Two Korean black goat (approx. 2 and 3 years old) showing diarrhea and chronic weight loss were submitted to Animal and Plant Quarantine Agency. At necropsy, there were thickening of small intestine and enlargement of mesenteric lymph nodes. Microscopically, they had granulomatous enteritis in the small and large intestine and granulomatous lymphadenitis. By polymerase chain reaction (PCR) and acid fast stain, strong positive reaction and acid-fast rod bacteria were detected. According to the result of histopathology and PCR, we confirmed this case as Johne's disease. As far as we know, this is the first report of Johne's disease in Korean black goat.
Animals ; Bacteria ; Crohn Disease ; Diarrhea ; Goats* ; Intestine, Large ; Intestine, Small ; Lymph Nodes ; Lymphadenitis ; Paratuberculosis* ; Pathology ; Plants ; Polymerase Chain Reaction ; Quarantine ; Weight Loss

Epithelial hyperplasia and mucosal infiltration of leukocytes are common features of chronic rhino sinusitis. The epithelium can produce chemo attractant cytokines that may contribute to leukocyte infiltration in rhino sinusitis. IL-8 is a chemokine that can be produced in large amounts by epithelial cells in response to a variety of stimuli including proinflammatory cytokines, bacteria, fungi, and respiratory viruses. This chemokine is not only a potent chemoattractant for, and activator of, neutrophils, but it is also chemotactic for some subsets of T lymphocytes. Moreover, IL-8 has been reported to serve as a chemoattractant for eosinophils from subjects with allergic disease. Thus it is reasonable to hypothesize that this chemokine could contribute to the pathogenesis of chronic rhino sinusitis. This article reviews the role of IL-8 in the pathogenesis of chronic rhino sinusitis.
Bacteria ; Cytokines ; Eosinophils ; Epithelial Cells ; Epithelium ; Fungi ; Hyperplasia ; Interleukin-8* ; Leukocytes ; Neutrophils ; Sinusitis ; T-Lymphocytes

Mucoceles of the paranasal sinuses are benign, locally expansile cysts filled with mucus and lined by the mucoperiosteum of the involved sinus. Orbital symptoms are characteristic in symptomatic maxillary sinus mucoceles, and patients initially consulted ophthalmologists for eyeball displacement, diplopia, proptosis, enophthalmos, epiphora, and rarely decreased visual acuity. Recently, we experienced a case of maxillary sinus mucocele with the destruction of the orbital floor. The mucocele was treated by marsupialization via intranasal and transantral approach, and the large defect of orbital floor was successfully reconstructed using high-density porous polyethylene (Medpor(R), Porex Surgical Inc, College Park, GA). Accurately positioned Medpor implant was observed in the orbital floor after 48 months postoperatively.
Diplopia ; Enophthalmos ; Exophthalmos ; Humans ; Lacrimal Apparatus Diseases ; Maxillary Sinus* ; Mucocele* ; Mucus ; Orbit* ; Paranasal Sinuses ; Polyethylene ; Visual Acuity

No abstract available.
Frontal Sinus*

BACKGROUND AND OBJECTIVES: Adenoid vegetation can induce chronic rhinosinusitis in children by obstruction of the nasopharynx or as a reservoir for bacteria. The aim of this study is to determine the efficacy of adenoidectomy in chronic pediatric rhinosinusitis. Materials and Methods: Symptoms of chronic rhinosinusitis were evaluated in 17 patients who underwent an adenoidectomy between November 2001 and July 2002. Patients' age ranged from 4 to 11 years old. Caregivers of the patients were asked about symptoms of chronic rhinosinusitis, which were nasal obstruction, rhinorrhea, postnasal drainage, headache, cough and sputum, by a 10-graded visual analogue scale of 6 items at preoperative and postoperative 2, 3, 4, 5, 6, 8, 10 and 12 weeks, respectively. We assessed the grades of plain radiographic (Waters' view) findings at postoperative 1, 2 and 3 months consecutively. RESULTS: Symptoms of chronic rhinosinusitis were significantly improved following adenoidectomy. Significant improvement of symptom scores began at postoperative 2 weeks on the average. Plain radiographic findings were significantly improved at postoperative 1 month. After postoperative 7 months, 'Cure' was reported in 9 (53%) of 17 patients. Conclusions: In majority of cases, symptoms and radiographic findings of chronic rhinosinusitis in children are improved by adenoidectomy. Adenoidectomy should be considered as a first-line surgical option for pediatric chronic rhino-sinusitis.
Adenoidectomy* ; Adenoids ; Bacteria ; Caregivers ; Child ; Drainage ; Headache Disorders, Primary ; Humans ; Nasal Obstruction ; Nasopharynx ; Sputum

Mucosa-associated lymphoid tissue (MALT) is a specialized form of lymphiod tissue that may be acquired at sites in response to chronic inflammation. MALT lymphoma is a type of low-grade, B-cell lymphoma within the spectrum of non-Hodgkin's extranodal lymphomas, and may arise within several sites in the head and neck. Because of the differences in the natural history, prognosis, and therapy of MALT lymphoma and other lymphomas, the immunohistochemical and molecular biology studies should be considered in the diagnosis of MALT lymphoma in cases where atypical lymphoid infiltrates into the head and neck. We present a case of advanced staged multifocal MALT lymphoma, which has disseminated into the bone marrow, involving mucosal sites of the ethmoid sinus, hard palate and cheek, but not the gastrointestinal tract, with a review of relevant literature.
Bone Marrow ; Cheek* ; Diagnosis ; Ethmoid Sinus* ; Gastrointestinal Tract ; Head ; Immunohistochemistry ; Inflammation ; Lymphoid Tissue ; Lymphoma ; Lymphoma, B-Cell ; Lymphoma, B-Cell, Marginal Zone* ; Molecular Biology ; Natural History ; Neck ; Palate, Hard* ; Prognosis

