Objective To investigate the clinical characteristics of severe mycoplasma pneumoniae pneumonia(SMPP)in children.Methods Clinical data of SMPP children who were hospitalized in the pediatric intensive care unit of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology from January 1st,2018 to December 31st,2021 were retrospectively collected,and data of their clinical characteristics were analyzed.Results Among the 84 children with SMPP,children aged 72 months were the most common.The number of elderly group was significantly higher than that in the infant group(59 vs.25,P＜0.05).July witnessed the highest SMPP detection rate.The main clinical manifestations were fever,cough and extrapulmonary symptoms.In all,73.8％of the children had changes in pulmonary signs,and 33.3％of them had extrapul-monary complications during the course of the disease.The positive rate of metagenomic next-generation sequencing(mNGS)in bronchoalveolar lavage fluid was 100.0％,and the positive rate of nucleic acid detection was 80.5％,which was higher than oth-er detection methods.Age,admitted oxygen flow,and lactate dehydrogenase(LDH)values were independent risk factors for ad-vanced respiratory support for SMPP,including CPAP and invasive ventilators.Conclusion High and long-time fever,as well as serious extrapulmonary complications are common characteristics among SMPP children.The younger the children,the more se-vere the lung lesions.Bronchoalveolar lavage with bronchoalveolar lavage solution mNGS is a rapid and highly specific diagnostic method for children with SMPP.

Objective To investigate the effect of Shenmai injection in treating elderly with orthostatic hypotension. Methods The total of 97 cases of patients with orthostatic hypotension were randomly divided into 2 groups, which was injected intravenously with 100 mL Shenmai injection once daily as the treatment group, with 100 mL glucose as the control.The treatment lasted 14 days. The clinical symptom score, the difference of blood pressure, the P￣selectin, and the platelet maximum aggregation were measured. Results Compared with the control, Shenmai injection significantly reduced the clinical symptom scores of patients (P<0.05), lowered the difference of blood pressure for upright and supine significantly (P<0.05), decreased the platelet maximum aggregation and P￣selectin remarkably (P<0.05). Conclusion Shenmai injection significantly reduces the difference of blood pressure for upright and supine of the elderly with orthostatic hypotension, and inhibits the activities of platelets, thus improves the clinical symptoms.

Objective To analyze the prevalence and orthostatic blood pressure changes in subjects with symptomatic orthostatic hypotension (OH),and to observe the relation between symptoms and orthostatic blood pressure change in this population.Methods A total of 193 subjects who consulted physicians due to OH related symptoms were selected,and divided into three groups:young (n =37),middle-aged (n =66) and elder (n =90).Height,body weight,waist circumference,hip circumference and resting heart rate were measured.Symptom scores of every subject were obtained.CAVI and ABI were measured.Blood pressure including recumbent position,orthostatic systolic and diastolic blood pressure was measured at the morning and at the afternoon on two separate examination days with at least one week interval.After that,orthostatic changes in systolic blood pressure (OCs) and orthostatic changes in diastolic blood pressure (OCd) were calculated.Results OH prevalence was 32.6％ in this cohort.The prevalence of three groups was similar [young:32.4％,middle-aged:25.8％,and elderly:37.8％,respectively (P ＞0.05)].Only 9 cases (14.29％ of confirmed OH cases) reached the OH diagnostic criteria with equal or more than 2 times orthostatic blood pressure measurements.OH was diagnosed in 63 patients during the 4 times orthostatic blood pressure check,of which 19.5％ to 57.14％ cases were diagnosed with single orthostatic blood pressure check.Age,weight,body mass index,waist-to-hip ratio,smoking,drinking habit,sex,coronary heart disease,hypertension,Parkinson's disease,stroke history,antihypertensive drug use were similar between OH group and non-OH group.Height,waist circumference,hip circumference,and resting heart rate were significantly lower in OH group than in non-OH group (P ＜ 0.05).The values of the factors in OH group were lower.CAVI was 8.45 ±0.19 in non-OH group and 8.37 ±0.27 in OH group (P ＞ 0.05),ABI was significantly lower in OH group than in non-OH group (1.004 ± 0.013 vs.1.051 ± 0.009,P ＜ 0.01).Conclusion The prevalence of OH in people with related symptoms is high.Repeated orthostatic blood pressure measurements can improve OH detection rate.

Objective To study the value of electronic administration analysis system used for pre-hospitalrecords in comparison with statistic data processed manually. Method The data of 'first aid medical records'collected from June 26, 2007 to December 26, 2007 in Wuxi Emergency Center, Wuxi, China were taken for anal-ysis. The items for comparison included the average number of emergency patients monthly, percentage of intra-venous infusion, proportion of ECG and blood oxygen saturation monitoring, rate of blood glucose measurement,number of pre-hospital treatment, frequency of using medical devices and time taken for answer to inquires. Thecomparison was carried out between statistic data processed manually and those processed electronically. ResultsBetween two different methods of statistic process, there were no significant in all items ( P > 0.05) except theshorter time required for electronic process to answer the inquires (P<0.01). Conclusions The electronic ad-ministration analysis system for the records of emergency patients is fully developed to meet the expectation in termsof quick answer to inquries with credibly and precisely numerical values.