1.Prevention, diagnosis and treatment of perioperative complications of bariatric and metabolic surgery.
Haifu WU ; Ming ZHONG ; Di ZHOU ; Chenye SHI ; Heng JIAO ; Wei WU ; Xinxia CHANG ; Jing CANG ; Hua BIAN
Chinese Journal of Gastrointestinal Surgery 2017;20(4):393-397
		                        		
		                        			
		                        			Surgical operation in treating obesity and type 2 diabetes is popularizing rapidly in China. Correct prevention and recognition of perioperation-related operative complications is the premise of ensuring surgical safety. Familiar complications of the operation include deep venous thrombosis, pulmonary artery embolism, anastomotic bleeding, anastomotic fistula and marginal ulcer. The prevention of deep venous thrombosis is better than treatment. The concrete measures contain physical prophylaxis (graduated compression stocking and intermittent pneumatic compression leg sleeves) and drug prophylaxis (unfractionated heparin and low molecular heparin), and the treatment is mainly thrombolysis or operative thrombectomy. The treatment of pulmonary artery embolism includes remittance of pulmonary arterial hypertension, anticoagulation, thrombolysis, operative thrombectomy, interventional therapy and extracorporeal membrane oxygenation (ECMO). Hemorrhage is a rarely occurred but relatively serious complication after bariatric surgery. The primary cause of anastomotic bleeding after laparoscopic gastric bypass is incomplete hemostasis or weak laparoscopic repair. The common bleeding site in laparoscopic sleeve gastrectomy is gastric stump and close to partes pylorica, and the bleeding may be induced by malformation and weak repair technique. Patients with hemodynamic instability caused by active bleeding or excessive bleeding should timely received surgical treatment. Anastomotic fistula in gastric bypass can be divided into gastrointestinal anastomotic fistula and jejunum-jejunum anastomotic fistula. The treatment of postoperative anastomotic fistula should vary with each individual, and conservative treatment or operative treatment should be adopted. Anastomotic stenosis is mainly related to the operative techniques. Stenosis after sleeve gastrectomy often occurs in gastric angle, and the treatment methods include balloon dilatation and stent implantation, and surgical treatment should be performed when necessary. Marginal ulcer after gastric bypass is a kind of peptic ulcer occurring close to small intestine mucosa in the junction point of stomach and jejunum. Ulcer will also occur in the vestige stomach after laparoscopic sleeve gastrectomy, and the occurrence site locates mostly in the gastric antrum incisal margin. Preoperative anti-HP (helicobacter pylorus) therapy and postoperative continuous administration of proton pump inhibitor (PPI) for six months is the main means to prevent and treat marginal ulcer. For patients on whom conservative treatment is invalid, endoscopic repair or surgical repair should be considered. Different surgical procedures will generate different related operative complications. Fully understanding and effectively dealing with the complications of various surgical procedures through multidisciplinary cooperation is a guarantee for successful operation.
		                        		
		                        		
		                        		
		                        			Anastomosis, Surgical
		                        			;
		                        		
		                        			adverse effects
		                        			;
		                        		
		                        			Anticoagulants
		                        			;
		                        		
		                        			therapeutic use
		                        			;
		                        		
		                        			Bariatric Surgery
		                        			;
		                        		
		                        			adverse effects
		                        			;
		                        		
		                        			Catheterization
		                        			;
		                        		
		                        			China
		                        			;
		                        		
		                        			Conservative Treatment
		                        			;
		                        		
		                        			Constriction, Pathologic
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			therapy
		                        			;
		                        		
		                        			Digestive System Fistula
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			therapy
		                        			;
		                        		
		                        			Endoscopy, Gastrointestinal
		                        			;
		                        		
		                        			methods
		                        			;
		                        		
		                        			Extracorporeal Membrane Oxygenation
		                        			;
		                        		
		                        			Gastrectomy
		                        			;
		                        		
		                        			adverse effects
		                        			;
		                        		
		                        			Gastric Bypass
		                        			;
		                        		
		                        			adverse effects
		                        			;
		                        		
		                        			Gastric Mucosa
		                        			;
		                        		
		                        			pathology
		                        			;
		                        		
		                        			Gastric Stump
		                        			;
		                        		
		                        			physiopathology
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Gastrointestinal Hemorrhage
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			prevention & control
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Hemostasis, Surgical
		                        			;
		                        		
		                        			adverse effects
		                        			;
		                        		
		                        			methods
		                        			;
		                        		
		                        			Hemostatic Techniques
		                        			;
		                        		
		                        			Heparin
		                        			;
		                        		
