Objective: To analyze the trend change of the drowning mortality among children and adolescents in Chongqing, 2012-2021, and to provide suggestion for drowning prevention and control. Methods: Drowning death cases (ICD-10:W65.0-W74.9) among children and adolescents in Chongqing from 2012 to 2021 were derived from Chongqing death registration system. The difference of the drowning mortality between male and female, urban and rural area were compared by Chi square test. The trend change of the drowning mortality between 2012 and 2021 was analyzed by annual percent change( APC ). Results: The mortality and ASMR of drowning among children and adolescents decreased from 9.57/10 5, 9.42/10 5 in 2012 to 2.80/10 5, 2.83/10 5 in 2021 significantly( t=10.93, 10.52, P <0.01). And its APC were -13.15% and 13.06% respectively. The drowning mortality in male was higher than that in female( P <0.05). The drowning mortality in rural area was higher than that in urban area( P <0.05). The mortality of drowning among children aged between 0 and 4 years old, 5 and 9 years old, 10 and 14 years old decreased by 15.30 %,17.80% and 11.40%( APC =-15.30%, -17.80%, -11.40%, t=11.11, 9.22, 5.62, P <0.05). The proportion of drowning in natural water field among children and adolescents accounted for about 80%. Conclusion The mortality of drowning among children and adolescents in Chongqing decreases rapidly. Vulnerable population of drowning includes boys, rural children and adolescents, and children age of 0-14 years old. Comprehensive prevention for drowning should be carried out continuously.

Objective To analyze the epidemiological characteristic of stroke incidence and mortality in Chongqing, and to provide suggestions for targeted prevention and control of stroke. Methods Data of reported cases of ischemic stroke (I63), hemorrhagic stroke (I61-I62), subarachnoid hemorrhage (I60), and unclassified stroke (I64) in Chongqing in 2018 was collected. SPSS 25.0 was used to calculate the incidence, age-standardized incidence rate (ASIR), mortality, age-standardized mortality rate (ASMR) and proportion of stroke. The incidence and mortality of stroke were compared by Chi-square test between males and females, and between central urban areas and suburban counties. Results In 2018, the incidence and ASIR of stroke were 294.61/105 and 222.43/105 in Chongqing, respectively. The mortality and ASMR of stroke were 116.34/105 and 85.81/105. The incidence, ASIR and proportion of ischemic stroke were 186.63/105, 139.17/105 and 63.35%, respectively. The incidence of ischemic stroke in male was higher than that in female (χ²=18.52, P<0.001). The incidence of ischemic stroke in central urban areas was higher than that in suburban counties (χ²=29.50, P<0.001). The mortality of ischemic stroke in male was higher than that in female (χ²=6.67, P=0.010). The mortality of ischemic stroke in suburban counties was higher than that in central urban areas (χ²=17.55, P<0.001). The incidence, ASIR and proportion of hemorrhagic stroke were 78.15/105, 60.44/105 and 26.53%, respectively. The incidence of hemorrhagic stroke in male was higher than that in female (χ²=27.64, P<0.001). The incidence of hemorrhagic stroke in suburban counties was higher than that in central urban areas (χ²=18.60, P<0.001). The mortality of hemorrhagic stroke was the highest among all subtypes of strokes. The mortality, ASMR and proportion of hemorrhagic stroke was 64.44/105, 48.28/105 and 55.39%, respectively. The mortality of hemorrhage stroke in male was higher than that in female (χ²=23.46, P<0.001). The mortality of hemorrhage stroke in suburban counties was higher than that in central urban areas (χ²= 43.57, P<0.001). Conclusion The incidence and mortality of stroke in Chongqing were lower than the national average levels. The incidence of ischemic stroke was higher than that of hemorrhage stroke. The mortality of hemorrhage stroke was higher than that of ischemic stroke. Men and suburban counties were the focus of stroke prevention and control in Chongqing.

