Small cell carcinoma (SmCC) is a type of neuroendocrine tumor commonly originating in the lung, with only about 2-4% of cases arising at extrapulmonary sites. Extrapulmonary SmCC of the head and neck has a poor prognosis and a high rate of distant metastasis. The paranasal sinus is a rare location for extrapulmonary SmCC and only a few related papers have been published to date. We report a rare case of SmCC originating from the sphenoid sinus in a patient with a recurrent pituitary tumor with a literature review.

Small cell carcinoma (SmCC) is a type of neuroendocrine tumor commonly originating in the lung, with only about 2-4% of cases arising at extrapulmonary sites. Extrapulmonary SmCC of the head and neck has a poor prognosis and a high rate of distant metastasis. The paranasal sinus is a rare location for extrapulmonary SmCC and only a few related papers have been published to date. We report a rare case of SmCC originating from the sphenoid sinus in a patient with a recurrent pituitary tumor with a literature review.

Nasal polyps are inflammatory lesions of sinonasal tissue that are associated with chronic rhinosinusitis, allergic reaction, and other diseases. Although it is the most common cause of nasal polyps, chronic inflammation of the nasal cavity is not common in children. When nasal polyps are found in childhood, it is important to investigate the cause, such as immunodeficiency disease, cystic fibrosis, primary ciliary dyskinesia, and other syndromes such as Woakes’ syndrome. We report a child who presented with nasal polyps combined with bronchiectasis with a review of related literature.

Background and Objectives: For maxillary sinus diseases, it is not easily determined whether it is of the sinus or dental origin as the root of a tooth is located in the maxillary sinus; hence the need to find the pathologic origin for better clinical results. The purpose of this study was to define the characteristics of patients who had needed to consult both a dentist and an otolaryngologist with respect to the diagnosis and management.Subjects and Method Thirty-one patients who visited the department of dentistry and ENT between 2014 and 2018 were included in the study. Patients with dental implant sinusitis were excluded. We restrospectively reviewed the medical records for chief complaints, assessment, diagnose, treatment, and prognosis of the patients. Results: Of 31 patients, 13 patients were diagnosed with odontogenic rhinosinusitis (ORS), 5 with postoperative cheek cyst (POCC), 2 with radicular cyst without ORS, 7 with sinusitis, and 4 with other diseases. Thirteen patients underwent combined operation and 5 at each department. Follow-up periods was about 6.5 months. There was no disease recurrence except one patients with POCC. Conclusion There needs to be an active consultation with the dentistry department in case of unilateral sinusitis and past history of dental treatment temporally or when patients show positive findings in CT.

The oculogyric crisis is a type of acute dystonia characterized by the spasmodic movement of the eyeball, usually upward, and each spasm lasts from seconds to hours. This phenomenon can be caused by the administration of dopaminergic receptor blocking agents. There was a previous report of the oculogyric crisis induced by clebopride, a dopaminergic receptor blocking agent in a patient who took the medicine for several days. We report a 16-year-old female with an oculogyric crisis induced by a single administration of the same drug. Her oculogyric crisis was completely resolved by benzodiazepine

Lymphoma is a malignant tumor arising from the lymphoid tissue. Chronic inflammation can make lymphocyte accumulation and proliferation in the mucous membrane. Sustained accumulation of these persistent changes in the lymphoid tissues may be responsible for the development of mucosa-associated lymphoid tissue (MALT) lymphoma. Although multiple cranial nerve palsy have been reported in various lymphoma, it has never been reported in MALT lymphoma. A 39-year-old man reported of facial palsy and subsequent vocal fold palsy. MALT lymphoma was diagnosed as involving the parotid gland, nasopharynx, and the skull base. Vocal palsy and facial palsy were successfully recovered after chemotherapy.

Animal models have been used to elucidate the pathophysiology of varying diseases and to provide insight into potential targets for therapeutic intervention. Although alternatives to animal testing have been proposed to help overcome potential drawbacks related to animal experiments and avoid ethical issues, their use remains vital for the testing of new drug candidates and to identify the most effective strategies for therapeutic intervention. Particularly, the study of metabolic diseases requires the use of animal models to monitor whole-body physiology. In line with this, the National Institute of Food and Drug Safety Evaluation (NIFDS) in Korea has established their own animal strains to help evaluate both efficacy and safety during new drug development. The objective of this study was to characterize the response of C57BL/6NKorl mice from the NIFDS compared with that of other mice originating from the USA and Japan in a chemical-induced diabetic condition. Multiple low-dose treatments with streptozotocin were used to generate a type-1 diabetic animal model which is closely linked to the known clinical pathology of this disease. There were no significantly different responses observed between the varying streptozotocin-induced type-1 diabetic models tested in this study. When comparing control and diabetic mice, increases in liver weight and disturbances in serum amino acids levels of diabetic mice were most remarkable. Although the relationship between type-1 diabetes and BCAA has not been elucidated in this study, the results, which reveal a characteristic increase in diabetic mice of all origins are considered worthy of further study.
Amino Acids ; Amino Acids, Branched-Chain ; Animal Experimentation ; Animal Testing Alternatives ; Animals ; Ethics ; Japan ; Korea ; Liver ; Metabolic Diseases ; Metabolomics* ; Mice* ; Models, Animal ; Pathology, Clinical ; Physiology ; Streptozocin

