The Korean Society of Infectious Diseases has been regularly developing guidelines for adult immunization since 2007. In 2023, the guidelines for the following seven vaccines were revised: influenza, herpes zoster, pneumococcal, tetanus-diphtheria-pertussis (Tdap), human papillomavirus (HPV), meningococcal, and rabies vaccines. For the influenza vaccine, a recommendation for enhanced vaccines for the elderly was added. For the herpes zoster vaccine, a recommendation for the recombinant zoster vaccine was added. For the pneumococcal vaccine, the current status of the 15-valent pneumococcal conjugate vaccine and 20-valent PCV was described. For the Tdap vaccine, the possibility of using Tdap instead of tetanus-diphtheria vaccine was described. For the HPV vaccine, the expansion of the eligible age for vaccination was described. For the meningococcal vaccine, a recommendation for the meningococcal B vaccine was added. For the rabies vaccine, the number of pre-exposure prophylaxis doses was changed. This manuscript documents the summary and rationale of the revisions for the seven vaccines. For the vaccines not mentioned in this manuscript, the recommendations in the 3rd edition of the Vaccinations for Adults textbook shall remain in effect.

Purpose: To evaluate the clinical outcomes of a new refractive corneal lenticule extraction method (SmartSight) using a Schwind ATOS femtosecond laser (Schwind Eye-Tech-Solutions, Kleinostheim, Germany). Methods: The medical records of 338 eyes of 170 patients who underwent SmartSight treatment from April to September 2022 and were followed-up for at least 3 months were retrospectively analyzed. The patients were followed-up at 1 day, 1 week, and 1 and 3 months after operation. Refraction, visual acuity, and intraocular pressure were measured at each visit. Results: Preoperatively, the uncorrected distant visual acuity was 1.26 ± 0.33 logarithm of minimum angle or resolution (logMAR) and the spherical equivalent was -4.52 ± 1.77 diopters. The 3-month, postoperative, uncorrected distant visual acuity was 0.01 ± 0.03 logMAR and the spherical equivalent was -0.12 ± 0.22 diopters. The 3-month data were as follows: efficacy of refractive surgery, 0.99 ± 0.11; safety, 1.00 ± 0.05; predictabilities at ±0.5 and ± 1.0 diopters, 97% and 100%, respectively. Conclusions Myopic astigmatism correction using the SmartSight method was effective, safe, and predictable in terms of visual outcomes.

Aspergillus tracheobronchitis (AT), an unusual form of invasive pulmonary aspergillosis (IPA), is characterized by pseudomembrane formation, ulcer or obstruction that is predominantly confined to tracheobronchial tree. Hematologic malignancies, neutropenia, solid organ transplantation, chronic corticosteroid therapy and acquired immunodeficiency syndrome (AIDS) are known to be major predisposing conditions. However, since the introduction of highly active antiretroviral therapy, there is only one reported case of AT in AIDS patient. After pandemic of influenza A/H1N1 2009, there are several reports of IPA in patient with influenza and most of them received corticosteroid or immunosuppressive therapy before the development of IPA. We present a 45 year-old AIDS patient with influenza A infection who developed pseudomembranous AT without corticosteroid use or immunosuppressive therapy.
Acquired Immunodeficiency Syndrome ; Antiretroviral Therapy, Highly Active ; Aspergillus* ; Bronchitis ; Coinfection* ; Hematologic Neoplasms ; Humans ; Influenza, Human* ; Invasive Pulmonary Aspergillosis ; Neutropenia* ; Organ Transplantation ; Pandemics ; Transplants ; Ulcer

A 60-year-old man with bilateral corneal opacity underwent cataract extraction surgery involving the use of a limbal relaxing incision in his left eye. He had lower lid ectropion and lagophthalmos in both eyes. Eleven days after the surgery, a slit-lamp examination revealed a neurotrophic corneal ulcer with a punch-out epithelial defect and rolled edges at the center of the pre-existing corneal opacity. The patient was treated with sodium hyaluronate, autologous serum, and oral doxycycline. Six weeks after the surgery an improvement in corneal sensation was observed and the neurotrophic corneal ulcer subsequently healed over the course of one year. In this report, we present a case of neurotrophic keratitis that occurred after performing cataract surgery concurrent with a limbal relaxing incision. As such, we suggest that limbal relaxing incisions should be performed cautiously in patients with causative risk factors for corneal hypesthesia.
Cataract Extraction/*adverse effects/*methods ; Corneal Diseases/etiology ; Corneal Ulcer/*etiology/*pathology/physiopathology ; Humans ; Hypesthesia/etiology ; Limbus Corneae/*surgery ; Male ; Middle Aged ; Ophthalmologic Surgical Procedures/*adverse effects ; Phacoemulsification ; Wound Healing

