Nyoshinsan is one of the Kampo formulations for the treatment of hot flash or dizziness, which are typically seen in chi-no-michi syndrome (characterized by physical and/or mental symptoms related to female hormone variation). But nyoshinsan is less frequently prescribed than three major formulas in gynecological field including tokisyakuyakusan, kamishoyosan and keisibukuryogan. Furthermore, few case series study of nyoshinsan has been reported so far. To elucidate clinically useful indication sho of nyoshinsan, we retrospectively analyzed medical records of the patients prescribed nyoshinsan for past 5 years in our institute. In consequence, majority of patients prescribed nyoshinsan had both blood stasis and qi-abnormality including qi-deficiency, qi-stagnation and qi-counterflow due to physical or mental stresses. On the other hand, they rarely had signs of fluid retention. These findings may be useful for more effective clinical application of nyoshinsan.