1.MRI-based quantitative analysis of paraspinal muscle characteristics in patients with osteoporotic ver-tebral compression fractures
Zezheng CHEN ; Fangyong WANG ; Wenjie ZHANG
Chinese Journal of Spine and Spinal Cord 2024;34(6):595-601,619
Objectives:To compare and analyze the MRI characteristics and fatty infiltration(FI)of the lum-bar spine in patients with and without osteoporotic vertebral compression fracture(OVCF)to explore their rela-tionships with fracture.Methods:46 patients with OVCF(70.67±11.99 years old;11 males,35 famales)were retrospectively analyzed,and 46 age-(70.76±5.40)and sex-(11 males,35 famales)matched osteoporotic pa-tients without OVCF were taken as the control group.Paravertebral muscle FI,cross-sectional area(CSA),and vertebral bone quality(VBQ)score were measured on lumbar MRI.Independent samples t-test was used to compare the differences between the OVCF group and the control group,and regression analysis was per-formed to explore the risk factors for the development of OVCF.Results:Patients in the OVCF group had significantly higher VBQ scores(P<0.05)and significantly higher paravertebral muscle FI(P<0.05)than those in the control group.There was no significant difference in CSA of paravertebral muscles between the two groups.VBQ score(OR=1.963,P<0.01)and FI of paravertebral muscles represented by L4(OR=1.203,P<0.01)were the independent risk factors for OVCF.Conclusions:The MRI parameters of lumbar spine in patients with OVCF had greater VBQ scores and paravertebral muscle FI compared with the osteoporotic patients without OVCF;VBQ scores and paravertebral muscle FI are the independent risk factors for OVCF,and at-tentions should be paid to improve paravertebral muscle functions in the meantime of preventing OVCF.
2.Risk factors for calf muscle vein thromboses after spinal cord injury
Dejian ZHANG ; Shengfei LUO ; Mingliang YANG ; Degang YANG ; Fangyong WANG ; Jianjun LI
Chinese Journal of Physical Medicine and Rehabilitation 2021;43(4):342-346
Objective:To analyze the clinical data on hospitalized spinal cord injury patients with calf muscle vein thromboses (MCVTs) seeking prevention and treatment techniques.Methods:The medical records of 423 patients with spinal cord injury were collected. Those with MCVT constituted the observation group, while those without served as controls. Their clinical data were compared.Results:The risk factors for MCVT were screened in logistic regression analyses. The results showed that age, an ASIA grade of A or B, spinal fusion, preventive anticoagulation, physiotherapy treatment and a homocysteine level >15μmol/L were risk factors for the occurrence of a MCVT.Conclusions:Age, an ASIA grade of A or B, spinal fusion or an elevated serum homocysteine level are all risk factors for MCVT. Active anticoagulation and physical therapy may reduce the risk.
3. Recovery, rehabilitation and repair of spinal cord injury
Chinese Journal of Trauma 2019;35(12):1057-1059
Recovery, rehabilitation and repair of spinal cord injury are frequently mentioned in clinical practice, scientific research and teaching practice of spinal cord injury. The term of spinal cord injury rehabilitation is abused and relevant terms needs to be standardized. Based on the 《International Classification of Function, Disability and Health》(ICF), the following issues are discussed: spinal cord injury recovery and ICF impairment classification, spinal cord injury rehabilitation and ICF activity, participation classification, and the relationship between spinal cord injury recovery, rehabilitation and repair. The terms of spinal cord injury recovery, rehabilitation and repair are comprehensively analyzed to provide reference for clinical practice. Meanwhile, spinal cord injury researches are summarized and prospected.
4. Research progress in cell repair of spinal cord injury
Zhenrong ZHANG ; Fangyong WANG
Chinese Journal of Trauma 2019;35(12):1146-1152
The mechanism of cell transplantation in repairing spinal cord injury mainly include replacing damaged neurons, protecting host neurons, preventing apoptosis, promoting axon regeneration and synapse formation, promoting myelination and secreting nutritional factors to improve microenvironment. A variety of cells have been used to repair spinal cord injury in animal models with certain effects, but the repair effect on complete injury is not obvious. Due to the difficulty in repairing spinal cord injury and the complexity of high-quality clinical studies, there lacks safe and effective comprehensive treatment method to maximize the improvement and recovery of patients' motor function. In order to summarize the research progress of cell therapy in the treatment of spinal cord injury and promote the in-depth study in this field, this article reviews various cell repair methods for spinal cord injury in aspects of their current status, safety and effectiveness and discusses the prospects of cell repair of spinal cord injury.
5.Advance in Nutritional Problems and Intervention after Spinal Cord Injury (review)
Lihe ZHANG ; YI HONG ; Fangyong WANG
Chinese Journal of Rehabilitation Theory and Practice 2018;24(9):1039-1042
Changes in metabolism after spinal cord injury cause many nutritional problems, leading to an increased incidence of dyslipidemia, diabetes and cardiovascular diseases. Unreasonable diet structure will promote the occurrence of metabolic abnormalities, induce secondary lesions, and increase mortality in patients with spinal cord injury at early stage. A comprehensive intervention including exercise, diet and dietary supplements is needed .
