Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved in synthesis of reduced glutathione (GSH), and investigated the associated upstream signaling cascades. By activating nuclear factor-erythroid 2-related factor (Nrf2), galangin treatment significantly increased expression of glutamate-cysteine ligase catalytic subunit (GCLC) and glutathione synthetase (GSS). This activation of Nrf2 depended on extracellular signal-regulated kinases (ERKs) and protein kinase B (AKT) signaling. Inhibition of GSH in galangin-treated cells attenuated the protective effect of galangin against the deleterious effects of UVB. Our results reveal that galangin protects human keratinocytes by activating ERK/AKT-Nrf2, leading to elevated expression of GSH-synthesizing enzymes.
Catalytic Domain ; Extracellular Signal-Regulated MAP Kinases ; Glutamate-Cysteine Ligase ; Glutathione Synthase ; Glutathione* ; Humans* ; Keratinocytes* ; Proto-Oncogene Proteins c-akt

Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal genetic disease caused by a PTCH mutation. The disease is characterized by multiple basal cell carcinomas of the skin, multiple keratocystic odontogenic tumors (KCOTs) in the jaw, palmar and/or plantar pits, bifid ribs, ectopic calcification of the falx cerebri, and skeletal abnormalities. Early diagnosis is difficult in many cases because there may be a number of systemic symptoms. The purpose of this study is to report the case of a 12-year-old girl who was hospitalized with multiple KCOTs that occurred in the upper and lower jaws. Through characteristic clinical symptoms and radiologic findings, she was finally diagnosed as having NBCCS. This study also aims to organize the symptoms often observed in Korea using previously published case reports to provide useful information for the early diagnosis of NBCCS.
Basal Cell Nevus Syndrome* ; Carcinoma, Basal Cell ; Child ; Early Diagnosis ; Female ; Humans ; Jaw ; Korea ; Odontogenic Cysts ; Odontogenic Tumors ; Ribs ; Skin

Cleft Lip ; Cleft Palate ; Humans ; Infant ; Male ; Mouth ; Mouth Floor ; Palate ; Palate, Soft ; Uvula

Biopsy ; Carcinoma, Squamous Cell ; Dentigerous Cyst ; Epithelium ; Follow-Up Studies ; Humans ; Jaw ; Mandible ; Mouth Mucosa ; Odontogenic Cysts ; Recurrence

Adult ; Female ; Hemangioma ; Humans ; Mouth ; Mouth Floor ; Neurilemmoma ; Peripheral Nerves ; Schwann Cells ; Tongue

Acetic Acid ; Chloroform ; Ethanol ; Humans ; Odontogenic Cysts ; Odontogenic Tumors ; Recurrence ; World Health Organization

Ethanolamine ; Head ; Hemangioma ; Laser Therapy ; Neck ; Oleic Acid ; Oleic Acids ; Sclerotherapy ; Vascular Malformations

INTRODUCTION: The enlargement and deformation of the orbit give rise to a visible enophthalmos. As a consequence, a disturbance of eye motility together with double images is likely to occur. This study examined the degree of enophthalmos according to the extent of orbital wall fracture and volume of herniated orbital tissue in blowout fractures of the medial and inferior orbital wall. MATERIALS AND METHODS: This study was performed on patients diagnosed with medial and inferior orbital wall fractures at the Department of Oral and maxillofacial surgery, Chonbuk National University Hospital from 2007 to 2009. The patients' age, gender, etiology of fracture and degree of enophthalmos were investigated. The changes in the degree of enophthalomos, diplopia and ocular motility restriction after operation were examined. RESULTS: The degree of enophthalomos increased with increasing extent of orbital wall fracture and volume of herniated orbital tissue. CONCLUSION: Whether to perform the operation is decided after measuring the extent of the orbital wall fracture and volume of herniated orbital tissue using computed tomography (CT), time for the decision of operation can be shortened. This can cause a decrease in the complications of orbital wall fractures.
Diplopia ; Enophthalmos ; Eye ; Humans ; Orbit ; Surgery, Oral

Electromyography ; Facial Nerve ; Facial Paralysis ; Follow-Up Studies ; Humans ; Neural Conduction ; Orthognathic Surgery ; Osteotomy, Sagittal Split Ramus ; Paralysis ; Prognathism

Humans ; Malocclusion ; Mandible ; Osteotomy, Sagittal Split Ramus ; Prognathism ; Recurrence ; Retrospective Studies