Carotid Artery, Internal/diagnostic imaging* ; Humans ; Oropharynx

Objective: To explore the diagnosis and clinical features of internal carotid artery aneurysm in the skull base. Methods: The data of 15 patients with internal carotid aneurysms in the skull base diagnosed and treated by digital subtraction angiography (DSA) or CT angiography (CTA) in the Provincial Hospital Affiliated to Shandong First Medical University from 1995 to 2017 were collected and analyzed. Among the 15 patients, 12 were males, and 3 were females, aging from 17 to 67 years old, with a median age of 44 years. Thirteen patients were diagnosed by DSA; the other two patients were diagnosed by CTA. Thirteen patients were diagnosed with pseudoaneurysm with the first symptom of epistaxis, in which eight patients underwent head trauma and 5 underwent radiotherapy of skull base tumor. The other two patients were diagnosed with true aneurysm presented headache and cranial nerve disorder. All patients were followed up for 2 to 12 years after treatment to see whether they were cured and survived. Results: Among the eight patients with a history of trauma, five patients were cured by embolization, two patients without embolization died of massive epistaxis, one patient died of progressive cerebral infarction after embolization. Among the five patients with radiotherapy of skull base tumor, one patient died of cerebral infarction after embolization, two patients died out of the hospital due to the recurrence of the primary tumor and intracranial invasion, one patient recovered well after embolization and surgical operation, one patient gave up treatment and died of massive hemorrhage out of hospital. In the other two patients with symptom of headache, one received embolization treatment outside the hospital after receiving mistake operation, and another one gave up treatment and died due to personal reasons. In total, four patients died in hospital, four died out of the hospital, and seven patients survived. Conclusions: Internal carotid artery aneurysm is a high-risk disease of anterior and middle skull base. For patients with epistaxis with a history of trauma and radiotherapy or patients with headaches and cranial nerve disorders, the possibility of the internal carotid artery aneurysm should be considered, in which DSA or CTA examination is essentially required for ensured diagnosis and disease evaluation.. The correct diagnosis and treatment by the otolaryngologist are crucial to the prognosis of the patient.
Adolescent ; Adult ; Aged ; Carotid Artery, Internal/diagnostic imaging* ; Female ; Humans ; Intracranial Aneurysm/therapy* ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Retrospective Studies ; Skull Base/diagnostic imaging* ; Young Adult

Carotid Artery Injuries/etiology* ; Carotid Artery, Internal/diagnostic imaging* ; Foreign Bodies/complications* ; Humans ; Skull ; Skull Base/diagnostic imaging*

Carotid Artery, Internal/diagnostic imaging* ; Ear, Middle ; Humans ; Tomography, X-Ray Computed

Carotid Artery Diseases ; Carotid Artery, Common ; Carotid Artery, Internal/diagnostic imaging* ; Humans ; Xanthomatosis

Objective To retrospectively analyze the characteristics of the traumatic rupture of intracranial internal carotid artery in order to provide reference for forensic expertise examination and identification. Methods A total of 11 autopsy cases of traumatic rupture of intracranial internal carotid artery were collected. The gender, age, cause of injury, blood loss on the scene, location of internal carotid artery rupture, hardening degree of the rupture of the wall, brain injury, blood ethanol content and cause of death were also recorded. Results All 11 cases died on the scene, of which 7 died from traffic accidents, 2 falls from height and 2 from bare handed injuries. None of the 11 victims suffered serious head and body surface injury. The internal carotid artery rupture in the 9 cases of traffic injury and fall from height injury occurred in the cavernous segment. In all these cases, there were transverse fractures of the middle cranial fossa with the carotid sulcus involved, and minor intracranial hemorrhage and brain contusion. In 2 cases of bare handed injuries, internal carotid artery rupture occurred in the ophthalmic artery segment, accompanied by fatal intracranial hemorrhage and diffuse axonal injury, but no skull fracture. All 11 cases showed full-thickness rupture of the vessel wall, and the long axis of the wounds was perpendicular to those of the artery. Conclusion The incidence of intracranial internal carotid artery rupture in high-energy trauma events such as traffic accidents and high falls deserves attention. Injuries of the cavernous segment or ophthalmic segment might be more common. The main injury mechanism of intracranial internal carotid artery rupture might be that the blood vessels were pulled and the bone fragments caused damage.
Accidents, Traffic ; Carotid Artery, Internal/diagnostic imaging* ; Humans ; Retrospective Studies ; Rupture ; Skull Fractures

