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BACKGROUND/AIMS: Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors. METHODS: We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis. RESULTS: The mean age (+/-SD) of the patients was 56.3+/-10.7 years, and the male : female ratio was 3.6:1. The mean tumor size was 0.5+/-0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7+/-1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4+/-25.4 months, and no recurrences were observed. CONCLUSIONS: In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.
Adult ; Age Factors ; Aged ; Carcinoid Tumor/*diagnosis/metabolism/pathology ; Colonoscopy ; Female ; Humans ; Immunohistochemistry ; Ki-67 Antigen/*metabolism ; Male ; Middle Aged ; Prognosis ; Rectal Neoplasms/*diagnosis/metabolism/pathology ; Retrospective Studies ; Sex Factors

3.Can Ki-67 Expression Predict the Prognosis in Low Grade Rectal Carcinoid Tumor?.

Seun Ja PARK

The Korean Journal of Gastroenterology 2013;61(2):61-62

4.Cervical carcinoid with high-grade intraepithelial neoplasia: report of a case.

Hai LI ; Fang BAO ; Yu-fei LI ; Yi-long DAI ; Ying XIANG ; Zhi-hong ZHANG

Chinese Journal of Pathology 2013;42(5):347-348

5.Thyroid follicular carcinoma-like renal cell carcinoma: report of a case.

Xiu-zhen WU

Chinese Journal of Pathology 2013;42(9):622-623

6.Lipid-rich variant of pancreatic endocrine tumour with inhibin positivity and microscopic foci of microcystic adenoma-like areas: emphasis on histopathology.

Anuradha Calicut Kini RAO ; Vidya MONAPPA ; Prashanth SHETTY

Singapore medical journal 2013;54(2):e31-4

Pancreatic endocrine tumours (PETs) are uncommon tumours with typical morphology characterised by relatively uniform cuboidal cells arranged in nests and festoons, with distinctive nuclear salt-and-pepper chromatin. A lipid-rich variant poses diagnostic difficulties in the midst of other pancreatic tumours and metastatic goblet cell carcinoid. A 22-year-old man presented with symptoms of abdominal pain and jaundice. His liver function test and blood glucose level were normal, but computed tomography of the abdomen suggested the presence of a tumour in the head of the pancreas. Specimen obtained by pancreaticoduodenectomy revealed an infiltrating yellow-tan tumour composed of nests and a cribriform arrangement of polygonal vacuolated cells with pyknotic nuclei, along with focal classical areas of PET. Two foci of early serous microcystic adenoma were seen. Immunohistochemistry contributed to the arrival of a conclusive diagnosis. Von Hippel-Lindau disease was excluded in our patient, as other supportive classical features of the syndrome were absent.
Adenoma ; Blood Glucose ; metabolism ; Carcinoid Tumor ; diagnosis ; pathology ; Humans ; Immunohistochemistry ; Lipids ; chemistry ; Male ; Neoplasm Metastasis ; Neuroendocrine Tumors ; diagnosis ; pathology ; Pancreatic Neoplasms ; diagnosis ; pathology ; Pancreaticoduodenectomy ; Young Adult

10.Gastric carcinoid tumor with micro-mucinous adenocarcinoma: report of a case.

Hua YANG ; Li-Bo SUN ; Ying WANG ; Lian-You WANG ; Ya-Nan CUI

Chinese Journal of Pathology 2010;39(12):848-849

1.Bronchial metastasis of thyroid follicular carcinoma: report of a case.

2.Prognostic Significance of Ki-67 Expression in Rectal Carcinoid Tumors.

3.Can Ki-67 Expression Predict the Prognosis in Low Grade Rectal Carcinoid Tumor?.

4.Cervical carcinoid with high-grade intraepithelial neoplasia: report of a case.

5.Thyroid follicular carcinoma-like renal cell carcinoma: report of a case.

6.Lipid-rich variant of pancreatic endocrine tumour with inhibin positivity and microscopic foci of microcystic adenoma-like areas: emphasis on histopathology.

7.Clinicopathologic observation of renal carcinoid tumors.

8.A Case of Rectal Carcinoid Tumor with Cystic Degeneration.

9.Carcinoid tumor of common bile duct: report of a case in pediatric patient.

10.Gastric carcinoid tumor with micro-mucinous adenocarcinoma: report of a case.

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