Objective: To understand the prevalence of hyperuricemia in university students and examine associated factors,and to provide evidence for the prevention and treatment of hyperuricemia. Methods: Health examination data of 11 858 students for admission in October 2021 were used to compare the detection rates between groups with different characteristics. Multivariable Logistic regression was performed to identify potential factors associated with hyperuricemia. Results: A total of 3 372 cases of hyperuricemia were found, with a detection rate of 28.4%. The detection rate of male students was significantly higher than that of female students (42.4%,14.6%). The rate increased with higher BMI. Moreover, the detection rate was higher among undergraduates and those with hypertension( χ 2=1 126.2, 180.7, 138.2 ,107.9, P <0.01). Multivariable Logistic regression analysis showed that male sex, younger age, higher BMI, hypertension and higher hemoglobin level were positively associated with hyperuricemia, whereas higher glomerular filtration rate was negatively associated among the students( P <0.01). Conclusion Greater attention should be given to hyperuricemia in university students, and targeted health education should be strengthened for them, especially undergraduates, boys, overweight and obese students, and those with hypertension or high hemoglobin levels.