1.Accuracy of progress assessment with clear aligners.
Bo LI ; Yimeng XU ; Ruiying SHI ; Yirong HU ; Siying LIU ; Zexu GU
West China Journal of Stomatology 2022;40(6):698-703
		                        		
		                        			OBJECTIVES:
		                        			This study aimed to investigate the accuracy of model superimposition and automatic analysis for upper and lower dentition widths in iTero Progress Assessment during the clear aligner process.
		                        		
		                        			METHODS:
		                        			Nineteen cases were included in this retrospective case control study. Pretreatment dental cast (T0) and post treatment dental cast after staged treatment (T1) were available for three-dimensional (3D) model superimposition. The movements of maxillary teeth in the horizontal plane (cross section) after staged treatment and the widths of upper and lower dentitions were measured by 3D model superimposition in real world and iTero Progress Assessment. The data collected from the two methods were compared.
		                        		
		                        			RESULTS:
		                        			The movements [Median (upper and lower quartiles)] of maxillary teeth in the horizontal plane after staged treatment were 2.31 (1.59, 3.22) and 1.79 (1.21, 3.03) mm in iTero Progress Assessment and 3D model analysis, respectively. Significant difference was observed between the two groups (P<0.05). In the measurement of upper and lower dentition width, four indicators were measured, including intercanine width upper, intermolar width upper, intercanine width lower, and intermolar width lower. Before treatment, the measurement of iTero Progress Assessment were (35.78±2.49), (56.21±2.51), (27.43±1.38), (52.26±2.91) mm, respectively, and actual measurement were (35.77±2.53), (56.17±2.47), (27.40±1.41), (52.30±2.86) mm, respectively, without significant difference (P>0.05). After stage treatment, the measurement of iTero Progress Assessment were (37.37±2.86), (57.76±2.56), (28.89±2.00), (54.16±2.19) mm, respectively, and actual measurement were (37.29±2.94), (57.71±2.63), (28.88±2.05), (54.01±2.15) mm, respectively, and there was no significant difference (P>0.05).
		                        		
		                        			CONCLUSIONS
		                        			The data from iTero Progress Assessment did not coincide with the model superimposition results with palate as reference. The accuracy of model superimposition in iTero Progress Assessment needs further investigation, whereas the arch width analysis is accurate. Therefore, iTero Progress Assessment results should be interpreted with caution by orthodontists in clinical applications.
		                        		
		                        		
		                        		
		                        			Case-Control Studies
		                        			;
		                        		
		                        			Cuspid
		                        			;
		                        		
		                        			Dental Arch
		                        			;
		                        		
		                        			Orthodontic Appliances, Removable
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Humans
		                        			
		                        		
		                        	
3.Esthetic proportions of maxillary anterior tooth among 300 normal occlusion college students in Shanxi province.
Hong Xia YANG ; Feng Lan LI ; Li Mei LI
Chinese Journal of Stomatology 2022;57(4):352-357
		                        		
