1.Bilateral Stress Fracture of Femur Neck, Fatigue Type of Non-Athlete Young Adult
Yeo Joon YUN ; Yong Jae NA ; Ji Won JUNG ; Kyu Hoon LEE
Clinical Pain 2019;18(2):126-129
		                        		
		                        			
		                        			Bilateral femoral neck stress fractures have been rarely reported. When diagnosed, they are usually limited to athletes or military personnel. A 35-year-old man, previously healthy, visited the emergency department for right inguinal pain. On physical examination, no external wound, tenderness or limitation of motion were found in either lower extremity. Plain radiography showed normal findings but an magnetic resonance image showed a linear fracture in the femoral neck. In this case, bilateral femoral neck stress fractures were found in a young non-athlete adult with no prior medical history of related injuries. Surgery is generally not performed for stress fractures but considering the patient's early mobilization and the need for quick reintegration into society, surgery was done in this case.
		                        		
		                        		
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Athletes
		                        			;
		                        		
		                        			Early Ambulation
		                        			;
		                        		
		                        			Emergency Service, Hospital
		                        			;
		                        		
		                        			Fatigue
		                        			;
		                        		
		                        			Femur Neck
		                        			;
		                        		
		                        			Femur
		                        			;
		                        		
		                        			Fractures, Stress
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Lower Extremity
		                        			;
		                        		
		                        			Military Personnel
		                        			;
		                        		
		                        			Physical Examination
		                        			;
		                        		
		                        			Radiography
		                        			;
		                        		
		                        			Wounds and Injuries
		                        			;
		                        		
		                        			Young Adult
		                        			
		                        		
		                        	
2.Serum myostatin levels are associated with abdominal aortic calcification in dialysis patients
Su Mi LEE ; Seong Eun KIM ; Ji Young LEE ; Hyo Jin JEONG ; Young Ki SON ; Won Suk AN
Kidney Research and Clinical Practice 2019;38(4):481-489
		                        		
		                        			
		                        			BACKGROUND: Serum myostatin levels are increased according to renal function decline and myostatin may be a main mediator of chronic kidney disease–related sarcopenia. A previous study reported that serum myostatin level was negatively associated with abdominal aortic calcification (AAC) in older males. The aim of this study was to assess the association between serum myostatin level and AAC among dialysis patients of both sexes. In addition, we analyzed the relationship between serum myostatin level, muscle mass, and bone mineral density (BMD).METHODS: In this cross-sectional study, we evaluated AAC in the lateral lumbar spine using plain radiography and BMD in 71 patients undergoing dialysis. We classified patients into two groups according to the median value of myostatin as follows: those with high myostatin levels (≥ 5.0 ng/mL) and those with low myostatin levels (< 5.0 ng/mL).RESULTS: The proportion of patients with an AAC score of five points or more was higher among those with low myostatin levels. Myostatin level was negatively associated with AAC scores on plain radiography and had a positive association with skeletal muscle mass and T-scores for BMD measured at the total hip and femur neck. Lower myostatin levels were independently associated with higher AAC scores following adjustment for age, sex, diabetes mellitus, dialysis vintage, dialysis modality, and osteoprotegerin level.CONCLUSION: Lower serum myostatin levels were associated with higher AAC scores, lower muscle mass, and lower BMD in dialysis patients. Further, prospective studies and those with larger cohorts are necessary to validate these findings.
		                        		
		                        		
		                        		
		                        			Bone Density
		                        			;
		                        		
		                        			Cohort Studies
		                        			;
		                        		
		                        			Cross-Sectional Studies
		                        			;
		                        		
		                        			Diabetes Mellitus
		                        			;
		                        		
		                        			Dialysis
		                        			;
		                        		
		                        			Femur Neck
		                        			;
		                        		
		                        			Hip
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Kidney
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Muscle, Skeletal
		                        			;
		                        		
		                        			Myostatin
		                        			;
		                        		
		                        			Osteoprotegerin
		                        			;
		                        		
		                        			Prospective Studies
		                        			;
		                        		
		                        			Radiography
		                        			;
		                        		
