Relationship between quality of life, depression and burden of mothers with child withсerebral palsy Background: Regular care and treatment of children diagnosed with cerebral palsy can be time-consuming and costly, increasing the risk of burden and depression, and adversely affecting quality of life. So there are many reasons why mothers' quality of life is poor socio-economic status and support related to the family, cerebral palsy from child care techniques and understanding of the disease the quality of life of mothers with sick children depends. There are few studies in Mongolia that assess the quality of life and other factors of mothers with cerebral palsy. We aimed assessing the relationship between quality of life, stress and depression in mothers with children with cerebral palsy. Materials and methods: The survey was conducted to the cross-sectional design of the analytical study based on the NCMCH. The study included 70 mothers with children with cerebral palsy. The survey data were collected using a general demographic questionnaire and three groups of questionnaires (WHOQOL-BREF, Stephen Zarit, Beck’s ). Quality of life and burden were measured as minimum <5, maximum 95 and minimum >20, maximum <88 respectively. Depression score measured as minimum >10, maximum <40. Results: The average quality of life of all mothers was 52.43 ± 11.95, environment was 44.8 ± 15.8. Maternal depression rates were 21 (30%), 90.0% of mothers had burden, and quality of life was statistically likely to be inversely related to depression and stress. Conclusion: The poor quality of life of mothers with children with cerebral palsy, high levels of depression and stress indicate the need for policies to reduce the quality of life.