1.Investigation and Analysis of HPV Positivity Among Adult Women in High-altitude Regions of Xizang: A Single-center Cross-sectional Study
Jinba YIXI ; Gaoxue WANG ; Ciren BASANG ; Zhuoga GASONG ; Zhi PU ; Yangjin CIREN ; Zhen BIAN ; Zhijuan LIU ; Juan DU
Medical Journal of Peking Union Medical College Hospital 2025;16(5):1325-1331
To investigate the detection status of human papillomavirus (HPV) among adult women in high-altitude regions of Xizang. A retrospective analysis was conducted on HPV genotyping results from outpatient, inpatient, and healthy adult female populations at Xizang Autonomous Region People's Hospital between March 2019 and July 2023. HPV positivity rates were compared across different ethnic groups and age strata, and temporal trends in HPV detection were analyzed. A total of 6498 adult women with HPV testing were included, with a mean age of (39.5±9.8) years, including 5440 Tibetan and 1058 Han women. The overall HPV positivity rate was 19.58%(1272/6498), predominantly single-type infections (14.99%), while double (3.71%) and triple-or-more infections (0.88%) were less common. Han women had a significantly higher HPV positivity rate than Tibetan women [29.30%(310/1058) The HPV positivity rate among adult women in high-altitude Xizang is relatively high, with significant differences in age-specific prevalence and dominant genotypes between Tibetan and Han women. Targeted measures, including HPV vaccination for young women and enhanced screening and treatment for both young and postmenopausal women, should be prioritized in this region.
2.Application study of test bolus and high-flow rate injection scheme in thyroid CT enhancement
Gaoxue LIN ; Yan ZHOU ; Jianwei WANG ; Jiliang CHEN ; Xiaoquan XU ; Lulu XU
Journal of Practical Radiology 2024;40(8):1349-1353
Objective To explore the application value of test bolus combined with a high-flow rate injection scheme in improving the quality of thyroid CT enhancement images.Methods A total of 126 patients who underwent thyroid plain scan and enhanced CT were selected.Among them,63 underwent conventional examination methods(control group),while the remaining 63 patients received test bolus and high-flow rate injection scheme(experimental group).Objective evaluation included the signal-to-noise ratio(SNR),contrast-to-noise ratio(CNR),thyroid enhancement rate,thyroid parenchyma-cancer difference,artifact index(AI)of the two groups of arterial phase images,thyroid enhancement rate of the two groups of venous phase images,and contrast agent dose of the two groups were all compared.Statistical analysis was performed via independent sample t-test or Mann-Whitney U test.Subjective evaluation included the evaluation of thyroid display in two groups of arterial phase images was conducted via the 4-point method,followed by the implementation of the Mann-Whitney U test.Results The SNR,CNR,thyroid enhancement rate,thyroid parenchyma-cancer difference,and AI in the arterial phase images of the experimental group were all significantly superior to those of the control group(P＜0.05).There was no statistically significant difference in the thyroid enhancement rate in the venous phase between control group and experimental group(P＞0.05);The contrast agent dose of the experimental group was significantly lower than that of the control group(P＜0.01).The thyroid display score observed in the arterial phase images of the experimental group was significantly higher than that of the control group(P＜0.01).Conclusion Using a test bolus combined with a high-flow rate injection scheme can significantly improve the image quality of thyroid CT enhancement.
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