6.Neuromodulation Therapy for Neurogenic Detrusor Overactivity after Spinal Cord Injury (review)
Qin ZHANG ; Yi HONG ; Fangyong WANG ; Shujia LIU
Chinese Journal of Rehabilitation Theory and Practice 2016;22(8):892-895
Neurogenic detrusor overactivity (NDO) often occurs after spinal cord injury, which often causes urinary tract infection, vesi-coureteral reflux, or even renal failure, and seriously impacts on the patient's quality of life. This paper reviewed the mechanism, the com-mon treatment methods, and neuromodulation theray of NDO after spinal cord injury, and elaborated percutaneous posterior tibial nerve stimulation, pudendal nerve regulation and the sacral neuromodulation respectively.
7.Spinal Cord Injury Rehabilitation Physician Training System:Comparation of Harvard University and Capital Medical University
Chinese Journal of Rehabilitation Theory and Practice 2016;22(3):365-367
Objective To compare the difference of the spinal cord injury rehabilitation physician training systems between Harvard Uni-versity and Capital Medical University. Methods The spinal cord injury rehabilitation physician training systems of Capital Medical Univer-sity and Harvard University were investigated, including the degree training time, residence training time, training fee and institution. Re-sults Degree education time was more in the basic science in Harvard University than in Capital Medical University. The residence training time was 7 years and 5 years for Harvard University and Capital Medical University, respectively, and the ratio of specialties and sub-spe-cialties was not significantly different. There was a total of 26 spinal cord injury community rehabilitation clinics in Harvard University sys-tem, and none in Capital Medical University. Conclusion Some light can be drawn from the spinal cord injury rehabilitation physician train-ing system of Harvard University, to improve the scholastic building of Capital Medical University.
8.Effect of Short-segment Pedicle Screws System with or without Pedicle Screws on Fractured Level on Type A Thoracic and Lumbar Spine Fracture
Fangyong WANG ; Jianjun LI ; Yi HONG
Chinese Journal of Rehabilitation Theory and Practice 2015;(11):1308-1310
Objective To investigate the effects of short-segment pedicle screws system on type A thoracic and lumbar spine fracture with or without pedicle screws on the fractured level. Methods 23 patients with type A thoracic and lumbar spine fracture were included, in which 11 cases received traditional short-segment pedicle screws system without pedicle screws on the fractured level (group A), and other 12 cases with pedicle screws on the fractured level (group B). The anterior vertebral height, posterior vertebral height and local kyphosis an-gle were measured before and after operation. Results All pedicle screws were successfully implanted with good location and stability. The vertebral height and kyphosis angle significantly improved after operation in both groups (P<0.05), and the improvement of kyphosis angle was more in group B than in group A (P<0.05). Conclusion Short-segment pedicle screws system with pedicle screws on the fractured level may fine correct the kyphosis angle in short term.
9.Analysis of the Factors Influencing Clinical Teaching Quality in Spinal Cord Injury Specialty
Chinese Journal of Rehabilitation Theory and Practice 2014;(8):798-800
Spinal cord injury rehabilitation is an important part of rehabilitation medicine. The clinical education of graduates in spinal cord injury specialty is complex and unique. The graduates' incorrect learning methods and poor academic basis are dominant factors that will influence the teaching quality. And the teachers' poor professional knowledge will lead to the failing of meeting the requirements of clinical teaching and will influence the teaching quality. The teachers should make individualized teaching plan based on the student's academic background, clinical basis and degree level. In clinical practice, the teaching departments should improve their hardware and software condition. The clinical teachers should try to improve their professional level and teaching skills by intensifying the self-education. The graduate students should make modification and innovation in learning methods according to their own problems.
10.Three Dimensional Analysis of Thoracolumbar Pedicle Anatomical Parameters
Chinese Journal of Rehabilitation Theory and Practice 2012;18(2):134-136
Objective To apply the three dimensional reconstruction thoracolumbar pedicle anatomical parameters in spine surgery pedicle screw implantation. Methods 6 healthy specimen spines were chosen and three dimensional spine reconstruction was based on 2 mm CT scan of the spines. The anatomical parameters including length and angle parameters were calculated based on the three dimensional reconstruction images. Results The pedicle width of T9~L4 was 4.68~8.70 mm, and increased gradually from T9 to L4. But the pedicles width of T12, L1 and L2 were smaller than the others. The pedicle height of T9~L4 was 8.19~12.76 mm. There was no significant difference from T9 to L4. The pedicle height of T12 was the biggest among them. The pedicle transverse angle was from 6.26 º to 13.06 º and increased gradually from T9 to L4. But for the pedicle sagittal angle, the difference is not obvious and most of them are in the range of ±5 º. Conclusion Three dimensional reconstruction and calculation of thoracolumbar pedicle can show the anatomical characteristics of the spine and provide evidence for individual pedicle screw implantation.


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