		                        			Sarcopenia
		                        			;
		                        		
		                        			Spine
		                        			;
		                        		
		                        			Vascular Calcification
		                        			
		                        		
		                        	
3.Determinants of Hip and Femoral Deformities in Children With Spastic Cerebral Palsy.
Yoona CHO ; Eun Sook PARK ; Han Kyul PARK ; Jae Eun PARK ; Dong wook RHA
Annals of Rehabilitation Medicine 2018;42(2):277-285
		                        		
		                        			
		                        			OBJECTIVE: To find factors affecting hip and femoral deformities in children with spastic cerebral palsy (CP) by comparing various clinical findings with imaging studies including plain radiography and computed tomography (CT) imaging. METHODS: Medical records of 709 children with spastic CP who underwent thorough baseline physical examination and functional assessment between 2 to 6 years old were retrospectively reviewed. Fifty-seven children (31 boys and 26 girls) who had both plain radiography of the hip and three-dimensional CT of the lower extremities at least 5 years after baseline examination were included in this study. RESULTS: The mean age at physical examination was 3.6 years (SD=1.6; range, 2–5.2 years) and the duration of follow-up imaging after baseline examination was 68.4 months (SD=22.0; range, 60–124 months). The migration percentage correlated with motor impairment and the severity of hip adductor spasticity (R1 angle of hip abduction with knee flexion). The femoral neck and shaft angle correlated with the ambulation ability and severity of hip adductor spasticity (R1 and R2 angles of hip abduction with both knee flexion and extension). CONCLUSION: Hip subluxation and coxa valga deformity correlated with both dynamic spasticity and shortening of hip adductor muscles. However, we found no correlation between femoral deformities such as femoral anteversion, coxa valga, and hip subluxation.
		                        		
		                        		
		                        		
		                        			Bone Anteversion
		                        			;
		                        		
		                        			Cerebral Palsy*
		                        			;
		                        		
		                        			Child*
		                        			;
		                        		
		                        			Congenital Abnormalities*
		                        			;
		                        		
		                        			Coxa Valga
		                        			;
		                        		
		                        			Femur Neck
		                        			;
		                        		
		                        			Follow-Up Studies
		                        			;
		                        		
		                        			Hip Dislocation
		                        			;
		                        		
		                        			Hip*
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Knee
		                        			;
		                        		
		                        			Lower Extremity
		                        			;
		                        		
		                        			Medical Records
		                        			;
		                        		
		                        			Muscle Spasticity*
		                        			;
		                        		
		                        			Muscles
		                        			;
		                        		
		                        			Physical Examination
		                        			;
		                        		
		                        			Radiography
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Walking
		                        			
		                        		
		                        	
4.Outcomes of Cephalomedullary Nailing in Basicervical Fracture.
Seok Hyun KWEON ; Sung Hyun LEE ; Seng Hwan KOOK ; Young Chae CHOI
Hip & Pelvis 2017;29(4):270-276
		                        		
		                        			
		                        			PURPOSE: A basicervical femoral fracture is defined as a fracture of base of neck of femur that occurs medially from intertrochanteric line above lesser trochanter. In this study, we intended to evaluate radiological and clinical results of basicervical femoral fractures treated by intramedullary nailing. MATERIALS AND METHODS: Fifteen patients, who underwent intramedullary nailing among 50 patients, out of 50 who were diagnosed with basicervical femoral fractures from July 2012 to May 2015 were studied. All of 15 patients' fracture were two-part basicervical fractures. Using radiography, we characterized the: i) state of reduction, ii) location of the lag screw, iii) tip apex distance (TAD), and iv) sliding distance of lag screw and bone union. Additionally, we performed clinical assessment before injury and at final follow-up. RESULTS: In radiological assessment, we achieved acceptable reduction state in all patients. All lag screws were fixated on appropriate locations. Mean TAD was 17.3 mm (11.0–21.1 mm), which showed insertion point of < 25 mm in all cases. The mean sliding distance of the lag screw was 5.1 mm (0.1–16.0 mm) at the final follow-up. The mean bone union period was 4.8 months (3–10 months) with achieving in all cases. In clinical assessment, Harris hip score, visual analogue scale score and Western Ontario and McMaster Universities Arthritis Index score, all of them significantly improved postoperatively compared with preoperative scores (P < 0.05). CONCLUSION: In elderly patients with basicervical femoral fractures, treatment with intramedullary nailing showed satisfactory results, considered to be a useful method if performed with skilled technique.
		                        		