Objective To analyze the trend of the mortality and disease burden of drowning in Chongqing and provide suggestions for drowning prevention and control. Methods The information data on drowning deaths in Chongqing (ICD-10 code: W65-W74) from 2012 to 2018 were collected. SPSS 25.0 software was used to calculate and analyze indicators such as mortality, age standardized mortality rate by Chinese population (ASMRC), years of life lost with premature death (YLL_s), years lived with disability (YLD_s), and disability adjusted life years (DALY_s). The differences of drowning mortality between male and female, urban and rural areas were tested by Chi-square test. The trend of drowning mortality and disease burden was calculated as annual percent change (APC) using curve-estimation model of logistic regression. The difference of APC was tested by t-test (α=0.05). Results The mortality and ASMRC of drowning decreased from 4.90/100 000 and 4.87/100 000 in 2012 to 3.85/100 000 and 3.59/100 000 in 2018, respectively. The APCs were -3.34% and -4.49%, respectively. There was no significant difference in the change trend (t value: 2.34 and 2.42, P>0.05). The mortality of drowning in the male was higher than that in the female (P<0.05). The mortality of drowning in rural area was higher than that in urban area (P<0.05). The mortality of drowning among children under 5 years old was the highest. The mortality of drowning among children under 5 years old decreased from 14.47/100 000 in 2012 to 4.28/100 000 in 2018, and the APC was -17.06%. The change trend was statistically significant (t=8.86, P<0.001). The drowning mortality rate in the 65-year-old and older group increased from 8.14/100 000 in 2012 to 9.77/100 000 in 2018, with an APC of 4.92%. There was no significant difference in the trend of change (t=2.56, P=0.051). The rates of DALYs and YLLs decreased from 2.73 thousand person-years and 2.70 thousand person-years in 2012 to 1.66 thousand person-years and 1.64 thousand person-years in 2018, respectively. The APCs were -7.41% and -7.41%, respectively. All of these were statistically significant (P<0.05). The rate of YLDs decreased from 0.03 thousand person-years in 2012 to 0.02 thousand person-years in 2018. There was no significant difference in the trend of change (P>0.05). Conclusion The mortality and disease burden of drowning in Chongqing showed a decreasing trend, which was lower than the national average level. Children, male and elderly people are the vulnerable population to prevent drowning, and rural areas are the key areas to prevent drowning.

Objective To investigate the associations between expression of Tensin1 protein and clinicpathological characteristics and prognoses of gastric cancer (GC) patients.Methods The retrospective casecontrol study was conducted.The clinicopathological data of 163 GC patients who were admitted to the Affiliated Hospital of Jiangsu University between July 31,2011 and December 31,2013 were collected.The GC tissues and adjacent normal tissues were taken to paraffin imbedding,and then were detected by immunohistochemistry.Observation indicator:(1) expressions of Tensinl protein in GC tissues and adjacent normal tissues;(2) association between expression of Tensinl protein in GC tissues and clinicopathological characteristics;(3) followup and survival situations;(4) prognostic factors analysis.Follow-up using telephone interview was performed to detect survival up to January 1,2017.Measurement data with skewed distribution were described as M (range).Count data were analyzed using the chi-square test or pairing chi-square test.The survival curve and rate were respectively drawn and calculated using the Kaplan-Meier method,and Log-rank test was used for survival analysis.The univariate analysis and multivariate analysis were done using the COX roportional hazard model.Results (1) Expressions of Tensinl protein in GC tissues and adjacent normal tissues:immunohistochemistry showed that Tensinl protein in GC tissues and adjacent normal tissues mainly expressed in cytoplasm.Of 163 patients,154 (66 with high expression and 88 with low expression) and 9 had respectively positive and negative expressions of Tensinl protein in GC tissues;79 (37 with high expression and 42 with low expression) and 84 had respectively positive and negative expressions of Tensinl protein in adjacent normal tissues,with statistically significant differences in positive expression ratio and expression levels (x2=64.65,12.93,P＜0.05).(2) Association between expression of Tensinl protein in GC tissues and clinicopathological characteristics:high expression rate of Tensinl protein in GC tissues were respectively 31.34％ (21/67) in GC patients with tumor metastases and 46.88％ (45/96) in GC patients without tumor metastasis,with a statistically significant difference (x2 =3.95,P＜0.05).(3) Follow-up and survival situations:all the 163 patients were followed up for 3.3-64.7 months,with a median time of 28.7 months.The 3-year cumulative disease-free survival rate and cumulative overall survival rate in GC tissues were 63.12％,74.22％ in 66 patients with high expression of Tensinl protein and 47.30％,55.74％ in 97 patients with low and negative expressions of Tensin1 protein,showing statistically significant differences in above indicators (x2 =4.58,4.11,P＜0.05).Survival analysis of subgroups showed that 3-year cumulative disease-free survival rate in GC tissues of patients with maximum tumor dimension ≥ 5 cm,nerve and / or vascular invasions and stage Ⅲ of TNM staging were 45.98％,62.79％,52.75％ in patients with high expression of Tensin1 protein and 18.11％,31.10％,32.80％ in patients with low and negative expressions of Tensin1 protein,with a statistically significant difference (x2 =5.85,7.89,4.96,P＜0.05).The 3-year cumulative overall survival rate was respectively 66.00％,75.75％,67.93％ in patients with high expression of Tensin1 protein and 30.74％,40.15％,44.67％ in patients with low and negative expressions of Tensinl protein,with statistically significant differences (x2 =7.59,9.62,4.32,P ＜ 0.05).(4) Prognostic factors analysis:results of univariate analysis showed that maximum tumor dimension,histological grade,nerve and / or vascular invasions,postoperative TNM staging,postoperative adjuvant chemotherapy and expression of Tensin1 protein were related factors affecting prognoses of GC patients [hazard ratio (HR) =3.66,2.45,2.17,3.36,0.41,0.54,95％ confidence interval (CI):2.09-6.41,1.43-4.19,1.17-4.04,1.52-7.41,0.23-0.72,0.31-0.96,P＜0.05].Results of multivariate analysis showed that maximum tumor dimension ≥ 5 cm and grade Ⅲ of histological grade were independent risk factors affecting prognoses of GC patients (HR=3.21,2.17,95％CI:1.63-6.32,1.18-3.99,P＜0.05),and postoperative adjuvant chemotherapy and high expression of Tensin1 protein were independent protective factors affecting prognoses of GC patients (HR=0.50,0.44,95％CI:0.28-0.90,0.24-0.82,P＜0.05).Conclusion High expression of Tensin1 protein may inhibit GC metastasis,and it is also an independent protective factor affecting prognoses of GC patients.

