Breast cancer metastases to the gastrointestinal tract are very rare occurrences. Among the histological subtypes of breast cancer, invasive lobular carcinomas have a high capacity of metastasis to uncommon sites including the stomach. Conversely, there has not been sufficient evidence supporting the gastric metastasis of invasive ductal carcinoma. Herein, we report a unique case of metastatic ductal breast carcinoma mimicking primary linitis plastica in a male patient, particularly focusing on the clinical and pathological features of presentation. Moreover, we propose a immunohistochemical panel of selected antibodies including those for cytokeratin 20, cytokeratin 7, estrogen receptor, progesterone receptor, E-cadherin, gross cystic disease fluid protein 15, and GATA binding protein 3 for an accurate differential diagnosis.
Antibodies ; Biomarkers ; Breast Neoplasms* ; Breast* ; Cadherins ; Carcinoma, Ductal ; Carcinoma, Lobular ; Carrier Proteins ; Diagnosis, Differential ; Estrogens ; Gastrointestinal Tract ; Humans ; Keratin-20 ; Keratin-7 ; Linitis Plastica* ; Male* ; Neoplasm Metastasis ; Receptors, Progesterone ; Stomach*