PURPOSE: Stress urinary incontinence (SUI) commonly occurs in women, and it causes enormous impact on quality of life. Surgery, drugs, and exercise have been recommended for the treatment of this disease. Among these exercise is also known to be effective for relieving thesymptoms of SUI, however, the efficacy and underlying mechanisms of exercise on SUI are poorly understood. In the present study, we investigated the effect of treadmill exercise on abdominal leak-point pressure and neuronal activity in the medial preoptic nucleus (MPA), ventrolateral periaqueductal gray (vlPAG), and pontine micturition center (PMC) following urethrolysis in rats. MATERIALS AND METHODS: Adult female Sprague-Dawley rats, weighing 250+/-10 g (9 weeks old), were used in this study. After having undergone transabdominal urethrolysis to induce SUI, the rats were divided into three groups (n=6 in each group): a sham operation group, an SUI-induced group, and an SUI-induced and treadmill exercise group. The rats in the exercise group performed treadmill running for 30 min once a day starting 2 weeks after the induction of SUI and continuing for 4 weeks after surgery. For this study, determination of abdominal leak point pressure and immunohistochemistry for c-Fos in the brain were performed. RESULTS: Induction of transabdominal urethrolysis significantly reduced the abdominal leak point pressure, thereby contributing to the induction of SUI. In contrast, abdominal leak point pressure was significantly improved by treadmill exercise. The expression of c-Fosin the MPA, vlPAG, and PMC, the brain areas relating to micturition, was enhanced by the induction of SUI, whereas treadmill exercise significantly suppressed SUI-induced c-Fos expression, suggesting that neuronal activation in the micturition centers was suppressed by treadmill exercise. CONCLUSION: The present results suggest that treadmill exercise may be an effective therapeutic modality for ameliorating the symptoms of SUI.
Adult ; Animals ; Brain ; Exercise Test ; Female ; Humans ; Immunohistochemistry ; Neurons ; Periaqueductal Gray ; Quality of Life ; Rats ; Rats, Sprague-Dawley ; Running ; Salicylamides ; Urinary Incontinence ; Urination

PURPOSE: To identify the impact of the presence of peripheral anterior synechia (PAS) on the depth of the anterior segment in patients with a shallow anterior chamber after laser iridotomy (LI) by analyzing changes in the anterior segment biometry using ultrasound biomicroscopy (UBM). METHODS: Twenty eyes of 20 patients with PAS and shallow anterior chamber, and another 20 eyes of 20 patients with shallow anterior chamber without PAS were studied. The changes in the anterior segment biometry for each group of patients were examined using gonioscopy and UBM before and after the LI. RESULTS: The central corneal thicknesses and scleral thicknesses of the two groups did not show significant differences (p > 0.05). The anterior chamber depths, anterior chamber angles, trabecular meshwork-iris distances, and angle-opening distances 500 increased significantly after the peripheral LI (p < 0.05) in both groups. However, the difference in the increases in the anterior segment biometries between the two groups was not statistically significant. CONCLUSIONS: LI can increase the depth of the anterior chamber regardless of the presence of PAS.
Anterior Chamber ; Biometry ; Eye ; Gonioscopy ; Humans ; Microscopy, Acoustic

PURPOSE: To present a case of acute angle-closure glaucoma in a nanophthalmos patient. CASE SUMMARY: A 28-year-old woman visited the hospital for a sudden pain in the left eye, she had a small orbital bone and narrow palpebral fissurea in both eyes. Her intraocular pressure (IOP) was 58 mmHg in the left eye. The slit lamp examination showed shallow anterior chambers in both eyes, and the gonioscopic examination showed a closed angle in the left eye. The diameters of the corneas were 11 mm , and the axial lengths were 19.7 mm in the right eye and 19.6 mm in the left eye. The depths of the anterior chambers were 1.51 mm in the right eye and 1.82 mm in the left eye. The disease was diagnosed as acute angle-closure glaucoma in the left eye of the patient with nanophthalmos, and thus the IOP of the left eye was lowered using ophthalmic drugs and medications. Laser iridotomy was performed on both eyes. CONCLUSIONS: For around a year of follow-up after laser iridotomy, complications such as the rise of intraocular pressure and choroidal effusion were not observed. This suggests that laser iridotomy can be an effective treatment for acute angle-closure glaucoma accompanying nanophthalmos.
Adult ; Anterior Chamber ; Choroid ; Cornea ; Eye ; Female ; Follow-Up Studies ; Glaucoma, Angle-Closure ; Humans ; Intraocular Pressure ; Orbit