PURPOSE: Although time-of-flight (TOF)-magnetic resonance angiography (MRA) can clearly depict intracranial arteries, the arterial flow of middle cerebral artery (MCA) is occasionally not detected. We evaluated this phenomenon with reference to cerebrovascular dynamics. MATERIALS AND METHODS: Seventeen patients with suspected occlusion of MCA or internal carotid artery on TOF-MRA were enrolled. All patients underwent CT angiography (CTA) and quantitative cerebral blood flow (CBF) examination for measurement of resting CBF and cerebrovascular reactivity (CVR). Depending on appearance, patients were categorized into three groups. Group A (n=6) had MCA delineation on both MRA and CTA, while groups B (n=6) and C (n=5) had no signal on MRA, but Group B had a MCA delineation on CTA.
Acetazolamide/administration & dosage ; Aged ; Aged, 80 and over ; Carotid Artery, Internal/physiopathology ; Cerebrovascular Circulation ; Computed Tomography Angiography ; Female ; Humans ; Magnetic Resonance Angiography ; Male ; Middle Aged ; Middle Cerebral Artery/diagnostic imaging

OBJECTIVETo assess brush sign (BS) on susceptibility-weighted imaging (SWI) in prediction of hemorrhagic transformation (HT) in patients with acute ischemic stroke (AIS) after intravenous thrombolysis(IVT).

METHODSPatients with acute cerebral ischemic stroke, who had major cerebral artery occlusion (internal carotid artery, middle cerebral artery M1 and M2), treated with intravenous recombinant tissue plasminogen activator (rt-PA) from August 2009 to October 2014 in the Second Affiliated Hospital, Zhejiang University School of Medicine, were enrolled in the study. All patients underwent SWI scanning. The asymmetry index (AI) was defined as the difference of intensity between ischemic and normal hemispheres on the SWI phase map; according to AI values patients were divided into 3 groups: BS=0(n=9), BS=1 (n=39) and BS=2 (n=18). The relationships between BS and HT and the clinical outcome among the 3 groups were analyzed.

RESULTSSixty-six patients aged 68 ± 13 years were included in the study, including 44 males (67%) and 22 females (33%), and 44 (67%) with acute ischemic stroke. The mean pre-treatment National Institutes of Health Stroke Scale (NIHSS) score was 13 (6-17), and the onset to needle time was (252 ± 88) min. Twenty-six (39.4%) patients had HT, including 18 cases (27.3%) with HI and 8 cases (12.1%) with PH; BS was observed more frequently in HT group than non-HT group. Binary logistic regression analysis showed that BS was independently associated with HT of patients with acute ischemic stroke following IVT (OR=2.589, 95% CI: 1.080-6.210, P=0.033). In those without reperfusion after IVT, patients with higher BS grade had higher HT rate (P=0.023).

CONCLUSIONBrush sign on SWI can be used for predicting hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke.

Administration, Intravenous ; Aged ; Aged, 80 and over ; Brain Ischemia ; diagnosis ; drug therapy ; Carotid Artery, Internal ; pathology ; Diagnostic Imaging ; Female ; Humans ; Male ; Middle Aged ; Recombinant Proteins ; administration & dosage ; therapeutic use ; Stroke ; diagnosis ; drug therapy ; Thrombolytic Therapy ; Tissue Plasminogen Activator ; administration & dosage ; therapeutic use ; Treatment Outcome ; United States

OBJECTIVETo explore the ideal screw entry point and optimal trajectory for anterior C1 lateral mass screw internal fixation, and provide an anatomical basis for the technique of anterior C1 lateral mass screw placement.

