Objective : To investigate the effects of immunoglobulin gene superfamily 10 (IGSF10) on prolifera- tion，migration and invasion of lung adenocarcinoma cells． Methods : ioinformatics was applied to study the ex- pression levels of IGSF10 in tumor tissues and normal tissues． Western blot and quantitative real-time PCR ( qPCR) were used to detect the expression level of IGSF10 in lung adenocarcinoma cell lines and normal lung epi- thelial cells．Knockdown of IGSF10，the effect of knockdown of IGSF10 on proliferation，migration and invasion of lung adenocarcinoma A549 cells was examined using cell counting kit-8 ( CCK-8) ，Transwell migration and inva- sion assay，scratch assay and plate cloning assay．The effects of knockdown of IGSF10 on the expression of invasion and migration-related genes in A549 cells were examined by Western blot and qPCR assays. Results : IGSF10 ex- pression in lung adenocarcinoma tissues was lower than that in normal tissues (P ＜0. 05) ．IGSF10 expression in lung adenocarcinoma cell lines was lower than that in lung epithelial cells (P＜0. 05) ．Knockdown of IGSF10 pro- moted the ability of lung adenocarcinoma A549 cells to proliferate ，proliferation ，migration and invasion ( P < 0. 05) ．Knockdown of IGSF10 promoted the expression of regulatory epithelial-mesenchymal transition marker Neu- ral-cadherin (N-cadherin) and key transcription factors Snail family transcriptional repressor 1 (Snail) and Snail family transcriptional repressor 2 (Slug) (P＜0. 05) and inhibited the expression of Epithelial-cadherin (E-cad- herin) (P＜0. 05) ． Conclusion Knockdown of IGSF10 may promote proliferation，migration and invasion of lung adenocarcinoma cells through activation of Snail，Slug / E-cadherin signaling axis，and this result may provide a po- tential new target for clinical diagnosis and treatment of lung adenocarcinoma.

Hemodynamically unstable pelvic fracture is an important cause of trauma-related deaths and its treatment presents a major challenge for trauma surgery. Internal iliac artery devascularization including ligation and embolization of the internal iliac artery with occlusion of the internal iliac artery as their hemostatic mechanism, has been proved to be effective in controlling massive hemorrhage after pelvic fracture. Nevertheless, there still remain substantial differences in the understanding of internal iliac artery devascularization in clinical practice. Some and issues that should be paid attention to its emergency application in the management of hemodynamically unstable pelvic fracture have not been fully elucidated. To this end, the authors emphasized the efficacy and safety of internal iliac artery devascularization, its indications, and key points in implementation, aiming to promote its standardized application in the treatment of hemodynamically unstable pelvic fracture, thus improving treatment outcomes.

Patients with severe trauma require an extremely timely treatment and transfusion plays an irreplaceable role in the emergency treatment of such patients. An increasing number of evidence-based medicinal evidences and clinical practices suggest that patients with severe traumatic bleeding benefit from early transfusion of low-titer group O whole blood or hemostatic resuscitation with red blood cells, plasma and platelet of a balanced ratio. However, the current domestic mode of blood supply cannot fully meet the requirements of timely and effective blood transfusion for emergency treatment of patients with severe trauma in clinical practice. In order to solve the key problems in blood supply and blood transfusion strategies for emergency treatment of severe trauma, Branch of Clinical Transfusion Medicine of Chinese Medical Association, Group for Trauma Emergency Care and Multiple Injuries of Trauma Branch of Chinese Medical Association, Young Scholar Group of Disaster Medicine Branch of Chinese Medical Association organized domestic experts of blood transfusion medicine and trauma treatment to jointly formulate Chinese expert consensus on blood support mode and blood transfusion strategies for emergency treatment of severe trauma patients ( version 2024). Based on the evidence-based medical evidence and Delphi method of expert consultation and voting, 10 recommendations were put forward from two aspects of blood support mode and transfusion strategies, aiming to provide a reference for transfusion resuscitation in the emergency treatment of severe trauma and further improve the success rate of treatment of patients with severe trauma.

The purpose of this paper is to systematically summarize the gene polymorphisms associated with osteoporosis(OP)susceptibility in Zhuang ethnic group in Guangxi.These genes mainly encode vitamin D receptor,estrogen receptor,calcitonin receptor,and adiponectin.The genotype and allele distribution frequency were compared between Zhuang ethnic group and other ethnic groups,which can clarify the existing genes and the potential gene polymorphism associated with OP in Zhuang ethnic group.The findings provide a representative solution for the subsequent research on the genes associated with OP susceptibility in ethnic minorities.