		                        			
		                        			Objective: To explore the relationship between the width ratios of maxillary anterior teeth, the width/height ratios of maxillary central incisor and the esthetic proportions among individual normal occlusion, and to provide reference for the esthetic design of anterior teeth. Methods: A total of 300 Shanxi Medical University students who were residents from Shanxi province with normal occlusion (110 males, 190 females, aged 18-30 years) were recruited in this study from October 2020 to March 2021. Standardized digital photographs of the maxillary anterior tooth in natural head position were obtained, the perceived width of the maxillary anterior teeth (maxillary central incisors, lateral incisors and canines) on the left and right sides and height of maxillary central incisor were measured on the standardized digital photographs, then the width ratios of adjacent maxillary anterior teeth including the lateral incisor/central incisor width ratio (LI∶CI), the canine/lateral incisor width ratio (C∶LI), and the width/height ratios (W/H ratio) of the maxillary central incisor were calculated. The independent sample t test was used to compare the sex differences of each measurement project, Single sample t test was used to compare the difference of adjacent maxillary anterior teeth width ratios with golden proportion (0.618 and 0.618), Preston proportion (0.66 and 0.84), the recurring esthetic dental (RED) proportion (0.70 and 0.70). The percentage of anterior tooth width/intercanine width was calculated, the number and proportion of teeth conforming to golden percentage (25%, 15%, 10%)±1% or modified golden percentage (22.5%, 15.0%, 12.5%)±1% were calculated. The number and proportion of width/height ratio of maxillary central incisor ranged from 0.75 to 0.85 was counted. Results: The widths of maxillary central incisor, lateral incisor and canine were (8.50±0.52), (6.23±0.53) and (5.18±0.55) mm, respectively, the corresponding tooth of male [(8.74±0.49), (6.37±0.52), (5.41±0.47) mm] was significantly higher than that of female [(8.37±0.50), (6.15±0.52), (5.04±0.54) mm] (t=6.40, 3.55, 6.23,P<0.05). The width ratio of maxillary lateral incisor/central incisor was 0.73±0.05, and there was no significant difference between genders (t=-1.06, P>0.05). The width ratio of canine/lateral incisor was 0.84±0.10, and it was significantly higher in male (0.85±0.10) than in female (0.82±0.10) (t=2.42, P<0.05). Two width ratios of maxillary anterior teeth were significantly different from golden proportion and the RED proportion (t=38.50, 35.74, 11.48, 22.20, P<0.05). The lateral incisor/central incisor was significantly different from that of Preston proportion (t=24.66, P<0.05), while the canine/lateral incisor was not significantly different from that of Preston proportion (t=-0.92, P>0.05). In this study, a total of 0% (0/600) of central incisors, 63.0% (378/600) of lateral incisors and 5.8% (35/600) of canines met the golden percentage±1%. There were 42.8% (257/600) of central incisors, 63.0% (378/600) of lateral incisors and 56.7% (340/600) of canines met the modified golden percentage±1%. The width/height ratio of maxillary central incisors was 0.86±0.08, and there was no significant difference between genders (t=-0.88, P>0.05). Only 36.3% (218/600) of the subjects in this study ranged from 0.75 to 0.85. Conclusions: Gender differences should be considered in the esthetic design of anterior teeth; for the width ratios of maxillary anterior teeth, the golden proportion, the RED proportion and golden percentage do not accord with the natural tooth morphological characteristics of Shanxi nationality college students in normal occlusion. Preston proportion and modified golden percentage are of more reference value. The width/height ratio of maxillary central incisors is different from 0.75-0.85.
		                        		
		                        		
		                        		
		                        			Cuspid/anatomy & histology*
		                        			;
		                        		
		                        			Esthetics, Dental
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Maxilla/anatomy & histology*
		                        			;
		                        		
		                        			Odontometry
		                        			;
		                        		
		                        			Students
		                        			
		                        		
		                        	
4.Analysis of the relationship among maxillary anterior teeth width, anterior arch perimeter and anterior segment depth.
Peng WANG ; Da Jun LI ; Jian Zhang LIU
Journal of Peking University(Health Sciences) 2020;52(1):124-128
		                        		
		                        			OBJECTIVE:
		                        			To analyze the relationship between the width of the maxillary anterior teeth and the anterior arch perimeter, to analyze the change rule of the width of the anterior teeth and the anterior arch perimeter, when altered the convexity of the anterior arch, with the width of the maxillary anterior arch keeping constant, and to provide a reliable basis for later digitized and personalized aesthetic analysis of front teeth.
		                        		
		                        			METHODS:
		                        			In the study, 61 front teeth complete and well-arranged models had been selected from the working models after the prostheses in Department of Prosthodontics, Peking University School and Hospital of Stomatology, including 22 male models and 39 female models. A photograph was taken from the occlusal surface of each model using the fixed magnification with a single lens reflex camera. The width of anterior teeth, the width of anterior arch and the convexity of anterior arch had been measured using the Photoshop software. The ratio of the width of the anterior teeth to the width of the anterior arch was calculated. Keeping the width of anterior arch unchanged, the layer free transformation function used to add or decrease the curvature of the anterior arch from 1-5 mm, each circumference of the anterior arch was measured. According to the proportion of their anterior teeth in the anterior arch perimeter, the width of each anterior teeth crown under different convexities of anterior arch was calculated. SPSS 23.0 was used to analyze the ratio of the width anterior teeth to the anterior arch perimeter and correlation between the convexity of the anterior arch and the width of the anterior teeth.
		                        		