Premature ovarian insufficiency (POI) is characterized by amenorrhea before age 40 with raised FSH level and decreased E2 level. POI, as a main reason for infertility, poses great threat on patients. physical and psychological health.By reviewing clinical trials of acupuncture in treating premature ovarian insufficiency, this study focuses on the significance and feasibility of patient registry about acupuncture therapy for premature ovarian insufficiency. Patient registry can be used in collecting real-world evidence and exploring effective intervention to improve pregnancy rate

With the advent of social aging, the development of intelligent multifunctional nursing beds that are suitable for hospitals, nursing homes, homes and the like has a wide range of applications, this paper presents an intelligent nursing bed design based on Internet of Things technology. The design uses STM32F103 as the central processor. The design is divided into nursing bed module based on tri-fold structure, central control module based on data processing, weight scale module based on weight detection, power supply module based on system power supply and host computer module based on user operation. The design uses a closed control mode, greatly improving the bed control accuracy. Experimental tests showed that under the action of the intelligent control bed control system, the error rate of bed position information driven bedboard can be less than 2%, which has high accuracy and stability.
Beds ; Equipment Design ; Hospitals ; Internet ; Monitoring, Physiologic ; Nursing Homes ; Technology

Objective: To analyze the premature death probability and cause-eliminated life expectancy of cardiovascular disease, cancer, chronic respiratory disease and diabetes in Chongqing residents in 2016 so as to provide recommendation for non-communicable diseases (NCDs) prevention and control in Chongqing. Methods: Death cases of Chongqing Municipality between January 1^st and December 31^st, 2016 were reported through death case registry system of national center for disease prevention and control. Death cases were sorted by international classification of disease (ICD-10). Mortality rate, standardized mortality rate, constituent ratio, premature death probability, life expectancy, and cause-eliminated life expectancy of four major NCDs were analyzed. Results: A total of 218 004 death cases were reported in Chongqing, 2016, and the mortality rate was 731.73/100 000. Of them, a total of 179 637 death cases of the four major NCDs including cardiovascular disease, cancer, chronic respiratory disease and diabetes were reported, accounting for 82.40% of all death cases. The mortality rate and standardized mortality rate of four major NCDs was 602.95/100 000 and 455.82/100 000, respectively. The premature death probability of four major NCDs was 15.96%, and males (25.39%) had a higher premature death probability than females (10.78%). The premature death probability of cardiovascular disease, cancer, chronic respiratory disease, and diabetes were 6.01%, 8.32%, 2.05%, and 0.43%, respectively. Life expectancy would increase by 6.02, 3.19, 1.89, and 0.19 years, after eliminating cardiovascular disease, cancer, chronic respiratory disease and diabetes respectively. Conclusion The premature death probability of major NCDs was high in Chongqing, and males had a higher premature death probability than females did. Intervention and health management of the population should be conducted according to different gender-based risk factors to reduce the premature death probability.

