Objective:To investigate the effect of holographic meridian copper coin scraping therapy on limb swelling and pain after a pit viper bite and the changes of related laboratory indicators.Methods:Seventy-four patients with limb swelling and pain after a pit viper bite who received treatment at the Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University from May 2023 to October 2023 were included in this study. Using a case-control study design, these patients were divided into a study group (holographic meridian copper coin scraping therapy) and a control group (conventional intervention), with 37 patients in each group, according to the treatment methods. The clinical data (gender, age, body mass index, education level, time of admission, severity, bite site), the degree of limb swelling, Visual Analogue Scale score, laboratory indicators, and adverse reactions were compared between the two groups.Results:Before intervention, there was no statistically significant difference in the degree of limb swelling between the two groups ( P > 0.05). At 1, 3, and 7 days after intervention, the degree of swelling in the study group [(52.41 ± 4.07) mm, (33.07 ± 3.25) mm, (10.45 ± 2.13) mm] was significantly lower than that in the control group [(58.56 ± 4.30) mm, (40.26 ± 3.41) mm, (13.98 ± 2.77) mm, t = 6.32, 9.28, 6.15, P < 0.001, < 0.001, < 0.001). Before intervention, there was no statistically significant difference in Visual Analogue Scale score between the two groups ( P > 0.05). At 1, 3, and 7 days after intervention, the Visual Analogue Scale scores in the study group [(3.41 ± 1.18) points, (3.01 ± 1.05) points, (2.74 ± 0.72) points] were significantly lower than those in the control group [(3.98 ± 1.25) points, (3.52 ± 1.10) points, (3.18 ± 0.96) points, t = 2.01, 2.04, 2.23, P = 0.047, 0.045, 0.029]. There were no statistically significant differences in laboratory indicators between the two groups before and 1 day after intervention (all P > 0.05). At 3 and 7 days after intervention, the levels of creatine kinase [(231.25 ± 25.96) IU/L, (190.67 ± 21.03) IU/L], creatinine [(74.34 ± 7.91) μmol/L, (70.08 ± 7.54) μmol/L], creatine kinase isoenzyme [(16.61 ± 2.06) IU/L, (12.02 ± 1.74) IU/L], and C-reactive protein [(6.54 ± 1.18) mg/L, (4.10 ± 0.96) mg/L] in the study group were significantly lower than those in the control group [(260.48 ± 28.51) IU/L, (215.34 ± 24.25) IU/L, (79.10 ± 8.23) μmol/L, (74.33 ± 7.91) μmol/L, (19.33 ± 2.31) IU/L, (15.68 ± 1.95) IU/L, (7.30 ± 1.52) mg/L, (5.92 ± 1.23) mg/L, t = 4.61, 4.67, 2.53, 2.36, 5.34, 8.51, 2.40, 7.09, all P < 0.05]. No serious adverse reactions occurred in each group. Conclusion:The holographic meridian copper coin scraping therapy can rapidly reduce the degree of limb swelling in patients, alleviate pain, reduce muscle injury, and is highly safe.

Objective To retrospect the early programmed emergency care plan for patients with venomous snake bite,and provide evidence and experience for early emergency treatment in clinic. Methods Based on retrospective analysis,56 patients with venomous snake bite were collected from Hangzhou Traditional Chinese Medicine Hospital during March 2010 to March 2015 by using cluster sampling. The eligible participants should be treated by early programmed emergency care plan.Results Among all participants:51 patients were discharged from the hospital;three patients got better;two cases were died (i.e. one was bitten by Trimeresurus stejnegeri,and one was bitten by Agkistrodon acutus).Conclusions The early programmed emergency care plan for patients with venomous snake bite is beneficial and recommendable,and it is worth of promoting in clinical treatment.

Objective:To investigate the correlation between plasma homocysteine (Hcy) concentration and transient ischemic attack (TIA) and traditional vascular risk factors.Methods:The plasma Hcy concentrations of 112 patients with TIA and 62 controls were measured by fluorescenee polarization immunoassay.Hcy concentrations and related risk factors were analyzed.Results:The risk of TIA was increased significantly in plasma Hcy concentration 10.0 to 14.9 μmol/L group(OR=2.450,95% CI 1.091 to 5.502) and≥15.0 μmol/L group(OR=5.169,95% CI 2.096 to 12.746) compared with plasma Hcy concentration＜10.0 μmol/L group.Using TIA as the dependent wariable,various vascular risk factors (including plasma Hcy concentration) as the independent variable,logistic regression was analyzed.The result showed that the risk of TIA was increased significantly in plasma Hcy concentration＞10.0 μmol/L group compared with plasma Hcy concentration＜10.0 μmol/L group(OR=3.150,95% CI 1.380 to 7.192).Conclusions:Plasma Hcy concentration is an independent risk factor for TIA.