Objective To analyze the relationship of the volume of 87 brain regions with postnatal age and neurobehavior in full-term neonates.Methods A total of 75 full-term newborns[gestational age(39.38±1.22)weeks;male/female(51/24);postnatal age(11.11±6.67)days]without abnormalities on brain MRI(three-dimensional T1-weighted imaging,3D T1WI)at our hospital between November 2010 and September 2017 were retrospectively included.Based on the template of 87 brain regions,the neonatal brains were divided into 87 brain regions and their volumes were calculated by using V-shape Bottleneck network(VB-Net)deep learning segmentation technique,Pearson partial correlation and regression analysis were used to explore the relationship of the volume of each brain region with postnatal age and neurobehavioral scores.Results After adjusting for gestational age,birth weight,head circumference,body length and sex,66.7％of the regional brain volumes(58/87 brain regions)significantly increased with the postnatal age(correlation coefficient r:0.2-0.7,P＜0.05).The volumes of gray matter in bilateral lentiform nucleus,left caudate nucleus,right occipital lobe,right inferior temporal lobe,and bilateral anterior temporal lobe strongly correlated with the postnatal age(r＞0.50,P＜0.05).The gray matter volume of the right occipital lobe linearly increased with age(slope:100.67),and was positively correlated with behavioral scores(r=0.324,P＜0.01).Conclusion Most of regional brain volumes increase with the postnatal age during the neonatal period,and the fastest growth occurs in primary sensorimotor-related brain regions,presenting the spatial heterogeneity.Partial brain region grows with the development of behavioral ability.

Objective:To investigate the clinical characteristics of patients with epithelioid glioblastoma (ep-GBM) and their influencing factors for survival.Methods:Sixteen ep-GBM patients admitted to Department of Neurosurgery, First Affiliated Hospital of Zhengzhou University from August 2015 to March 2022 were chosen. Clinical data such as age, gender, maximum tumor diameter, degrees of tumor resection, treatments, and immunohistochemical staining-related indexes were obtained. Survival curves of the patients were plotted by Kaplan-Meier method, and differences of progression-free survival (PFS) and overall survival (OS) among patients with different clinical characteristics were compared. Log-rank test was used to compare the survival rates, and Cox proportional risk regression model was constructed to analyze the influencing factors for PFS and OS.Results:In these 16 patients, median OS was 11.8 months and median PFS was 7.0 months. Significant differences in PFS and OS were noted between groups of age<32 years and age≥32 years, between groups of maximum tumor diameter<4.8 cm and diameter≥4.8 cm, and between groups of positive p53 expression and negative p53 expression ( P<0.05). Log-rank test indicated that OS and PFS ratios were significantly different between groups of age<32 years and age≥32 years, between groups of maximum tumor diameter<4.8 cm and diameter≥4.8 cm, between S100 positive group and S100 negative group, between Olig-2 positive group and Olig-2 negative group, and between groups of positive p53 expression and negative p53 expression ( P<0.05). Cox proportional hazard regression model showed that age ( HR=1.070, 95% CI: 1.013-1.134, P=0.016), preoperative maximum tumor diameter ( HR=2.150, 95% CI: 1.142-4.055, P=0.018) and Olig-2 expression ( HR=0.040, 95% CI: 0.003-0.498, P=0.013) had influences in PFS; preoperative maximum tumor diameter ( HR=2.350, 95%CI: 1.149-4.798, P=0.019) and Olig-2 expression ( HR=0.080, 95% CI: 0.007-0.972, P=0.047) had influences in OS. Conclusion:Older ep-GBM patients are prone to progress after surgery; ep-GBM patients with larger tumor diameter and negative Olig-2 expression likely progress and have poor prognosis after surgery.

Aortic aneurysm (AA) is a vascular disease involving the progressive dilation of aorta diameter. It is usually asymptomatic but with high mortality once rupture. Currently, there is no effective pharmacologic treatment. MicroRNA specifically refers to non-coding small RNAs consisting of 19-25 nucleotides. The characteristic of microRNA targeting multiple genes seems to form a complicated regulation network, which receives considerable attention. Emerging studies show that microRNAs are closely related to the occurrence and development of AA. Many microRNAs are involved in multiple cell processes and functions and may participate in the pathogenesis of AA, including endothelial cell dysfunction, inflammatory cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. This article will describe the animal models for AA research and the latest progression of microRNA and AA.

Receptor-interacting protein (RIP) kinase 1 is involved in immune-mediated inflammatory diseases including ulcerative colitis (UC) by regulating necroptosis and inflammation. Our group previously identified TAK-632 (