OBJECTIVETo evaluate the impact of health educators' intervention on knowledge, attitude and behavior among rural residents and the feasibility of this intervention mode.

METHODSUsing stratified cluster random sampling method, three towns and five villages in Yongchuan district, Chongqing municipality were selected from February to November, 2013. One or two health educators from each village were recruited by recommendation or voluntary registration. A total of 30 health educators were recruited and trained. Health educators who passed the exam of the training conducted the intervention and training of knowledge and skill about non-communicable disease (NCD) prevention and control for over 30 rural residents who lived nearby aged over 18 years old, could take care of themselves and complete questionnaire independently. 900 residents were selected as the study samples before and after the intervention. Questionnaire surveys were conducted before and after the intervention to evaluate the effect. Changes of knowledge and behavior among participants were compared by Chi-square test. Changes of attitude towards NCD prevention and control among participants were compared by two independent t-test.

RESULTSBefore and after the intervention, the cognition rate about diagnostic criteria of hypertension among rural adults was 29.8% (268/900) and 67.9% (611/900), respectively(χ(2)=261.58, P<0.001). The cognition rate about risk factors of hypertension was 22.9% (206/900) and 78.2% (704/900), respectively(χ(2)=551.19, P<0.001). The cognition rate about the prevention measure of hypertension was 37.2% (335/900) and 88.0% (792/900) , respectively(χ(2)=495.64, P<0.001). The cognition rate about complications of hypertension was 15.4% (139/900) and 68.9% (620/900), respectively(χ(2)=527.07, P<0.001). The cognition rate about diagnostic criteria of diabetes was 12.9% (116/900) and 50.3% (453/900), respectively(χ(2)=291.85, P<0.001). The cognition rate about the criteria of risk population of diabetes was 8.6% (77/900) and 62.0% (558/900), respectively(χ(2)=562.94, P<0.001). The cognition rate about the symptom of diabetes was 29.8% (268/900) and 83.3% (750/900), respectively(χ(2)=525.31, P<0.001). The cognition about the preventive measure of diabetes was 44.7% (402/900) and 89.3% (804/900), respectively(χ(2)=406.06, P<0.001). The cognition rate about 6 g salt intake per person per day among rural adults was 28.0% (252/900) and 84.3% (759/900), respectively(χ(2)=580.04, P<0.001). The cognition about 25 g oil intake per person per day among rural adults was 26.7% (240/900) and 71.4% (643/900), respectively(χ(2)=361.04, P<0.001). The cognition about self-perception of body weight among rural adults was 62.9% (566/900) and 91.9% (827/900), respectively (χ(2)=216.28, P<0.001). The cognition about self-circumference among rural adult was 54.8% (493/900) and 87.7% (789/900), respectively(χ(2)=237.49, P<0.001). The cognition rate of self-blood pressure was 60.5% (544/900) and 70.4% (634/900), respectively(χ(2)=14.92, P<0.001). Before and after the intervention, the scores of the necessity about conducting health education for the public among rural adults was (3.1±0.9 ) and (3.7±0.5 ), respectively(t=20.09, P<0.001). The score of the necessity about unhealthy lifestyle change among rural adults was (3.0±0.9 ) and (3.7±0.6), respectively(t=20.84, P<0.001). The score of the necessity about testing blood pressure and blood glucose regularly among rural adults was (3.0±0.9) and (3.7±0.6), respectively(t=21.07, P<0.001). The score of the necessity about body weight control was (2.9±1.0) and (3.6± 0.8), respectively(t=20.04, P<0.001). The score of the necessity about conducting hypertension screen among high risk population was (3.0±0.9) and (3.7±0.5), respectively(t=22.99, P<0.001). The score of the necessity about conducting diabetes screen among high risk population was (3.0 ± 0.9) and (3.7 ± 0.5), respectively(t=23.22, P<0.001). The score of the necessity about providing instruction service of diet and physical activity for high risk population was (3.0±0.9) and (3.7±0.5), respectively(t=22.41 and 22.87, P< 0.001). Before and after the intervention, the proportion of rural adults seeking counseling service about NCD was 44.0% (396/900) and 64.9% (584/900), respectively(χ(2)=79.17, P<0.001). The proportion of rural adults testing blood pressure in the recent six months was 43.4% (391/900) and 63.1% (568/900), respectively(χ(2)=69.92, P<0.001). The proportion of rural adults who tested blood glucose in the recent six months was 28.6%(257/900) and 48.1% (433/900), respectively(χ(2)=72.80,P<0.001). The proportion of rural adults who controlled body weight consciously was 34.7%(312/900) and 29.3% (264/900), respectively(χ(2)= 5.88,P<0.05).