		                        			RESULTS:
		                        			The percentages of the median length of the anterior arch in the central incisor, lateral incisor and canine were 36.2%±1.3%, 30.2%±1.5%, and 33.6%±1.4%, respectively. The proportions were normal distributions and not related to the perimeter of the anterior arch. When the width of the anterior arch was constant, there was a positive correlation between the convexity of anterior arch in the range of 5 mm and the width of anterior teeth or the front arch circumference. With each increase or decrease of 1 mm of the convexity of anterior arch, the width of the middle incisor increased or decreased by about 0.18 mm, the half circumference of the anterior arch increased or decreased by about 0.50 mm.
		                        		
		                        			CONCLUSION
		                        			The width of the anterior teeth in the middle-distal direction remained stable in the anterior arch circumference. Within a certain range, when the width of the maxillary anterior arch remains unchanged, the width of the anterior teeth and the perimeter of the anterior teeth are positively correlated to the convexity of the anterior arch.
		                        		
		                        		
		                        		
		                        			Cuspid
		                        			;
		                        		
		                        			Dental Arch
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Incisor
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Maxilla
		                        			;
		                        		
		                        			Odontometry
		                        			;
		                        		
		                        			Software
		                        			
		                        		
		                        	
5.Esthetic proportions of maxillary anterior teeth of 120 Chinese adults.
Wei Liang WU ; Xiao ZENG ; Xiao Qiang LIU ; Jian Guo TAN
Journal of Peking University(Health Sciences) 2020;52(6):1130-1134
		                        		
		                        			OBJECTIVE:
		                        			To analyze the esthetic proportions of maxillary anterior teeth in term of the apparent widths proportion of the adjacent teeth and width/height ratio of the clinical crown in 120 Chinese adults.
		                        		
		                        			METHODS:
		                        			Maxillary gypsum casts were obtained from the dental laboratories of stomatological hospitals in North China, Southeast China, and Southwest China, according to the inclusion criteria and exclusion criteria. Standardized digital photographs of each cast were recorded. The apparent widths and actual widths and heights of the central incisors, lateral incisors and canines were determined by ImageJ software for the calculation of apparent widths proportion of the adjacent teeth and width/height ratio of the clinical crown. The ideal apparent widths proportion (Golden proportion and Preston proportion) and width/height ratio (0.80) were tested. The gender, arch side, and regional differences were investigated.
		                        		
		                        			RESULTS:
		                        			The apparent widths proportion of the lateral/central incisor was 0.724±0.047, of the canine/lateral incisor was 0.814±0.092. The width/height ratio of the central incisor was 0.848±0.072, of the lateral incisor was 0.834±0.094, of the canine was 0.883±0.098. The esthetic proportions were different from the predicted ideal ratio (P < 0.001). The apparent widths proportion of lateral/central incisor was significantly larger in the right side than that in the left side (0.730± 0.044 vs. 0.718±0.050), and was significantly smaller in North China than that in Southwest China (0.711±0.051 vs. 0.731±0.044). The width/height ratio of the central incisor was significantly larger in the female than that in the male (0.855±0.074 vs. 0.835±0.068), and in the right side than that in the left side (0.855±0.073 vs. 0.842±0.072). The width/height ratio of the lateral incisor was significantly larger in the female than that in the male (0.843±0.097 vs. 0.817±0.084).
		                        		
		                        			CONCLUSION
		                        			The apparent widths proportion of adjacent teeth and the width/height ratio of the clinical crown in Chinese adults are different from the foreigner's. The esthetic proportion parameters have significant population specificity, and the measurements cannot be generalized as well as it should be applied with caution.
		                        		
