This article presents the research design and principal findings of the recent study " Structural basis for FGF hormone signalling" published in Nature. It highlights the study′s significance in elucidating the molecular mechanisms of fibroblast growth factor(FGF)23, FGF receptor(FGFR), Klotho, and heparan sulfate(HS) quaternary complex signalling. These findings offer crucial structural insights that could advance drug discovery for metabolic disorders like diabetes and chronic kidney disease.

Sports-related traumatic brain injury (srTBI) is a traumatic brain injury (TBI) caused by sports, which can result in cognitive and motor dysfunction. Currently, research on the molecular mechanism of srTBI and related drug development mainly relies on monolayer culture models and animal models. However, many differences exist in cell populations and inflammatory responses between these models and human pathophysiological processes. Most of the researches derived from the models can't effectively conducted translational research. Emerging three-dimensional (3D)
Animals ; Brain Injuries ; Brain Injuries, Traumatic ; Humans