BACKGROUND/OBJECTIVES: Turanose, α-D-glucosyl-(1→3)-α-D-fructose, is a sucrose isomer which naturally exists in honey. To evaluate toxicity of turanose, acute and subchronic oral toxicity studies were conducted with ICR mice. MATERIALS AND METHODS: For the acute oral toxicity study, turanose was administered as a single oral dose [10 g/kg body weight (b.w.)]. In the subchronic toxicity study, ICR mice were administered 0, 1.75, 3.5, and 7 g/kg b.w. doses of turanose daily for 13 weeks. RESULTS: No signs of acute toxicity, including abnormal behavior, adverse effect, or mortality, were observed over the 14-day study period. In addition, no changes in body weight or food consumption were observed and the median lethal dose (LD₅₀) for oral intake of turanose was determined to be greater than 10 g/kg b.w. General clinical behavior, changes in body weight and food consumption, absolute and relative organ weights, and mortality were not affected in any of the treatment group for 13 weeks. These doses also did not affect the macroscopic pathology, histology, hematology, and blood biochemical analysis of the mice examined. CONCLUSION: No toxicity was observed in the acute and 13-week subchronic oral toxicology studies that were conducted with ICR mice. Furthermore, the no-observed-adverse-effect level is greater than 7 g/kg/day for both male and female ICR mice.
Animals ; Body Weight ; Female ; Hematology ; Honey ; Humans ; Male ; Mice* ; Mice, Inbred ICR ; Mortality ; No-Observed-Adverse-Effect Level ; Organ Size ; Pathology ; Sucrose ; Toxicology

Minimal invasive surgery (MIS) has rapidly gained acceptance for the management of a wide variety of pediatric diseases. The evolution of minimally invasive surgery (MIS) in children, especially newborns, has been delayed because of the limited working space and unique physiology. With the development of smaller instruments and advanced surgical skills, many of the initial obstacles have been overcome. MIS in children has been used in specialized centers with excellent results, and its application in Korea has been increasing recently. Obvious advantages include better cosmoses, less trauma, and better postoperative musculoskeletal function, especially after thoracic procedures. However, prospective randomized trials and high-level evidence of the benefits of MIS are still scarce. Questions to be answered in the upcoming years will therefore include identify both advantages and potential disadvantages of MIS, especially in neonates. In this review, recent surveys regarding use of MIS by the Korean Association of Pediatric Surgeons were also discussed.
Child ; Humans ; Infant, Newborn ; Korea* ; Minimally Invasive Surgical Procedures ; Pediatrics ; Physiology ; Prospective Studies ; Surgeons

The purpose of this study was to evaluate the surgical feasibility of and survival outcome after laparoscopy in obese Korean women with endometrial cancer which has recently been increasing. We reviewed the medical records of the patients treated at our medical institution between 1999 and 2012. The patients were divided into three groups, non-obese (Body Mass Index [BMI]<25.0), overweight (BMI 25-27.99), and obese (BMI> or =28.0). These patient groups were compared in terms of their clinical characteristics, treatment methods, as well as surgical and survival outcomes. In total, 55 of the 278 eligible patients were obese women. There were no differences in the three groups in terms of the proportion of patients who underwent lymphadenectomy, their cancer stage, histologic type, type of adjuvant treatment administered, intra-, post-operative, and long-term complications, operative time, number of removed lymph nodes, blood loss, and duration of hospitalization (P=0.067, 0.435, 0.757, 0.739, 0.458, 0.173, 0.076, 0.124, 0.770, 0.739, and 0.831, respectively). The Disease-Free Survival (DFS) times were 139.1 vs. 121.6 vs. 135.5 months (P=0.313), and the Overall Survival (OS) times were 145.2 vs. 124.8 vs. 139.5 months (P=0.436) for each group, respectively. Obese women with endometrial cancer can, therefore, be as safely managed using laparoscopy as women with normal BMIs.
Adult ; Aged ; Body Mass Index ; Disease-Free Survival ; Endometrial Neoplasms/complications/*diagnosis/mortality ; Female ; Humans ; Hysterectomy ; Length of Stay ; Lymph Node Excision ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Obesity/complications/*diagnosis ; Republic of Korea ; Retrospective Studies ; Survival Rate ; Treatment Outcome