Objective:To analyze the relationship between physical appearance perfectionism, negative body self, fear of negative evaluation and social appearance anxiety in female patients with psoriasis.Methods:A total of 251 female patients with psoriasis in Xinhua Hospital Affiliated to Medical College of Shanghai Jiaotong University from June 2019 to June 2020 were selected as the subjects. Physical Appearance Perfectionism Scale (PPAS), Social Appearance Anxiety Scale (SAAS), Brief Fear of Negative Evaluation Scale (BFNES) and Negetive Physical Self Scale (Npss) were used in the survey. The correlation of negative body self and negative evaluation fear between the appearance perfectionism and social appearance anxiety of female psoriasis patients was analyzed.Results:The score of physical appearance perfectionism was 49.42±5.32, the score of social appearance anxiety was 58.72±6.24, the score of fear of negative evaluation was 30.59±7.21 and the score of negative physical self was 29.21±6.24. Pearson correlation analysis showed that there was a significant positive correlation among physical appearance perfectionism, social appearance anxiety, fear of negative evaluation and negative physical self ( r value was 0.402-0.488, P<0.01). The mediating effect of negative physical self between physical appearance perfectionism and social appearance anxiety was 0.164 (95% CI 0.082-0.227), the mediating effect of negative body self between physical appearance perfectionism and social appearance anxiety was 0.152 (95% CI 0.079-0.214) and the chain mediating effect of fear of negative evaluation and negative physical self was 0.067 (95% CI 0.025-0.108). Conclusions:Female patients with psoriasis have a high level of physical appearance perfectionism, which can directly affect their social anxiety, while fear of negative evaluation and negative physical self indirectly affect the correlation between appearance perfectionism and social appearance anxiety. Psychological intervention measures should be taken to reduce their psychological burden on their own appearance defects and carry out social anxiety and fear.

Capacity overload is an important pathophysiological change in the development of acute and chronic heart failure and capacity management is a very important part in the management of heart failure. This article starts with the relationship between heart failure and capacity management and reviews the methods of capacity assessment and the commonly used nursing interventions for capacity management. It aims to emphasize the importance and necessity of capacity management for patients with heart failure and provide clinical nurses with the direction of capacity assessment and basis for formulating corresponding nursing measures.

Nursing intervention classification (NIC) is an effective system in documenting nursing work, which can improve nursing quality, strengthen the standard of nursing charging, and promote nursing education and research. In addition, it can be used as a standardized nursing language to satisfy the needs of electronic computerized nursing record. The authors introduced the content of NIC, as well as the advantages found in overseas application and the status of application and research at home. Also presented are the application prospect, research approaches and advices on how to apply the NIC system in clinical practice at home.

Eczema is a common clinical inflammatory skin disease characterized by severe itching and recurrent attacks.Its etiology is complex, including a variety of internal and external factors.The main mechanism is related to the imbalance of Th2immune response, and related inflammatory factors play an important role.Epithelial-derived factor like thymic stromal lymphopoietin and interleukin-33could trigger Th2immune imbalance and promote the secretion of type inflammatory factors such as interleukin-4, interleukin-5, and interleukin-13.These inflammatory factors will further induce eosinophilic granulocytosis and IgE formation.In this paper, the research progress of mechanism of type 2related inflammatory factors in eczema were reviewed, which provided the great significance for treatment.

Objective To grasp the general situation of patent application and authorization of 77 medical and health institutions in Zhejaing,to provide reference and basis for promoting the patent application and conversion.Methods Patent data were searched through Bai Teng net patent database,and SPSS 19.0 was used for statistical analysis.Results The total number of patent application showed a trend of generally rise.There were 1430 valid invention patents in total,among which 264 were invention patents and 1166 utility model patents.The total number of patens as well as invention patents were positive correlated to province GDP GDP and doctors per thousand population (r=0.824,0.812,0.784,0.771 respectively,P＜0.001).The rate of collaborative patent application was 6.28％,and there was a significant difference (α=0.05/3,P＜0.001) in the collaborative patent applications around Hangzhou,provincial and other cities medical and health institutions.Conclusions The total number of patents in 77 medical and health institutions in Zhejaing has reached a certain scale,and the number of patents increase with the economic development and the number of doctors per thousand population.The effective patents present in concentrating in regions,and the proportion of invention patents was low.

Objective? To evaluate the effects of different forms of self-management education on glycosylated hemoglobin (HbA1c) in diabetic patients. Methods? The related clinical randomized controlled trials (RCTs) were retrieved in China National Knowledge Infrastructure (CNKI), VIP, WanFang data and Chinese Biomedical Database (CBM) (key words:diabetes/ self-management/ health education/behavior/ psychology) and in Embase, PubMed, Cochrane (key words:of intervention/ knowledge/ behavior/psychological/ diabetes/ DSME) from building the database to June 2018 as well as in related journals by hand. Then, we evaluated the quality of literature and carried out data analysis with the RevMan5.0. Results? Finally, a total of 16 literatures (evaluating the effects of self-management education in diabetic patients with the outcome indexes of HbA1c) were included with 9 of them in the subgroup of behavior intervention, 4 in the subgroup of elementary knowledge cognitive intervention and 3 in the subgroup of mental intervention. Besides, 3 literatures with the level A and 13 with the level B. Meta-analysis showed that the HbA1c of the subgroup of behavior intervention was with WMD=-0.78, 95%CI (-1.14, -0.41)(P＜ 0.05), HbA1c of the subgroup of elementary knowledge cognitive intervention was with WMD=-0.55, 95%CI (-1.06, -0.04)(P＜ 0.05) and HbA1c of the subgroup of mental intervention was with WMD=-0.55, 95%CI (-1.24, 0.15)(P＞ 0.05). Conclusions? Behavior intervention and elementary knowledge cognitive intervention all have positive effects on HbA1c of diabetic patients. However, whether mental intervention has effects on patients＇ HbA1c has not gotten a final conclusion. We should implement comprehensive self-management education for diabetic patients from many aspects including behavior, cognition and psychology to achieve an ideal effect.