		                        		
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Arthritis
		                        			;
		                        		
		                        			Femoral Fractures
		                        			;
		                        		
		                        			Femur
		                        			;
		                        		
		                        			Follow-Up Studies
		                        			;
		                        		
		                        			Fracture Fixation, Intramedullary
		                        			;
		                        		
		                        			Hip
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Methods
		                        			;
		                        		
		                        			Neck
		                        			;
		                        		
		                        			Ontario
		                        			;
		                        		
		                        			Radiography
		                        			
		                        		
		                        	
5.Multiple Fractures in Patient with Graves' Disease Accompanied by Isolated Hypogonadotropic Hypogonadism.
Hyon Seung YI ; Ji Min KIM ; Sang Hyeon JU ; Younghak LEE ; Hyun Jin KIM ; Koon Soon KIM
Journal of Bone Metabolism 2016;23(1):40-44
		                        		
		                        			
		                        			Isolated hypogonadotropic hypogonadism (IHH) is known to decrease bone mineral density due to deficiency of sex steroid hormone. Graves' disease is also an important cause of secondary osteoporosis. However, IHH does not preclude the development of primary hyperthyroidism caused by Graves' disease, leading to more severe osteoporosis rapidly. Here, we describe the first case of 35-year-old Asian female patient with IHH accompanied by Graves' disease and osteoporosis-induced multiple fractures. Endocrine laboratory findings revealed preserved anterior pituitary functions except for secretion of gonadotropins and showed primary hyperthyroidism with positive autoantibodies. Sella magnetic resonance imaging showed slightly small sized pituitary gland without mass lesion. Dual energy X-ray absorptiometry revealed severe osteoporosis in lumbar spine and femur neck of the patient. Plain film radiography of the pelvis and shoulder revealed a displaced and nondisplaced fracture, respectively. After surgical fixation with screws for the femoral fracture, the patient was treated with antithyroid medication, calcium, and vitamin D until now and has been recovering fairly well. We report a patient of IHH with Graves' disease and multiple fractures that is a first case in Korea.
		                        		
		                        		
		                        		
		                        			Absorptiometry, Photon
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Asian Continental Ancestry Group
		                        			;
		                        		
		                        			Autoantibodies
		                        			;
		                        		
		                        			Bone Density
		                        			;
		                        		
		                        			Calcium
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Femoral Fractures
		                        			;
		                        		
		                        			Femur Neck
		                        			;
		                        		
		                        			Gonadotropins
		                        			;
		                        		
		                        			Graves Disease*
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Hyperthyroidism
		                        			;
		                        		
		                        			Hypogonadism*
		                        			;
		                        		
		                        			Korea
		                        			;
		                        		
		                        			Magnetic Resonance Imaging
		                        			;
		                        		
		                        			Osteoporosis
		                        			;
		                        		
		                        			Pelvis
		                        			;
		                        		
		                        			Pituitary Gland
		                        			;
		                        		
		                        			Radiography
		                        			;
		                        		
		                        			Shoulder
		                        			;
		                        		
		                        			Spine
		                        			;
		                        		
		                        			Vitamin D
		                        			
		                        		
		                        	
7.Simultaneous Bilateral Fracture of Femoral Neck in Korea: A Case Report.
Jai Hyung PARK ; Hwa Jae JEONG ; Hun Kyu SHIN ; Eugene KIM ; Taeg Su KO ; Young Min CHOI
Hip & Pelvis 2015;27(1):53-56
		                        		
