bettering resource utilization of the patients, so that treatment effect can be ensured.