		                        		
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Asians
		                        			;
		                        		
		                        			China
		                        			;
		                        		
		                        			Cuspid
		                        			;
		                        		
		                        			Esthetics
		                        			;
		                        		
		                        			Esthetics, Dental
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Maxilla/anatomy & histology*
		                        			;
		                        		
		                        			Odontometry
		                        			;
		                        		
		                        			Tooth Crown/anatomy & histology*
		                        			
		                        		
		                        	
6.Three-dimensional analysis for changes in dentigerous cyst-associated maxillary canines after marsupialization in adolescents.
Yunyi YUAN ; Jingqiu TU ; Jiaqian FAN ; Yonghua LEI
Journal of Central South University(Medical Sciences) 2019;44(2):164-172
		                        		
		                        			
		                        			To observe three-dimensional changes of dentigerous cyst-associated maxillary canines (DCAMC) in adolescents after marsupialization by using cone beam computed tomography (CBCT).
 Methods: A total of 34 DCAMC patients with dentigerous cyst aged 10-14 were divided into central type and lateral type, while canines on the non-cyst side served as a control. A three-dimensional reference frame was set up to analyze the position, angle changes and influential factors for DCAMC by using CBCT before operation and in 3-6 month after operation.
 Results: 1) Compared with pre-operation, there was significant vertical movement in DCAMC after marsupialization. Tip of tooth moved labially while tooth axis inclined mesiodistally; 2) Horizontal, vertical movement and mesiodistal inclination of DCAMC were significantly greater than those in the health side; 3) Compared with the lateral type DCAMC, the central type DCAMC showed a significant changes in labial inclination; 4) Horizontal movement, mesiodistal and labial inclination of lateral type DCAMC were all evidently greater than those of the central type DCAMC; 5) Vertical movement and inclination of DCAMC after marsupialization were significantly correlated to the time interval (r=0.354, 0.374, both P<0.05), while vertical movement of cuspid in health side was significantly negative correlated with the patients' age and the level of root formation (r=-0.506, -0.721, both P<0.01).
 Conclusion: DCAMC in adolescents can obtain obvious changes in position and angles after marsupialization regardless of the level of root formation, which is beneficial for further orthodontic treatment.
		                        		
		                        		
		                        		
		                        			Adolescent
		                        			;
		                        		
		                        			Child
		                        			;
		                        		
		                        			Cone-Beam Computed Tomography
		                        			;
		                        		
		                        			Cuspid
		                        			;
		                        		
		                        			Dentigerous Cyst
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Maxilla
		                        			
		                        		
		                        	
7.Effect of orthodontic tooth movement on keratinized gingival width.
Gao Nan WANG ; Jian JIAO ; Yan Heng ZHOU ; Jie SHI
Journal of Peking University(Health Sciences) 2019;51(5):931-936
		                        		
		                        			OBJECTIVE:
		                        			The relationship between the orthodontic tooth movement and the change of keratinized gingival width was analyzed by measuring the keratinized gingival width and position of the teeth before and after 28 orthodontic treatments.
		                        		
		                        			METHODS:
		                        			The photos were matched to the model and the width of the keratinized gingival was obtained by measuring the length of the crown, and the keratinized gingiva. The pre- and post-treatment models were overlapped on rapidform 2006 and the change of tooth position before and after orthodontic movement could be accurately measured, and the relationship between tooth intrusion and extrusion, retraction and forward movement, torque variation and keratinized gingival width was statistically investigated.
		                        		
		                        			RESULTS:
		                        			Analysis of the correlation between data before and after treatments for 213 teeth in 28 patients revealed a strong correlation between changes in tooth torque angle and changes in keratinized gingiva width (r=-0.47, P<0.001). In the multi-level linear regression analysis, the correlation between them was verified (regression coefficient<0, P<0.001), and there was no significant correlation between the intrusion and retraction of the teeth and the change of the width of keratinized gingiva (P>0.05). Regression coefficient was negatively relative to the reference incisor between the teeth for the canines and premolars (canine regression coefficient=-0.35, premolar regression coefficient=-0.38, P<0.05). Therefore, the study found that there was a strong negative correlation between the changes in tooth torque angle and width of keratinized gingival (r=-0.41, P<0.001), that is, an increase in positive torque led to the reduction of width of keratinized gingiva, and on the contrary the increase of negative torque would cause the width of keratinized gingiva increase. There was no significant correlation between the intrusion and extrusion of the teeth for the width of keratinized gingiva. The sensitivity of different teeth for the width of keratinized gingiva differed, with incisor compared with canines and premolars that were more prone to keratinized gingiva width changes.
		                        		