PURPOSE: To report a case of nasal-type NK/T cell lymphoma occurring in the sphenoid and ethmoid sinuses of an orbital apex syndrome patient. CASE SUMMARY: A 61-year-old male patient visited our hospital for the impairment of vision in the right eye for the previous month, and for right-side blepharoptosis, pain around the eyeball, and limitation of extraocular movement in the right eye for three days earlier. In MRI (magnetic resonance image) and CT (computed tomography), shades with vague boundaries were observed in the right sphenoid and ethmoid sinuses, and open biopsy and decompression were performed for the lesions. After the surgery, the vision of the right eye increased, and improvement was observed in the right blepharoptosis, the pain around the eyeball, and in the limitation of motility of the extraocular muscle in the right eye. The patient was diagnosed with nasal type NK/T cell lymphoma in biopsy, and radiotherapy and chemotherapy were performed.
Biopsy ; Blepharoptosis ; Decompression ; Ethmoid Sinus ; Eye ; Humans ; Lymphoma ; Male ; Middle Aged ; Muscles ; Orbit ; Vision, Ocular

PURPOSE: The aim of the present study was to ascertain whether the increase of carotid intima- media thickeness (cIMT) as one of premature pathologic changes of atherosclerosis, was present in obese children compared to normal weight children. METHODS: The obese group consisted of 21 obese/overweight (body mass index (BMI) above 85 percentile of age, sex standards) children and the control group of 11 normal weight children. None of the children had any chronic illnesses or previous medication history. We investigated the age, sex, height, weight, and systolic/diastolic blood pressure. We measured cIMT by ultrasonogram. In 19 of the obese group, we tested the serum glucose level, liver transaminase level, and cholesterol level etc. RESULTS: The increase of cIMT in obese group did not achieved statistical significance (obese group vs. control group; 0.42 vs. 0.40 mm, P=0.0592). In addition, cIMT showed no significant correlation with any physical/laboratory variables including BMI (P=0.0585). CONCLUSION: To our knowledge, this is the first study to measure the cIMT in Korean children. Though the results approached statistical significance, we could not prove an increase of cIMT in obese children or an association between cIMT and BMI, due to the study's small sample size. In the future, larger and more extensive trials are needed.
Atherosclerosis ; Blood Glucose ; Blood Pressure ; Carotid Intima-Media Thickness* ; Child* ; Cholesterol ; Chronic Disease ; Humans ; Liver ; Obesity ; Sample Size ; Ultrasonography

STUDY DESIGN: Surgical simulation using CT images of the cervical spine and computers. OBJECTIVES: The optimal trajectories for C1 lateral mass screws and C2 pars-pedicle screws were sought, and their accuracy evaluated. LITERATURE REVIEW SUMMARY: There have been a few suggestions for the trajectories of the screws listed above, but these are somewhat vague or impractical. MATERIALS AND METHODS: Using 1 mm-sliced CT scan images of 128 patients, and a V-works spine surgery simulator 4.0 (Cybermed, Inc., Korea), the optimal trajectories with which 4.0 mm screws can be inserted without breaching bone cortices were determined. The anatomical characteristics of the cases having a cortical perforation were analyzed. RESULTS: The insertion point suggested for a C1 screw was 1 mm lateral to the middle of the junction of the posterior arch and posterior inferior part of the lateral mass. The screw was directed 15 degrees medially and toward the junction of the superior 2/3 and inferior 1/3 of the anterior tubercle in the lateral fluoroscopic view. The C2 screw was directed 30 degrees medially, and toward the anterior end of the superior articular process, in the lateral fluoroscopic view. The insertion point was one where the screw was inserted close to the superomedial border of the pedicle. Using these trajectories, all (256/256) of the C1 screws were inserted safely. However, 6.3% (16/256) of the C2 screws breached the inferolateral cortices of the pedicles, due to the pedicles being either too narrow or too medially angulated. CONCLUSIONS: Herein, more practical and safe screw trajectories have been suggested. Using these trajectories, all the C1 and most of the C2 screws were able to be inserted safely. However, there were some cases in which the C2 screws could not be inserted without breaching the vertebral artery groove. Therefore, preoperative thin-slice CT scanning, with three-dimensional reconstruction and/or three-dimensional CT-angiography, is recommended for these cases.
Computer Simulation ; Humans ; Spine ; Tomography, X-Ray Computed ; Vertebral Artery