During coronavirus disease 2019 epidemic, the treatment of severe trauma has been impacted. The Consensus on emergency surgery and infection prevention and control for severe trauma patients with 2019 novel corona virus pneumonia was published online on February 12, 2020, providing a strong guidance for the emergency treatment of severe trauma and the self-protection of medical staffs in the early stage of the epidemic. With the Joint Prevention and Control Mechanism of the State Council renaming "novel coronavirus pneumonia" to "novel coronavirus infection" and the infection being managed with measures against class B infectious diseases since January 8, 2023, the consensus published in 2020 is no longer applicable to the emergency treatment of severe trauma in the new stage of epidemic prevention and control. In this context, led by the Chinese Traumatology Association, Chinese Trauma Surgeon Association, Trauma Medicine Branch of Chinese International Exchange and Promotive Association for Medical and Health Care, and Editorial Board of Chinese Journal of Traumatology, the Chinese expert consensus on emergency surgery for severe trauma and infection prevention during coronavirus disease 2019 epidemic ( version 2023) is formulated to ensure the effectiveness and safety in the treatment of severe trauma in the new stage. Based on the policy of the Joint Prevention and Control Mechanism of the State Council and by using evidence-based medical evidence as well as Delphi expert consultation and voting, 16 recommendations are put forward from the four aspects of the related definitions, infection prevention, preoperative assessment and preparation, emergency operation and postoperative management, hoping to provide a reference for severe trauma care in the new stage of the epidemic prevention and control.

Medical record writing in trauma surgery differs from that of conventional surgery. The medical records in trauma surgery encompass the entire process of trauma management, serving as an indication of expertise in trauma management and treatment effectiveness. At present, most medical records in trauma surgery are written in the conventional writing mode of various surgical specialties, which fails to indicate the overall injury situation of trauma patients and the process of diagnosis and treatment, resulting in unevenly qualified medical records in trauma surgery, which hinders trauma treatment and academic exchange. Given that trauma assessment owns unique nuances, conventional physical examination methods are not entirely applicable to trauma patients. Moreover, with the advancement of diagnostic and therapeutic technologies, certain physical examination techniques and medical procedures that may induce pain, impede timely rescue, or even cause injury can be circumvented in clinical assessment. As theories, techniques, and disciplines in trauma care continue to develop, there arises a need for further standardization and uniformity in medical record writing in trauma surgery. By analyzing the special characteristics of medical record writing in trauma surgery, the authors sorted out and summarized the problems in medical record writing and put forward suggestions on improvement of medical records in trauma surgery to provide reference for standardization of medical record writing in trauma surgery and improvement of the comprehensive strength of trauma treatment.

Flail chest is a severe chest trauma that is commonly associated with lung contusion, resulting in acute respiratory distress syndrome and respiratory failure, which brings challenges in clinical management. It has become a clinical consensus that surgical treatment of flail chest can rapidly restore thoracic stability, eliminate paradoxical breathing, and maintain stability of respiratory and circulatory functions. However, non-surgical interventions continue to be crucial in further improving the prognosis of patients with flail chest, such as pain management and respiratory management. In this study, the authors review the research progress in pain control and respiratory management during comprehensive treatment of patients with flail chest for better understanding of pain management and lung injury care, which may provide references for clinical treatment and further improvement of clinical prognosis and quality of life for patients with flail chest.

Traumatic rib fractures are the most common injury in thoracic trauma. Previously，the patients with traumatic rib fractures were mostly treated non-surgically，of which 50%，especially those combined with flail chest presented chronic pain or chest wall deformities and over 30% had long-term disabilities，being unable to retain a full-time job. In the past two decades，thanks to the development of internal fixation material technology，the surgical treatment of rib fractures has achieved good outcomes. However，there are still some problems in clinical treatment，including inconsistency in surgical treatment and quality control in medical services. The current consensuses on the management of regional traumatic rib fractures published at home and abroad mainly focus on the guidance of the overall treatment decisions and plans，and relevant clinical guidelines abroad lacks progress in surgical treatment of rib fractures in recent years. Therefore，the Chinese Society of Traumatology affiliated to Chinese Medical Association and Chinese College of Trauma Surgeons affiliated to Chinese Medical Doctor Association，in conjunction with national multidisciplinary experts，formulate the Chinese Consensus for Surgical Treatment of Traumatic Rib Fractures（2021）following the principle of evidence-based medicine，scientific nature and practicality. This expert consensus puts forward some clear，applicable，and graded recommendations from aspects of preoperative imaging evaluation，surgical indications，timing of surgery，surgical methods，rib fracture sites for surgical fixation，internal fixation methods and material selections，treatment of combined injuries in rib fractures，in order to provide references for surgical treatment of traumatic rib fractures.