		                        			CONCLUSION
		                        			Tooth movement during orthodontics affected the width of the keratinized gingiva width, and the increase in positive torque was more likely to cause a reduction in the width of keratinized gingiva. There was no significant correlation between the intrusion and retraction of the teeth and the change in the width of keratinized gingiva. Incisors were more prone to changes in the width of keratinized gingiva relative to the cuspids and premolars during tooth movement. In the orthodontic process, it is possible to predict the effect of changes in the position of the teeth on the keratinized gingiva width, and attention shoud be to the changes in the keratinized gingiva width.
		                        		
		                        		
		                        		
		                        			Bicuspid
		                        			;
		                        		
		                        			Cuspid
		                        			;
		                        		
		                        			Gingiva
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Incisor
		                        			;
		                        		
		                        			Tooth Movement Techniques
		                        			
		                        		
		                        	
8.Finite element analysis of maxillary anterior teeth retraction of posterior teeth with different alveolar bone absorption heights under orthodontic force.
Zhi-Tao SUN ; Yu-Cheng WANG ; Yu-Mei CUI ; Yang SUN
West China Journal of Stomatology 2019;37(3):265-269
		                        		
		                        			OBJECTIVE:
		                        			This study applied the direct orthodontic force system to explore the applicability of the finite element method in the simulation of alveolar bone absorption and analyze periodontal stress distribution and the overall displacement trend.
		                        		
		                        			METHODS:
		                        			The horizontal balanced alveolar bones of model 2, 3 and 4 were reduced by 2, 4, and 6 mm by deleting elements in reference to the established height of the normal alveolar bone model 1. Then, stress distribution on the posterior set of teeth and initial total tooth displacement under the simulated load of 1.47 N of orthodontic force were investigated.
		                        		
		                        			RESULTS:
		                        			The total displacement of posterior teeth increased and parodontium Von Mises stress gradually increased as the alveolar bone height decreased. The total displacement trend and parodontium stress drastically increased when alveolar bone absorp-tion reached the height of 4 mm.
		                        		
		                        			CONCLUSIONS
		                        			When treating patients with alveolar bone loss, stress should be avoided or drasti-cally reduced to prevent irreversible damage to periodontal tissue and to improve the quality of medical treatment.
		                        		
		                        		
		                        		
		                        			Computer Simulation
		                        			;
		                        		
		                        			Cuspid
		                        			;
		                        		
		                        			Finite Element Analysis
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Maxilla
		                        			;
		                        		
		                        			Periodontal Ligament
		                        			;
		                        		
		                        			Tooth Movement Techniques
		                        			
		                        		
		                        	
9.Association between cervical vertebral maturation stages and dental calcification stages in patients with unilateral complete cleft lip and palate.
Xiao-Xu FANG ; Cun-Hui FAN ; Qing XUE ; Tao XU ; Wen-Lin XIAO ; Zhong-Hui TIAN ; Xiao-Lin XU
West China Journal of Stomatology 2019;37(2):180-186
		                        		
		                        			OBJECTIVE:
		                        			The purpose of the study is to investigate the relationship between dental calcification stages (DCS) and cervical vertebral maturation stages (CVMS) in patients with unilateral complete cleft lips and palates (UCLP) and to provide a theoretical basis for the treatment time selection of cleft lip and palate (CLP) patients.
		                        		
		                        			METHODS:
		                        			A total of 123 UCLP patients and 215 non-CLP subjects were selected. The DCS of the left mandibular canine, premolar, and second molar in non-CLP subjects and on both cleft sides of UCLP patients were assessed utilizing the Demirjian method. CVMS was observed utilizing the Baccetti method. The results were analyzed by Spearman rank correlation, and the correlation coefficients were compared.
		                        		