		                        			therapeutic use
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Intermittent Pneumatic Compression Devices
		                        			;
		                        		
		                        			Intestine, Small
		                        			;
		                        		
		                        			pathology
		                        			;
		                        		
		                        			Laparoscopy
		                        			;
		                        		
		                        			adverse effects
		                        			;
		                        		
		                        			Margins of Excision
		                        			;
		                        		
		                        			Peptic Ulcer
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			therapy
		                        			;
		                        		
		                        			Postoperative Complications
		                        			;
		                        		
		                        			diagnosis
		                        			;
		                        		
		                        			prevention & control
		                        			;
		                        		
		                        			therapy
		                        			;
		                        		
		                        			Pulmonary Embolism
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			therapy
		                        			;
		                        		
		                        			Stents
		                        			;
		                        		
		                        			Stockings, Compression
		                        			;
		                        		
		                        			Thrombectomy
		                        			;
		                        		
		                        			Thrombolytic Therapy
		                        			;
		                        		
		                        			Venous Thrombosis
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			prevention & control
		                        			;
		                        		
		                        			therapy
		                        			
		                        		
		                        	
2.Can Glasgow-Blatchford Score and Pre-endoscopic Rockall Score Predict the Occurrence of Hypotension in Initially Normotensive Patients with Non-variceal Upper Gastrointestinal Bleeding?.
June Sung KIM ; Byuk Sung KO ; Chang Hwan SON ; Shin AHN ; Dong Woo SEO ; Yoon Seon LEE ; Jae Ho LEE ; Bum Jin OH ; Kyoung Soo LIM ; Won Young KIM
The Korean Journal of Gastroenterology 2016;67(1):16-21
		                        		
		                        			
		                        			BACKGROUND/AIMS: The aim of this study was to identify the ability of Glasgow-Blatchford score (GBS) and pre-endoscopic Rockall score (pre-E RS) to predict the occurrence of hypotension in patients with non-variceal upper gastrointestinal bleeding who are initially normotensive at emergency department. METHODS: Retrospective observational study was conducted at Asan Medical Center emergency department (ED) in patients who presented with non-variceal upper gastrointestinal bleeding from January 1, 2011 to December 31, 2013. Study population was divided according to the development of hypotension, and demographics, comorbidities, and laboratory findings were compared. GBS and pre-E RS were estimated to predict the occurrence of hypotension. RESULTS: A total of 747 patients with non-variceal upper gastrointestinal bleeding were included during the study period, and 120 (16.1%) patients developed hypotesion within 24 hours after ED admission. The median values GBS and pre-E RS were statistically different according to the occurrence of hypotension (8.0 vs. 10.0, 2.0 vs. 3.0, respectively; p<0.001). In the receiver operating characteristic curve analysis of hypotension development, the area under the curve of GBS and pre-E RS were 66% and 64%, respectively. The sensitivity and the specificity of GBS using optimal cut-off value were 81% and 46%, respectively, while those based on the pre-E RS were 74% and 46%, respectively. CONCLUSIONS: GBS and pre-E RS were both not sufficient for predicting the occurrence of hypotension in non-variceal upper gastrointestinal bleeding. Development of other scoring systems are needed.
		                        		
		                        		
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Area Under Curve
		                        			;
		                        		
		                        			Demography
		                        			;
		                        		
		                        			Emergency Service, Hospital
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Gastrointestinal Hemorrhage/complications/*diagnosis/pathology
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Hypotension/epidemiology/*etiology
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Predictive Value of Tests
		                        			;
		                        		
		                        			ROC Curve
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Severity of Illness Index
		                        			;
		                        		
		                        			Upper Gastrointestinal Tract
		                        			
		                        		
		                        	
3.Emergency endoscopic variceal ligation in cirrhotic patients with blood clots in the stomach but no active bleeding or stigmata increases the risk of rebleeding.
Su Jin KIM ; Cheol Woong CHOI ; Dae Hwan KANG ; Hyung Wook KIM ; Su Bum PARK ; Young Mi HONG ; Ki Tae YOON ; Mong CHO ; Hyung Seok NAM ; SM Bakhtiar UI ISLAM
Clinical and Molecular Hepatology 2016;22(4):466-476
		                        		
