Over the past few years, the human virome and its complex interactions with microbial communities and the immune system have gained recognition as a crucial factor in human health. Individuals with compromised immune function encounter distinctive challenges due to their heightened vulnerability to a diverse range of infectious diseases. This review aims to comprehensively explore and analyze the growing evidence regarding the role of the virome in immunocompromised disease status. By surveying the latest literature, we present a detailed overview of virome alterations observed in various immunodeficiency conditions. We then delve into the influence and mechanisms of these virome changes on the pathogenesis of specific diseases in immunocompromised individuals. Furthermore, this review explores the clinical relevance of virome studies in the context of immunodeficiency, highlighting the potential diagnostic and therapeutic gains from a better understanding of virome contributions to disease manifestations.
Humans ; Viruses ; Virome ; Microbiota ; Immunologic Deficiency Syndromes

An unconstrained cardiac output detection system based on thoracic electrical impedance method and embedded technology is developed in this study. PWM function of PIC embedded MCU, PIC18F4520, and filter circuit are used to generate a constant current sinusoidal signal with a frequency of 50 kHz and a current RMS of 2 mA, which is applied as an exciting signal to the exciting electrodes located on the positions behind ears and on right lower abdomen. The thoracic electrical impedance is measured by the detecting electrodes pasted along the medial line on the front of the thorax, and is used to calculate cardiac output. A comparative experiment with the thoracic impedance method and the dye dilution method is carried out and the results are investigated. The experimental results show that the two methods have good consistency.
Cardiac Output ; Electric Impedance ; Electricity ; Electrodes ; Monitoring, Physiologic ; instrumentation ; Thorax