CONCLUSIONHealth educators' intervention could raise rural participants' awareness and confidence about NCD significantly, but this intervention mode might have little impact on healthy behaviors change in a short time.

Adult ; Blood Glucose ; Blood Pressure ; Body Weight ; China ; Diabetes Mellitus ; Diet ; Health Behavior ; Health Education ; Health Educators ; Health Knowledge, Attitudes, Practice ; Humans ; Hypertension ; Life Style ; Risk Factors ; Rural Population ; Self Concept ; Surveys and Questionnaires

Wearable health monitoring systems that use wearable biosensors capturing human motion and physiological parameters, to achieve the wearer's movement and health management needs. Wearable health monitoring system is a noninvasive continuous detection of human physiological information, data wireless transmission and real-time processing capabilities of integrated system, can satisfy physiological condition monitoring under the condition of low physiological and psychological load. This paper first describes the wearable health monitoring system structure and the relevant technology applied to wearable health monitoring system, and focuses on the current research work what we have done associated with wearable monitoring that wearable respiration and ECG acquisition and construction of electric multi-parameter body area network. Finally, the wearable monitoring system for the future development direction is put forward a simple expectation.
Equipment Design ; Humans ; Monitoring, Ambulatory ; instrumentation ; Movement

Objective To investigate the prevalence of smoking, smoking cessation, passive smoking and awareness of the dangers of tobacco in population in Chongqing and provide evidence for developing prevention and control measures.Methods A total of 5 400 residents aged ≥ 18 years were selected from 9 districts/counties in Chongqing through stratified multi-stage cluster sampling and face-to-face interviews were conducted among them.Indicators as current smoking rates, smoking cessation rates and passive smoking rates were calculated by the weight of age proportions from 2010 population census.The analytical method was based on complex sampling design.Results The current smoking rate of the residents aged ≥ 18 years was 27.4％ (male: 53.5％ and female: 1.1％), which was highest in age group 40-50 years (58.4％) for males.The current smoking rate among rural residents was higher than that in urban residents.The prevalence of daily cigarette smoking was 27.5％, which was significantly higher in southeastern Chongqing.The rate of passive smoking was 52.4％.Among daily smokers, the mean number of cigarettes smoked was 17.5 per day (men: 17.6 per day;women: 13.5 per day).The daily smoked cigarette number in males was higher in age group 40-50 years (20.1 per day) and those with junior middle school education level (18.9 per day).The proportion of the current smokers who smoked more than 20 cigarettes per day (the rate of heavy smoker) was higher in males than in females and in rural residents than in urban residents.The proportion of heavy smokers was 59.3％, which was highest in age group 40-50 years (66.8％),followed by those with junior middle school educational level (65.2％).The average age of smokers when they stared to smoke was 20.8 years old, which was low in males and rural residents.About 80.2％ of the smokers stared to smoke under 25 years old, and 70.3％ of the smokers stared to smoke between 15 and 25 years old.The overall rate of smoking cessation was 20.1％ and the successful smoking cessation rate was 13.7％.The two rates increased with age, the successful smoking cessation rate was lowest in age group 18-40 years (4.8％).The awareness of the tobacco risk related knowledge seemed poor among the residents, only 19.6％ of the residents were aware that smoking could cause serious diseases (stoke, heart disease and lung cancer).21.9％ of the residents were aware that passive smoking could cause serious diseases (heart disease, lung disease and lung cancer).Conclusion Current prevalence of smoking in males in Chongqing remains at a high level,indicating that the publicity programs on the tobacco risk related knowledge needs to be strengthened and the tobacco control needs more efforts.The tobacco control in Chongqing is still facing serious challenge.