Subcutaneous cervicofacial and mediastinal emphysema (SCFME) occur with a variety of disease processes. Most cases involve a passive escape of air from the aerodigestive tract into subcutaneous tissues. Even if the presence of SCFME is not in itself dangerous, prompt recognition of the underlying etiology is essential. Catheterization is a common procedure in the otolaryngologic field, but, clinically, SCFME after catheterization is very rare. Recently, we experienced a case of SCFME after catheterization, so we report this rare case with a review of literatures.
Catheterization* ; Catheters* ; Mediastinal Emphysema* ; Subcutaneous Tissue ; United Nations

Neurilmomma is a benign tumor which originate from the neuroectodermal Schwann cell of cranial, intraspinal, peripheral and autonomic nerve sheath. Although these tumors have been reported to occur throughout the body, the highest incidence, accounting for 25% to 45% of all cases, has been reported in the head and neck area. Except the acoustic neurilemmoma which is the most common in the otolaryngologic fields, neurilemmoma originating from the nasal cavity and paranasal sinus is very rare (about 4%). Recently, the authors have experienced a case of neurilemmoma of nasal cavity and thus presents the clinical and radiolographic findings along with a review of the literature.
Autonomic Pathways ; Head ; Incidence ; Nasal Cavity* ; Neck ; Neural Plate ; Neurilemmoma* ; Neurofibroma ; Neuroma, Acoustic ; S100 Proteins* ; Schwann Cells

BACKGROUND AND OBJECTIVES: Although allergic rhinitis is one of the most common factors associated with the development of chronic rhinosinusitis, the role of allergy in the severity of chronic rhinosinusitis was not well defined. This study is aimed to determine whether the allergy or factors such as nasal polyp, asthma, aspirin sensitivity can induce more extensive chronic rhinosinusitis, and to determine whether the severity of chronic rhinosinusitis depends on the severity of allergy. MATERIALS AND METHODS: A total of 98 chronic rhinosinusitis patients who underwent endoscopic sinus surgery were evaluated. The severity of chronic rhinosinusitis was assessed by CT scores and symptom scores. An allergic prick test, MAST (Multiple-antigen simultaneous test), the total IgE, and a serum eosinophil count were evaluated for diagnosis and assessment of the severity of allergy. Influences of another factors such as nasal polyp, asthma, and aspirin sensitivity to the severity of chronic rhinosinusitis were evaluated. RESULTS: Although the symptom scores of allergic chronic rhinosinusitis patients were greater than those of non-allergic chronic rhinosinusitis patients, there were no CT score differences between the two groups. Differences in the CT scores and symptom scores in allergic chronic rhinosinusitis patients according to the severity of allergy were statistically insignificant. Nasal polyp, asthma, and aspirin sensitivity did not induce more severe chronic rhinosinusitis. CONCLUSION: Allergy may be associated with the development of chronic rhinosinusitis, but the severity of allergy is not correlated to the severity of chronic rhinosinusitis.
Aspirin ; Asthma ; Diagnosis ; Eosinophils ; Humans ; Hypersensitivity* ; Immunoglobulin E ; Nasal Polyps ; Rhinitis

Backgrounds and Objectives : Although the sinus CT (computed tomography) scan has emerged as the preferred method for assessing the extent of chronic rhinosinusitis, the relationship between sinus CT findings and symptom severity in chronic rhinosinusitis has not been established yet. The Lund-Mackay CT staging systems were known as one of the most prevalent methods in assessing the severity of chronic rhinosinusitis. We aimed to determine the relationship between the severity of the Lund- Mackay CT scores and symptom severity, and to determine the relationship between the laterality and symptom severity in chronic rhinosinusitis. MATERIALS AND METHODS: 108 patients who fit the eligiblity and exclusion criteria were evaluated. We scored each CT scan on the Lund-Mackay system and let the patients complete the questionnaires for the rhinosinusitis symptoms. The correlation between the CT scores and the severity of patients' symptoms was assessed. Then, we divided the patients into 4 groups according to the grades of CT scores. And in each group, we subgrouped them according to the CT score differences between the right and left sides. Statistical analyses of symptom scores between subgroups in each group were performed. RESULTS: The CT scores graded by the Lund-Mackay system and symptom scores were correlated significantly (rho=0.365, p< or = 0.0001). According to the laterality of chronic rhinosinusitis, there were no statistically significant differences between CT scores and symptom scores in the subgroups of each group. CONCLUSION: The CT score by the Lund-Mackay system was correlated with the patients-based reports of symptom severity regardless of the laterality of chronic rhinosinusitis. We therefore recommend that the Lund-Mackay system to be adopted as the standard method of measuring the extent of chronic rhinosinusitis.
Humans ; Linear Energy Transfer ; Surveys and Questionnaires ; Tomography, X-Ray Computed