		                        			
		                        			Unilateral femoral neck factures are common and their incidence is increasing. However, simultaneous bilateral femoral neck fractures are rare. Although cases of simultaneous bilateral femoral neck fractures have been reported, most were caused by strong muscle contractions during electroconvulsive therapy. Simultaneous bilateral femoral neck fractures caused by a simple fall are an extremely rare injury; therefore, limited literature is available, and no case has been reported in Korea. We report herein a case of simultaneous bilateral femoral neck fractures caused by a simple fall. An 83-year-old woman visited the emergency department with bilateral hip joint pain and gait disturbance, which developed 1 day after a fall. Tenderness and severe limitation in left hip joint range of motion and mild limitation in right hip joint range of motion were observed on a physical examination. A Garden type IV femoral neck fracture in the left hip joint and a Garden type I femoral neck fracture in the right hip joint were observed on plain radiography. She underwent right screw fixation and left bipolar hemiarthroplasty 2 days after admission. The patient could walk using a walker 4 weeks postoperatively. Bone union in the right femoral neck was observed at the 3 month follow-up. No specific findings were observed at the left hip hemiarthroplasty site.
		                        		
		                        		
		                        		
		                        			Aged, 80 and over
		                        			;
		                        		
		                        			Electroconvulsive Therapy
		                        			;
		                        		
		                        			Emergency Service, Hospital
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Femoral Neck Fractures
		                        			;
		                        		
		                        			Femur Neck*
		                        			;
		                        		
		                        			Follow-Up Studies
		                        			;
		                        		
		                        			Gait
		                        			;
		                        		
		                        			Hemiarthroplasty
		                        			;
		                        		
		                        			Hip
		                        			;
		                        		
		                        			Hip Joint
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Incidence
		                        			;
		                        		
		                        			Korea
		                        			;
		                        		
		                        			Muscle Contraction
		                        			;
		                        		
		                        			Physical Examination
		                        			;
		                        		
		                        			Radiography
		                        			;
		                        		
		                        			Range of Motion, Articular
		                        			;
		                        		
		                        			Walkers
		                        			
		                        		
		                        	
8.Associations between Alpha Angle and Herniation Pit on MRI Revisited in 185 Asymptomatic Hip Joints.
Korean Journal of Radiology 2015;16(6):1319-1325
		                        		
		                        			
		                        			OBJECTIVE: To evaluate the association between alpha angle and herniation pit on MRI in asymptomatic hip joints and their associations with demographic variables. MATERIALS AND METHODS: Hip MRI of 185 asymptomatic hip joints of 105 adults (age 18 to 80 years) from September 2011 through December 2012 were retrospectively studied. Alpha angles were measured on oblique axial MR images by 2 observers. Herniation pit was determined by 1 observer. Size measures, prevalence, and statistical analyses were conducted regarding its association with age, gender, laterality (right or left hip). Intra- and inter-observer agreements were determined by intra-class correlation coefficient. RESULTS: The prevalence of herniation pit in asymptomatic hips was 21.6%. The range of alpha angle was 27.6-65.0 degrees. Seventeen and 16 out of 185 (9.1% and 8.6%) hip joints showed alpha angle of ≥ 55 degrees in first and second measurement sessions, respectively. There was no association between alpha angle ≥ 55 and presence of herniation pit. There was no association between alpha angle ≥ 55 and the size of herniation pit. Inter-observer agreement of alpha angle was 0.485 between first measurements of first vs. second observer, respectively. Intra-observer agreement of alpha angle was 0.654, respectively. Forty (21.6%) of 185 hip joints (35 of 105 patients, 33.3%) had herniation pit, with no difference according to age, gender, or laterality of hip joint. CONCLUSION: There is no association between alpha angle ≥ 55 degrees and presence of herniation pit or demographic variables.
		                        		