		                        			RESULTS:
		                        			There was a correlation between the CVMS and the DCS of the left mandibular canine, the first premolar, the second premolar, and the second molar in the non-CLP subjects and on both cleft sides of the UCLP patients (r=0.762-0.864, P<0.05; r=0.809-0.914, P<0.05, respectively). The correlation between the CVMS and the DCS of the mandibular first premolar was highest among the UCLP patients. Except for the first and the second premolars of UCLP females, the correlation between the DCS and the CVMS of the other teeth did not differ among the non-CLP subjects (P>0.05).
		                        		
		                        			CONCLUSIONS
		                        			DCS can be utilized as a biological index to determine the growth development statuses. The correlation between the CVMS and the DCS of the mandibular first premolar was the highest.
		                        		
		                        		
		                        		
		                        			Bicuspid
		                        			;
		                        		
		                        			Calcinosis
		                        			;
		                        		
		                        			Cervical Vertebrae
		                        			;
		                        		
		                        			pathology
		                        			;
		                        		
		                        			Cleft Lip
		                        			;
		                        		
		                        			physiopathology
		                        			;
		                        		
		                        			Cleft Palate
		                        			;
		                        		
		                        			physiopathology
		                        			;
		                        		
		                        			Cuspid
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			
		                        		
		                        	
10.A biomechanical case study on the optimal orthodontic force on the maxillary canine tooth based on finite element analysis.
Jian-Lei WU ; Yun-Feng LIU ; Wei PENG ; Hui-Yue DONG ; Jian-Xing ZHANG
Journal of Zhejiang University. Science. B 2018;19(7):535-546
		                        		
		                        			
		                        			Excessive forces may cause root resorption and insufficient forces would introduce no effect in orthodontics. The objective of this study was to investigate the optimal orthodontic forces on a maxillary canine, using hydrostatic stress and logarithmic strain of the periodontal ligament (PDL) as indicators. Finite element models of a maxillary canine and surrounding tissues were developed. Distal translation/tipping forces, labial translation/tipping forces, and extrusion forces ranging from 0 to 300 g (100 g=0.98 N) were applied to the canine, as well as the force moment around the canine long axis ranging from 0 to 300 g·mm. The stress/strain of the PDL was quantified by nonlinear finite element analysis, and an absolute stress range between 0.47 kPa (capillary pressure) and 12.8 kPa (80% of human systolic blood pressure) was considered to be optimal, whereas an absolute strain exceeding 0.24% (80% of peak strain during canine maximal moving velocity) was considered optimal strain. The stress/strain distributions within the PDL were acquired for various canine movements, and the optimal orthodontic forces were calculated. As a result the optimal tipping forces (40-44 g for distal-direction and 28-32 g for labial-direction) were smaller than the translation forces (130-137 g for distal-direction and 110-124 g for labial-direction). In addition, the optimal forces for labial-direction motion (110-124 g for translation and 28-32 g for tipping) were smaller than those for distal-direction motion (130-137 g for translation and 40-44 g for tipping). Compared with previous results, the force interval was smaller than before and was therefore more conducive to the guidance of clinical treatment. The finite element analysis results provide new insights into orthodontic biomechanics and could help to optimize orthodontic treatment plans.
		                        		
		                        		
		                        		
		                        			Biomechanical Phenomena
		                        			;
		                        		
		                        			Computer Simulation
		                        			;
		                        		
		                        			Cuspid
		                        			;
		                        		
		                        			anatomy & histology
		                        			;
		                        		
		                        			physiology
		                        			;
		                        		
		                        			Dental Models
		                        			;
		                        		
		                        			Finite Element Analysis
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Imaging, Three-Dimensional
		                        			;
		                        		
		                        			Maxilla
		                        			;
		                        		
		                        			Orthodontic Friction
		                        			;
		                        		
		                        			physiology
		                        			;
		                        		
		                        			Periodontal Ligament
		                        			;
		                        		
		                        			physiology
		                        			;
		                        		
		                        			Rotation
		                        			;
		                        		
		                        			Stress, Mechanical
		                        			;
		                        		
		                        			Tooth Movement Techniques
		                        			;
		                        		
		                        			statistics & numerical data
		                        			
		                        		
		                        	
            
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