Following the 2011 ban on paraquat sales, Korea has witnessed a significant reduction in the mortality rate associated with acute pesticide poisoning. Traditionally, paraquat and diquat, alongside several highly toxic organophosphates, carbamates, and organochlorine insecticides, have been recognized as culprits in causing fatalities among patients with acute pesticide poisoning. However, despite global efforts to curtail the use of these highly toxic pesticides, certain pesticides still exhibit a level of lethality surpassing their established clinical toxicity profiles. Understanding the clinical progression of these pesticides is paramount for physicians and toxicologists, as it holds the potential to enhance patient prognoses in cases of acute poisoning. This review aims to address the persistence of such highly lethal pesticides, which continue to pose a grave threat to victims of acute poisoning.

Emergency department observation units (EDOUs) transition patients from the ED to dedicated areas where they can receive continuous monitoring. Understanding patient return visits after EDOU discharge is important for optimizing healthcare. The objective of this study was to investigate the correlations between demographic and clinical features and the likelihood of returning to the ED within 30 days following an initial EDOU assessment. Methods This retrospective, observational, cohort study of adult EDOU subjects was conducted between February 1, 2018, and January 31, 2023. Adult patients who were evaluated in an EDOU and returned to an ED within 30 days were compared with those who were assessed in the EDOU but did not return to the ED within 30 days. The analysis took into account multiple visits by the same subject and made adjustments for variables of sex, ethnicity, insurance status, primary diagnosis, and disposition using a generalized linear mixed model. Results A total of 14,910 EDOU encounters was analyzed, and 2,252 patients (15%) returned to the ED within 30 days. The analysis took into account several variables that indicated a significant association with the likelihood of returning to the ED within 30 days. These were sex (P<0.001), ethnicity (P=0.005), race (P<0.001), insurance status (P<0.001), primary diagnosis (P<0.001), and disposition (P<0.001). Emergency severity index and length of stay were not associated with ED return. Conclusion Understanding these factors may guide interventions, enhance EDOU care, and reduce resource strain. Further research should explore these associations and the long-term intervention impacts on improved outcomes.

Hyperbaric oxygen therapy (HBOT) has garnered significant attention as a therapeutic modality with potential benefits across a variety of medical conditions, ranging from wound healing and ischemic conditions to neurologic disorders and radiation-induced tissue damage. HBOT involves the administration of 100% oxygen at higher-than-atmospheric pressures, which increases the amount of oxygen dissolved in body fluids and tissues. Those elevated oxygen levels are proposed to facilitate tissue repair, reduce inflammation, and promote angiogenesis. This case report presents a compelling instance of the usefulness of HBOT in promoting skin perfusion and healing following peripheral tissue injury caused by administration of inotropic and vasopressor agents to a septic shock patient.