		                        		
		                        		
		                        			Adolescent
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Aged, 80 and over
		                        			;
		                        		
		                        			Asymptomatic Diseases
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Femur Neck/anatomy & histology/radiography
		                        			;
		                        		
		                        			Hip Joint/anatomy & histology/*radiography
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			*Magnetic Resonance Imaging
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Prevalence
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Young Adult
		                        			
		                        		
		                        	
9.New Reference Data on Bone Mineral Density and the Prevalence of Osteoporosis in Korean Adults Aged 50 Years or Older: The Korea National Health and Nutrition Examination Survey 2008-2010.
Kyung Shik LEE ; Su Hyun BAE ; Seung Hwa LEE ; Jungun LEE ; Dong Ryul LEE
Journal of Korean Medical Science 2014;29(11):1514-1522
		                        		
		                        			
		                        			This cross-sectional study was performed to investigate the reference values for bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) and the prevalence of osteoporosis in the Korean population by applying domestic reference data. In total, 25,043 Korean adults > or =20 yr of age (11,792 men and 13,251 women) participated in the study. The BMDs of the total hip, femoral neck, and lumbar spine were measured by DXA (Discovery-W, Hologic Inc.), and subjects with a BMD - 2.5 standard deviations or lower than the mean BMD for young adults (20-29 yr old) were considered to have osteoporosis. When applying the new reference values determined in this study from Korean subjects, the overall prevalence of osteoporosis increased in men aged > or =50 yr compared with that provided by the DXA manufacturer from Japanese subjects (12.2% vs. 7.8%, P<0.001) and decreased in postmenopausal women aged > or =50 yr (32.9% vs. 38.7%, P<0.001). According to the findings of this study, use of the reference values provided by the DXA manufacturer has resulted in the underdiagnosis of osteoporosis in Korean men and the overdiagnosis of osteoporosis in Korean women. Our data will serve as valuable reference standards for the diagnosis and management for osteoporosis in the Korean population.
		                        		
		                        		
		                        		
		                        			Absorptiometry, Photon
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Asian Continental Ancestry Group
		                        			;
		                        		
		                        			Bone Density
		                        			;
		                        		
		                        			Cross-Sectional Studies
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Femur Neck/radiography
		                        			;
		                        		
		                        			Hip/radiography
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Lumbar Vertebrae/radiography
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			*Nutrition Surveys
		                        			;
		                        		
		                        			Osteoporosis/*diagnosis/epidemiology
		                        			;
		                        		
		                        			Prevalence
		                        			;
		                        		
		                        			Reference Values
		                        			;
		                        		
		                        			Republic of Korea
		                        			
		                        		
		                        	
10.Presence of a Nail in the Medullary Canal; Is It Enough to Prevent Femoral Neck Shortening in Trochanteric Fracture?.
Hyung Keun SONG ; Han Kuk YOON ; Kyu Hyun YANG
Yonsei Medical Journal 2014;55(5):1400-1405
		                        		
		                        			
		                        			PURPOSE: Presence of a cephalomedullary nail (CMN) in the medullary canal has been thought as advantageous in the control of femoral neck shortening (FNS) and lag screw sliding in trochanteric fracture compared to extramedullary fixation system. However, researches on the factors that influence the degree of FNS after cephalomedullary nailing are lacking. MATERIALS AND METHODS: We observed 95 patients (mean age, 75+/-2.8 years) with trochanteric fractures who were treated with a CMN, and evaluated the relationship between FNS and patient factors including age, gender, fracture type (AO/OTA), bone mineral density, medullary canal diameter, canal occupancy ratio (COR=nail size/canal diameter), and tip-apex distance using initial, immediate postoperative, and follow-up radiography. RESULTS: Univariate regression analyses revealed that the degree of FNS was significantly correlated with fracture type (A1 versus A3, p<0.001), medullary canal diameter (p<0.001), and COR (p<0.001). Multiple regression analyses revealed that FNS was strongly correlated with fracture type (p<0.001) and COR (p<0.001). CONCLUSION: Presence of a CMN in the medullary canal could not effectively prevent FNS in patients with low COR and in A3 type fracture.
		                        		
		                        		
		                        		
		                        			Aged
		                        			;
		                        		
		                        			*Bone Nails
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Femur Neck/*radiography
		                        			;
		                        		
		                        			Hip Fractures/radiography/*surgery
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Orthopedic Procedures/*methods
		                        			;
		                        		
		                        			Regression Analysis
		                        			
		                        		
		                        	
            
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