In recent years, with the changes in living standards and dietary structure, the incidence of non-alcoholic fatty liver disease has been increasing year by year in China, and the incidence rate in the general population is as high as 29.81%. An increasingly epidemiological evidence suggests that non-alcoholic fatty liver disease has become one of the causes of increasing liver cirrhosis and liver cancer. However, its etiology and pathogenesis are complex and have not yet been fully elucidated. Therefore, establishing an appropriate non-alcoholic fatty liver disease animal models for pre-clinical research is essential to elucidate its pathogenesis. This article summarizes the latest research progress of non-alcoholic fatty liver disease animal models, which are common at home and abroad in recent years.

Objective To evaluate the influence of hyperlipidemia factor on ephedrine-treated hy-potension in the patients undergoing epidural anesthesia. Methods Patients scheduled for elective hyster-ectomy with epidural anesthesia, were divided into normal blood lipid group and hyperlipidemia group ac-cording to the fasting blood lipid level. Epidural puncture was performed at L1,2after replacing the cumula-tive body fluid loss. The hypotensive response was defined as decrease in systolic pressure (SP)＜80% of the baseline value or SP＜90 mmHg. Effective pressor response was defined as increase in SP＞90% of the baseline value or SP＞100 mmHg.The initial dose of ephedrine was 0. 10 mg∕kg.Up-and-down sequential al-location was used to determine the dose of ephedrine. The difference between two successive doses was 0. 02 mg∕kg. Each time the dose increased∕decreased in the next patient according to whether SP increased or not. Probit analysis was used to determine the ED50, and 95% confidence interval (CI) of ephedrine in treating hypotension. Results A total of 114 patients were enrolled in this study, with 64 cases in normal blood lipid group and 50 cases in hyperlipidemia group. The rate of epidural anesthesia-induced hypotension was 22%(14 cases) in normal blood lipid group and 40%(20 cases) in hyperlipidemia group, and there was significant difference between two groups (P＜0. 05). The ED50(95% CI) of ephedrine in treating hypoten-sion was 0. 81 (0. 75-1. 03) mg∕kg and 1. 14 (1. 05-1. 31) mg∕kg in normal blood lipid group and hyper-lipidemia group, respectively, and there was significant difference between two groups ( P＜0. 05). Con-clusion Hyperlipidemia can not only be considered as a risk factor for epidural anesthesia-induced hypo-tension, but also markedly decease pressor responses to ephedrine for the female patients undergoing low epidural anesthesia.

Objective To investigate the status of internet addiction among adolescent students of Tianjin and analyze its related factors.Methods Stratification cluster random sampling method was used in this questionnaire survey among nine schools of Tianjin.The data was analyzed by logistic regression with SPSS11.5.Results The results showed that the Family harmony(OR=0.433),good personal education achievement(0.645),and sports participation(0.705) were the protective factors,while the Family member accident(OR=1.735) was the risk factor for IAD in adolescent students.Good Family economic conditions(OR=0.793),Family harmony(0.778),good personal education achievement(0.787),and sports participation(0.750) were the protective factors,while subsidization(OR=1.404) and family member accident(1.244) were the risk factors for IAT in adolescent students.Conclusion Family has close relationship with the formation of adolescents' IAD.Besides,personal education achievement and sports participation also have good influence on the formation of IAD.

Objective To evaluate the relationship between Internet addiction disorder(IAD),Internet addiction tendency(IAT) and behavior type A of young students aged ≥16 years in urban districts,Tianjin.Based on the result,the intervention resolution suggestion was put forward.Methods 4 484students(male2 331,female2 153) anonymously completed the Questionnaire on Situation of Internet Using of Students compiled for this study and the Questionnaire on types of Northern Chinese adult's Behavior.All data was recorded with the evaluating system for adolescent Internet addiction.Result There are 306(6.82%) cases of IAD and 600(13.83%) of IAT among the students.The screened positive rate in boys was 9.87% for IAD and 15.66% for IAT,which significantly higher than those in girls(3.53%,10.92%).The rates in students with behavior type A and type M were the same but significantly higher than that in students with behavior type B.After weighing cases by power on learning stage and sex,the results showed the prevalent rates of IAD and IAT in students with behavior type A and type sub-A were significantly higher than those in students with behavior type M,type sub-B and type B.After weighing cases by power only on learning stage,the positive rates of IAD were higher in students with behavior type A(8.87% in high school students,11.11% in college students) than those in students with type M(7.77%,7.81%) and type B(4.35%,4.44%).Conclusions The results show a significant relationship between IA and behavior type A in students.It should be strengthened to take psychological intervention for young students,especially for students with high risk of IA and IAT in senior high schools.

Objective To know the prevalence and distribution of Internet Addiction Disorder(IAD) among the adolescent students in urban districts in Tianjin.Methods This survey was carried out during November,2006 to April,2007 with Stratified cluster random sampling method.8225 questionnaires were valid among 8694 participants.Xing Yi's IAD diagnosis standard was used on the survey.Internet Addiction Tendency(IAT)by our definition was those students who had 3 or 4 of 10 indicators.The national standard population proportion of school students from junior high school to college in 2000 were used in weighing cases by power.Results 1.The detection rates of IAD between students online 2,3 or 4 hours per day were significantly different of the check out rate of IAD from the students on-line 2,3,or 4 hours per day,except time factor in the indicators;2.The detection rates of IAD between students with different learning stage or education system were also significantly different;the highest rate was among the students at special technical secondary school(11.69%),then followed by technical college and college students(6.74% and 6.73%),and junior high school and senior high school students(5.98% and 5.95%).The detection rates of IAT were increased by learning stage;the lowest rate was 8.65% in junior high school students,followed by 12.11% in high school students,13.96% in technical secondary school students,15.58% in technical college students and 16.73% in college students;3.After weighing case by power on learning stage or education system,the total IAD prevalence was 6.90%,9.50% for boys and 4.17% for girls.Total IAT prevalence was 11.78%,14.43% for boys and 8.96% for girls;4.For students in area with higher economic level,the rates of IAD and IAT were 4.16% and 8.27%,respectively,lower than those in other economic levels;5.Both IAD and IAT prevalent rates were no significant difference between the key high schools and common high schools.Conclusion The students of special technical secondary schools are high risk population for IAD and IAT.Students in area with higher level of economic have lower rates of IAD and IAT.It is suggested that it is needed to carry out health education on Internet using among the adolescent students together with family,school and social good environment.