Objective:To analyze risk factors of medical adhesive-related skin injury (MARSI) at the site of peripherally inserted central catheters (PICC) in patients with tumor palliative care.Methods:A total of 315 patients who underwent tumor palliative care in the People's Hospital of Guangxi Zhuang Autonomous Region from June 2019 to June 2020 were selected as the research objects by the convenient sampling method, and they were divided into the occurrence group and the non-occurrence group according to whether they had MARSI. The differences of general and clinical data between the two groups were compared. Logistic regression analysis was used to analyze the risk factors of MARSI.Results:Among 315 tumor palliative care patients, 100 cases (31.75%) had MARSI at PICC catheterization site. Compared with the non-occurrence group, the occurrence group showed an increase in the proportion of PICC puncture site on the medial side of the biceps brachii, PICC catheterization frequency greater than or equal to 2 times, large angle removal of the dressing, semi permeable dressing type, dressing replacement frequency of 2 times per week and delayed maintenance of PICC catheters, and the differences were statistically significant ( P<0.05). Logistic regression analysis showed that PICC puncture site on the medial side of the biceps brachii, PICC catheterization frequency greater than or equal to 2 times, large angle removal of the dressing, semi permeable dressing type, dressing replacement frequency of 2 times per week and delayed maintenance of PICC catheters were all risk factors for MARSI at the PICC catheterization site in tumor palliative treatment patients ( P<0.05) . Conclusions:There are many risk factors for MARSI at the PICC catheter site in patients undergoing tumor palliative care and targeted preventive measures need to be taken in clinical practice to reduce MARSI.

Bartter′s syndrome(BS) is a rare renal tubular diseases and an autosomal recessive hereditary disease. The characteristic findings are hypokalemia, metabolic alkalosis, and raised serum renin and aldosterone levels. Combination of metabolic syndrome with Bartter′s syndrome has not been reported so far. Here in, we report a case in order to call attention to the diagnosis and treatment of typical Bartter′s syndrome combined with metabolic syndrome.

Objective To investigate the level of chemotactic factors(CXCL5 and CXCL8)in hepatic fibrosis and cirrhosis tissue.Methods Hepatic tissues were obtained from 9 patients with hepatic hemangioma (hepatic hemangioma group),10 patients with liver fibrosis(liver fibrosis group)and 11 patients with liver cirrhosis(1iver cirrhosis group)at Nanfang Hospital from May 2008 to May 2009.The contents of CXCL5 and CXCL8 in hepatic tissue were assayed by ELISA.All data were analyzed by one-way ANOVA,Pearson rank correlation or Spearman correlation.Results The contents of CXCL5 and CXCL8 were(0.8±0.7)ng/g and(6.2±3.7)ng/g in hepatic hemangioma group,(2.0±2.0)ng/g and(11.6±3.5)ng/g in liver fibrosis group and (17.1±4.8)ng/g and(12.3±3.9)ng/g in liver cirrhosis group,with significant difference among the 3 groups (F=60.050,7.690,P＜0.05).The expression of CXCL5 was correlated with the content of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and prothrombin time(PT)(r=0.502,0.468,0.523,P＜0.05):the expression of CXCL8 was correlated with the content of ALT,AST.total bilirubin and PT(r=0.477,0.504,0.537,0.431,P＜0.05).Conclusions With the aggravation of hepatic fibrosis,the contents of CXCL5 and CXCL8 are increased with different patterns.The changes of CXCL5 and CXCL8 are related with the injury of liver,but the changes of CXCL5 and CXCL8 do not correspond with the degree of the injury of liver.

Objective To observe the changes in serum High Sensitive C-reactive Protein(hs-CRP)in newly dignosed type 2 diabetic patients after treament with short-term intensive insulin aspart and investigate the relationship of inflammatory factors with insulin resistant.Methods30 newly dignosed ty 2 diabetic were treated by 14 d intensive aspart treament,the levels of fasting plasma glucose(FPG),2hours postprandial glucose(2hPG),insulin and C-peptide,hs-CRP,the mean area under the curve(AUC)of insulin and C-peptide,insulin resistance index(HOMA-A),insulin secretion index(HOMA-B)were compared before and after transient intensive nsulin aspart treament.ResultsAfter the treament,FPG,2hPG,hs-CRP and HOMA-A were significantly decreased(P