		                        			
		                        			BACKGROUND/AIMS: This study aimed to evaluate the efficacy and safety of emergency variceal ligation for the prevention of rebleeding in cirrhotic patients who are found on initial endoscopy to have blood clots in the stomach but no actively bleeding esophageal and gastric varices or stigmata. METHODS: This study included 28 cirrhotic patients who underwent emergency prophylactic EVL and 41 who underwent an elective intervention between January 2009 and June 2014. Clinical outcomes were analyzed, including the rebleeding, 6-week mortality, and rebleeding-free survival rates. RESULTS: The rebleeding rate was higher in the emergency than in the elective group (28.6% vs. 7.3%, P=0.041). Multivariate analysis showed that emergency prophylactic EVL (odds ratio [OR] = 7.4, 95% confidence interval [CI]=1.634.8, P=0.012) and Child-Pugh score C (OR=10.6, 95% CI=1.4-80.8, P=0.022) were associated with rebleeding. In the emergency group, the gastric varices were associated with rebleeding (OR=12.0, 95% CI=1.7-83.5, P=0.012). CONCLUSIONS: Emergency EVL may be associated with variceal rebleeding when blood clots are present in the stomach without active esophageal and gastric variceal bleeding or stigmata. Elective intervention should be considered as a safer strategy for preventing variceal rebleeding in this situation.
		                        		
		                        		
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Emergency Medical Services
		                        			;
		                        		
		                        			Endoscopy, Digestive System
		                        			;
		                        		
		                        			Esophageal and Gastric Varices/complications/*diagnosis
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Gastrointestinal Hemorrhage/mortality/*prevention & control
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Kaplan-Meier Estimate
		                        			;
		                        		
		                        			Liver Cirrhosis/complications/*diagnosis
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Multivariate Analysis
		                        			;
		                        		
		                        			Odds Ratio
		                        			;
		                        		
		                        			Recurrence
		                        			;
		                        		
		                        			Risk Factors
		                        			;
		                        		
		                        			Severity of Illness Index
		                        			;
		                        		
		                        			Stomach/pathology
		                        			;
		                        		
		                        			Survival Rate
		                        			;
		                        		
		                        			Thrombosis
		                        			
		                        		
		                        	
4.A Case of Spontaneous Bleeding of Multiple Lumbar Arteries in a Patient with Liver Cirrhosis.
Jong Sam HONG ; Woo Jin JEONG ; Yang Hee HAN ; Sa Young SHIN ; Jae Hyuck JUN ; Yeong Min WOO ; Jung Ho YUN ; Gab Jin CHEON
The Korean Journal of Gastroenterology 2015;65(3):186-189
		                        		
		                        			
		                        			Esophageal and gastric varix, portal hypertensive gastropathy, Mallory-Weiss tear and gastric ulcer are common causes of bleeding in patients with liver cirrhosis. However, spontaneous arterial bleeding without a history of trauma is a rare cause of bleeding which can be fatal. We report a case of a 55-year-old woman with alcoholic liver cirrhosis who developed spontaneous bleeding of multiple right lumbar arteries and died in spite of repetitive transfusion and embolization.
		                        		
		                        		
		                        		
		                        			Arteries
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Gastrointestinal Hemorrhage/*etiology/therapy
		                        			;
		                        		
		                        			Hematoma/diagnosis
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Liver Cirrhosis/complications/*diagnosis
		                        			;
		                        		
		                        			Lung Injury/pathology
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Tomography, X-Ray Computed
		                        			
		                        		
		                        	
5.Laparoscopic diagnosis and treatment of rectum telangiectasia: report of a rare form of lower gastrointestinal hemorrhage.
Zhao-Cheng CHEN ; Hai-Jun DENG
Journal of Southern Medical University 2015;35(10):1508-1510
		                        		
		                        			
		                        			We report a case of rectum telangiectasia, a rare form of lower gastrointestinal hemorrhage caused by vascular malformation. The patient underwent laparoscopic assisted abdomino-perineal resection of the sigmoid colon-rectum telangiectasia. The extent and degree of pathological changes were observed directly from the intestinal wall during laparoscopic surgery, and after collection of biopsy evidence, concomitant definitive surgery was performed to achieve a minimally invasive effect.
		                        		
		                        		
		                        		
		                        			Gastrointestinal Hemorrhage
		                        			;
		                        		
		                        			diagnosis
		                        			;
		                        		
		                        			therapy
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Laparoscopy
		                        			;
		                        		
		                        			Rectum
		                        			;
		                        		
		                        			pathology
		                        			;
		                        		
		                        			Telangiectasis
		                        			;
		                        		
		                        			diagnosis
		                        			;
		                        		
		                        			therapy
		                        			
		                        		
		                        	
6.A method for bleeding detection in endoscopy images using SVM.
Wenming XU ; Guozheng YAN ; Zhiwu WANG ; Gang LIU ; Shuai KUANG ; Shaopeng ZHAO
Chinese Journal of Medical Instrumentation 2015;39(1):9-12
		                        		
		                        			
		                        			Because the huge number of images of the digestive tract by Wireless Capsule Endoscopy (WCE) are left to the medical personnels detected by their eyes, huge burden leaves to doctors. This article provides a classification of method based on SVM (Support Vector Machine) for the capsule endoscopy bleeding intelligent recognition. We created a new kind of feature parameter, and the experiment result can reach 83% specificity and 94% sensitivity.
		                        		
