Objective To investigate the clinical efficacy of sodium tanshinone ⅡA sulfonate(STS)combined with nicorandil in the treatment of coronary heart disease(CHD)patients with stable angina pectoris,and explore the influence on oxidative stress,serum myoglobin(Myo)and cardiac troponin T(cTnT)levels.Methods A total of 164 CHD patients with stable angina pectoris ad-mitted in our hospital from March 2022 to March 2024 were recruited and randomly divided into control group(82 cases,nicorandil treatment)and observation group(82 cases,STS combined with nicorandil treatment).The efficacy,oxidative stress indicators[superoxide dismutase(SOD),lipid peroxide(LPO),malondialdehyde(MDA),glutathione peroxidase(GSH-Px)],serum Myo and cTnT levels,cardiac function indicators[cardiac output(CO),left ventricular ejection fraction(LVEF)],angina pectoris symptoms,quality of life and exercise tolerance were compared before and after treatment and between the two groups,and adverse reactions were recorded.Results The total effective rate was significantly higher in observation group than the control group(95.12％vs 82.93％,P＜0.05).After treatment,the observation group obtained significantly higher SOD and GSH-Px levels,while lower LPO and MDA levels and serum Myo and cTnT lev-els when compared with the control group(P＜0.01).Obviously higher CO(5.74±0.59 L/min vs 5.38±0.46 L/min,P＜0.01)and LVEF[(55.06±4.27)％vs(49.14±3.85)％,P＜0.01]values in the observation group were observed after treatment than those in the control group.After treat-ment,the observation group had notably lower Canadian Cardiovascular Society angina pectoris grade and higher Seattle Angina Questionnaire score and increased results of 6-minute walking test when compared to the control group(P＜0.01).But there was no statistical difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion STS combined with nicorandil is helpful to improve the efficacy,reduces the oxidative stress,and protects the cardiac function in CHD patients with stable angina pectoris,and shows good safety at the same time.