AIM: To study the protective effect and mechanism of Lycium barbarum polysaccharide (LBP) on diabetic kidney injury in rats. METHODS: Intraperitoneal injection of streptozotocin (STZ) to establish a rat model of diabetes (DM). The rats were divided into control group, diabetes group, LBP (60 mg/kg) group and LBP (30 mg/kg) group. The LBP group was given LBP by gavage once a day for 12 weeks. Determination of rat fasting blood glucose level, blood creatinine (Scr), urea nitrogen (BUN), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) content. Calculate relative kidney mass, observe changes in kidney tissue morphology, and determine superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activity, and glutathione (GSH) in kidney tissue, malondialdehyde (MDA) content, nuclear factor-кB (NF-кB) subunit p65, intercellular adhesion molecule-1 (ICAM-1) andmonocyte chemotactic protein-1 (MCP-1) expression. RESULTS: Compared with the control group, the blood glucose of rats in the diabetic group was significantly increased (≥16.7 mmol/L), the content of Scr, BUN, CRP, IL-6, and TNF-α in the serum increased, the content of MDA in the kidney tissue increased, and the content of GSH increased And GSH-Px, CAT, SOD activity decreased, NF-кB subunit p65, MCP-1 and ICAM-1 expression levels increased. Compared with the diabetes group, LBP can reduce blood glucose in diabetic rats, reduce the serum levels of Scr, BUN, CRP, IL-6, and TNF-α, reduce the content of MDA in kidney tissue, increase the content of GSH, GSH-Px, CAT, SOD, and down-regulate the expression levels of NF-кB subunit p65, MCP-1 and ICAM-1. CONCLUSION: LBP has a significant protective effect on diabetic kidney injury, and its mechanism of action may be related to the improvement of blood glucose, reduction of renal oxidative stress and reduction of inflammatory reaction in diabetic rats.

Objective To investigate the clinical efficacy and safety of hyperthermic intraperitoneal perfusion chemotherapy (HIPC) in treatment of advanced colorectal cancer.Methods The Meta-analysis was applied to analyze 8 randomized controlled quantitative studies published at domestic and abroad.These patients treated by HIPC after radical operation with colorectal cancer were included for the treatment group,and those treated only by radical operation with colorectal cancer for the control group.Relative risk (RR) of outcome variable of 3-year and 5-year survival rate and safety between the two groups were compared.Results There were 8 selected literatures,including 1 501 cases,in which 765 cases for treatment group,and 736 cases for control group.RR of 5-year survival rate of the total patients was 2.39 (95% CI:1.66-3.45).RR of 3-year survival rate of the total patients was 2.13 (95% CI:1.45-3.13).The results demonstrated that HIPC could improve 5-year and 3-year survival rate,and sensitivity analysis confirmed the conclusions more reliable.The security was described in 5 literatures,the available information showed smaller potential security issue.Conclusions HIPC after radical operation of advanced colorectal cancer can increase 5-year and 3-year survival rate of patients,improve the prognosis of patients.Whether patients with increased incidence of postoperative complications related to the HIPC is no clear-cut conclusions for lack of related research.

OBJECTIVETo summarize the therapeutic experience in removing huge craniofacial hemangioma in 135 cases and reveal the rules of repairing the damaged tissues or organs caused by the extirpation.

METHODSThe procedure was to remove the focal lesion correctly, control hemorrhage, keep the stable blood volume, repair and rebuild the damaged tissues or organs reasonably.

RESULTSThe focal lesion was removed rather completely without accidental injuries or deaths. The damaged tissues or organs were repaired and rebuilt quite satisfactorily.

CONCLUSIONHuge craniofacial hemangioma of any type should be operated on as early as possible with sufficient preoperative preparations.

Adult ; Facial Neoplasms ; surgery ; Female ; Hemangioma ; surgery ; Humans ; Male