		                        		
		                        		
		                        			Capsule Endoscopy
		                        			;
		                        		
		                        			Gastrointestinal Tract
		                        			;
		                        		
		                        			pathology
		                        			;
		                        		
		                        			Hemorrhage
		                        			;
		                        		
		                        			diagnosis
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Sensitivity and Specificity
		                        			;
		                        		
		                        			Support Vector Machine
		                        			
		                        		
		                        	
7.Extramedullary relapse of multiple myeloma presenting as massive upper gastrointestinal bleeding: a rare complication.
Bulent YASAR ; Pembegul GUNES ; Ozgur GULER ; Selma YAGCI ; Dilek BENEK
The Korean Journal of Internal Medicine 2015;30(4):538-539
		                        		
		                        			
		                        			No abstract available.
		                        		
		                        		
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Antigens, CD38/analysis
		                        			;
		                        		
		                        			Biomarkers, Tumor/analysis
		                        			;
		                        		
		                        			Biopsy
		                        			;
		                        		
		                        			Gastrointestinal Hemorrhage/diagnosis/*etiology/therapy
		                        			;
		                        		
		                        			Gastroscopy
		                        			;
		                        		
		                        			Hematemesis/etiology
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Immunohistochemistry
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Melena/etiology
		                        			;
		                        		
		                        			Membrane Glycoproteins/analysis
		                        			;
		                        		
		                        			Multiple Myeloma/*complications/immunology/pathology/therapy
		                        			;
		                        		
		                        			Recurrence
		                        			;
		                        		
		                        			Stomach Neoplasms/*complications/immunology/pathology/therapy
		                        			
		                        		
		                        	
8.Successful Management of Recurrent Colon Ulcer in Hemodialysis Patient after Conversion to Peritoneal Dialysis.
Ji Young LEE ; In Tae MOON ; Hye Young LEE ; Hang Lak LEE ; Dong Soo HAN
The Korean Journal of Gastroenterology 2015;66(6):350-353
		                        		
		                        			
		                        			Lower gastrointestinal complications often develop in end stage renal disease patients, and among the more problematic is recurrent colon ulcer. The exact pathogenesis of this condition is not known and there were no specific therapeutic modalities concerning this type of disease entity. We report, with a literature review, a case of recurrent colon ulcer with intermittent hematochezia in an end stage renal disease patient on long term hemodialysis that improved after conversion to peritoneal dialysis.
		                        		
		                        		
		                        		
		                        			Aspirin/therapeutic use
		                        			;
		                        		
		                        			Colon/pathology
		                        			;
		                        		
		                        			Colonic Diseases/complications/*diagnosis/drug therapy
		                        			;
		                        		
		                        			Colonoscopy
		                        			;
		                        		
		                        			Drug Therapy, Combination
		                        			;
		                        		
		                        			Gastrointestinal Hemorrhage
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Kidney Failure, Chronic/*complications
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Peritoneal Dialysis
		                        			;
		                        		
		                        			Recurrence
		                        			;
		                        		
		                        			Ticlopidine/therapeutic use
		                        			;
		                        		
		                        			Ulcer/complications/*diagnosis/drug therapy
		                        			
		                        		
		                        	
10.Massive Upper Gastrointestinal Bleeding from Multiple Gastrointestinal Stromal Tumor in a Neurofibromatosis Patient.
The Korean Journal of Gastroenterology 2014;64(5):307-310
		                        		
		                        			
		                        			No abstract available.
		                        		
		                        		
		                        		
		                        			Endoscopy, Digestive System
		                        			;
		                        		
		                        			Gastrointestinal Hemorrhage/*etiology
		                        			;
		                        		
		                        			Gastrointestinal Stromal Tumors/complications/*diagnosis/radionuclide imaging
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Jejunum/pathology
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Neurofibromatosis 1/complications/*diagnosis/pathology
		                        			;
		                        		
		                        			Proto-Oncogene Proteins c-kit/metabolism
		                        			;
		                        		
		                        			Tomography, X-Ray Computed
		                        			
		                        		
		                        	
            
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