METHODSA radiographic analysis of the anatomy of the C1 lateral mass using Computed tomography, CT scan was performed in cervical spine of 56 healthy Chinese adults (28 males, 28 females; mean age, 36.5 years; age range, 18-55 years), by using the Mimics software to reconstruct the 3-D morphology of C1 lateral mass and measuring the inside, middle and outside effective height of the C1 lateral mass in front and back. Measuring the C1 lateral mass safe width with different extraversion angles range from 0° to 30° with a uniform interval of 5°, to find out the ideal extraversion angle. Measuring the range of sagittal angle, to find out the ideal sagittal angle.

RESULTSThe inside (H1), middle (H3) and outside (H5) effective height of the C1 lateral mass in front is 6.67 mm, 12.09 mm, and 17.51 mm, the inside (H2), middle (H4) and outside(H6) effective height of the C1 lateral mass in back is 8.17 mm, 13.20 mm, and 18.22 mm. When the extraversion angle choose 0°, 5°, 10°, 15°, 20°, 25°, 30°, and δ, the relative results of safe width (SW) of lateral mass were 4.73 mm, 5.36 mm, 5.90 mm, 6.33 mm, 6.44 mm, 5.70 mm, 4.38 mm, 6.95 mm averagely. The mean distance along the atlas anterior surface between the anterior tubercle and the screw entry point was 12.80 mm, the mean distance from the inferior border of the lateral mass to the screw entry point was 6.87 mm. The range of sagittal angle is 24.22° (-17.74°∼6.48°) .

CONCLUSIONSThe ideal extraversion angle was 21.14°. The mean distance along the atlas anterior surface between the anterior tubercle and the screw entry point was 12.80 mm. The mean distance from the inferior border of the lateral mass to the screw entry point was 6.87 mm. The ideal sagittal angle is -5.63°. These measurements may facilitate anterior C1 lateral mass screw fixation decreasing the risk of injury to the spinal cord, vertebral artery, and internal carotid artery theoretically. Delineating the individual anatomy in each case with CT scan before surgery is recommended.

Adolescent ; Adult ; Bone Screws ; Carotid Artery, Internal ; diagnostic imaging ; Cervical Atlas ; Cervical Vertebrae ; diagnostic imaging ; surgery ; Female ; Fracture Fixation, Internal ; instrumentation ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Reconstructive Surgical Procedures ; Tomography, X-Ray Computed ; Vertebral Artery ; diagnostic imaging ; Young Adult

Epistaxis is commonly encountered in otorhinolaryngologic practice. However, severe and recurrent epistaxis is rarely seen, especially that originating from a pseudoaneurysm of the intracavernous internal carotid artery (ICA). We herein present the case of a 32-year-old man who was involved in a motor vehicle accident and subsequently developed recurrent episodes of profuse epistaxis for the next three months, which required blood transfusion and nasal packing to control the bleeding. Computed tomography angiography revealed a large intracavernous ICA pseudoaneurysm measuring 1.7 cm × 1.2 cm × 1.0 cm. The patient underwent emergent four-vessel angiography and coil embolisation and was discharged one week later without any episode of bleeding. He remained asymptomatic after three-month and one‑year intervals. This case report highlights a large intracavernous ICA pseudoaneurysm as a rare cause of epistaxis, which requires a high index of suspicion in the right clinical setting and emergent endovascular treatment to prevent mortality.
Accidents, Traffic ; Adult ; Aneurysm, False ; diagnostic imaging ; etiology ; surgery ; Carotid Artery Injuries ; Carotid Artery, Internal ; diagnostic imaging ; pathology ; surgery ; Coronary Angiography ; methods ; Embolization, Therapeutic ; Epistaxis ; etiology ; Humans ; Male ; Tomography, X-Ray Computed