Objective:To explore the effect of diabetes specific Enteral Nutritional Suspension on patients with severe brain injury.Methods:from March 2018 to April 2021, 117 patients with severe brain injury were selected from the Department of Neurosurgery of Yantai Mountain hospital of Yantai city. They were divided into 2 groups according to the random number table. The control group received enteral nutrition (EN) preparation (n=59) , while the observation group was treated with diabetes specific Enteral Nutritional Suspension (n=58) for 2 weeks, and two groups of immunoglobulin A were compared. (IGA) , immunoglobulin G (IgG) , immunoglobulin M (IgM) , total cholesterol (TC) , low density lipoprotein (LDL) , triglyceride (TG) , glycosylated hemoglobin (HBAIC) , fasting blood glucose (FBG) , 2 h postprandial blood glucose (2hbg) and the positive rate of bacterial DNA in peripheral blood at each time period. The positive rate was analyzed by SPSS 22.0 software χ 2 test, repeated measurement was analyzed by analysis of variance, and pairwise comparison was performed by LSD-t test.Results:The positive rates of bacterial DNA in peripheral blood of the observation group were 10.34%, 5.17% and 0.00% on the 7th day and 14th day after treatment, which were lower than 25.42%, 16.95% and 8.47% in the control group (P = 0.034, 0.043 and 0.023) . 2 weeks after treatment, the levels of BG (7.46±1.22) mmol/L, FBG (5.26±1.11) mmol/L, HBAIC (6.33±0.45%) , TG (1.11±0.12) mmol/L, TC (4.22±0.68) mmol/L, LDL (1.39±0.13) mmol/L in the observation group were lower than those in the control group, 2hbg (10.69±1.57) mmol/L, FBG (8.18±1.46) mmol/L, HBAIC (7.46±0.34%) , TG (1.86±0.26) mmol/L, TC (6.65±1.17) mmol/L and LDL (2.79±0.41) mmol/L, ( P<0.001) , IgM, IgA and IgG were (1.57±0.26) g/L, (1.86±0.43) g/L, (10.13±1.46) g/L, and IgM, IgA and IgG were (1.86±0.47) g/L, (2.86±0.39) g/L, (13.28±1.96) g/L, respectively, 1 week after treatment. The improvement of all indexes were better than that of the control group The IgM, IgA and IgG of (0.86±0.13) g/L, (1.35±0.11) g/L, (8.66±1.57) g/L and 2 weeks after treatment were (1.10±0.11) g/L, (2.13±0.11) g/L and (10.45±1.46) g/L respectively ( P<0.001) . Conclusion:The special enteral nutrition suspension for diabetes patients with severe brain injury can improve the immune function and glucose and lipid metabolism of the body, and reduce the positive rate of bacterial DNA.

Objective:To evaluate the trauma center model in general hospitals for patients with severe trauma.Methods:The data of 1,248 patients with severe trauma (ISS≥16) were retrospectively analyzed who had been admitted to the trauma centers in 6 Chinese general hospitals from January 2019 through June 2020. They were 987 males and 261 females with an age of 50.4 years ± 15.4 years. Their injuries were caused by a traffic accident in 622 cases, falling from a height in 357 cases, a knife in 62 cases, and others (like a heavy object and fall) in 207 cases. Upon admission, their injury severity scores (ISS) were 24.9±8.5 and their Glasgow coma scores (GCS) 12.6±3.6. They were all treated in a scientific and standard manner by a multidisciplinary team at the trauma center of their specific general hospital. Recorded were deaths within 30 days after admission, 30-day mortality and causes of death.Results:All the patients were treated effectively. 101 deaths occurred within 30 days after admission, yielding a 30-day mortality of 8.1%. The main causes of death were severe craniocerebral injury in 56 cases, hemorrhagic shock in 26 cases, multi-organ failure in 11 cases and others in 8 cases.Conclusions:Establishment of trauma centers in China can make up for the disadvantage of over-division of clinical specialties in large general hospitals which has led to insufficient care for patients with severe trauma and multiple injuries. The trauma centers in general hospitals may be a feasible model to be popularized in treatment of patients with severe trauma and multiple injuries.