1.Force and moment analysis of clear aligners: Impact of material properties and design on premolar rotation
Dong-Woo KIM ; Hyun-Jun LEE ; Ki Beom KIM ; Sung-Hun KIM ; Seong-Sik KIM ; Soo-Byung PARK ; Youn-Kyung CHOI ; Yong-Il KIM
The Korean Journal of Orthodontics 2025;55(3):212-223
		                        		
		                        			 Objective:
		                        			To quantitatively analyze and compare the forces and moments generated by thermoformed polyethylene terephthalate glycol (PETG) and direct-printed TC-85 clear aligners (CAs), with various margin designs, during premolar rotation. 
		                        		
		                        			Methods:
		                        			In total, 132 CAs were fabricated and divided into four groups (n = 33 per group). Group C consisted of thermoformed PETG aligners with a 2 mm gingival margin. Group E comprised direct-printed TC-85 aligners with equi-gingival margin, whereas Group G utilized direct-printed TC-85 aligners with 2 mm gingival margins.Finally, Group T featured direct-printed TC-85 aligners with an additional 1 mm thickness at the mesial embrasure. The forces and moments were measured using a 6-axis force/moment transducer at 2°, 3°, and 4° of rotation. All measurements were conducted at 37°C to simulate intraoral conditions. Forces were measured in the buccolingual, anteroposterior, and vertical directions, while moments were measured in the mesiodistal, buccolingual, and rotational planes.  
		                        		
		                        			Results:
		                        			The PETG aligners (Group C) showed significantly increased buccal and posterior force across the rotation angles (P < 0.05), whereas the intrusive force remained consistent. In contrast, the TC-85 aligners maintained consistent forces across all rotation angles.Direct-printed aligners demonstrated significantly lower intrusive forces than PETG aligners (P < 0.001). Group T exhibited reduced unwanted forces while maintaining effective rotational moments. Furthermore, all direct-printed aligners showed more predictable force delivery patterns than thermoformed aligners.  
		                        		
		                        			Conclusions
		                        			Direct-printed TC-85 aligners demonstrated superior force consistency and reduced unwanted side effects compared with traditional PETG aligners. Although marginal design modifications did not significantly improve rotational efficiency, they effectively reduced unwanted intrusive forces. 
		                        		
		                        		
		                        		
		                        	
2.A randomized controlled trial comparing liquid skin adhesives and staplers for surgical wound management
Hyeon Woo BAE ; Seung Yoon YANG ; Ga Yoon KU ; Sohye LEE ; Eun-Joo JUNG ; Seulkee PARK ; Yoon Bin JUNG ; Jihong KIM ; Byung Soh MIN
Annals of Surgical Treatment and Research 2025;108(3):143-149
		                        		
		                        			 Purpose:
		                        			Despite the widespread use of liquid skin adhesives (LSA), concerns persist regarding the increase in wound care costs. This study aimed to investigate the cost-effectiveness of LSA for surgical wound management. 
		                        		
		                        			Methods:
		                        			In this prospective, open-label, single-center randomized controlled trial, adults aged 19 years and older who were scheduled for elective minimally invasive colorectal surgeries were included. The participants were randomly divided into 2 groups: an n-butyl cyanoacrylate skin adhesive was used in the experimental group (LSA group), while a surgical skin stapler was employed in the control group (stapler group). The primary outcome measure was the sum of the total time required for wound management. 
		                        		
		                        			Results:
		                        			A total of 58 patients were randomly assigned to 2 groups, with 29 patients in each group. The findings revealed comparable wound complication rates in the 2 groups (8 out of 29 in the LSA group vs. 5 out of 29 in the stapler group, P = 0.530). Notably, the LSA group had a significantly shorter wound management time (median 235 seconds vs. 1,201 seconds, P < 0.001) and similar wound management cost (median US dollar [USD] 50.6 vs. USD 54.6, P = 0.529) compared to the stapler group. Subgroup analysis showed that the LSA group had a shorter management time for uncomplicated wounds and a lower cost for complicated wounds. 
		                        		
		                        			Conclusion
		                        			LSA not only provides a safe alternative but also offers a resource-efficient option for wound management compared to staplers. 
		                        		
		                        		
		                        		
		                        	
3.Force and moment analysis of clear aligners: Impact of material properties and design on premolar rotation
Dong-Woo KIM ; Hyun-Jun LEE ; Ki Beom KIM ; Sung-Hun KIM ; Seong-Sik KIM ; Soo-Byung PARK ; Youn-Kyung CHOI ; Yong-Il KIM
The Korean Journal of Orthodontics 2025;55(3):212-223
		                        		
		                        			 Objective:
		                        			To quantitatively analyze and compare the forces and moments generated by thermoformed polyethylene terephthalate glycol (PETG) and direct-printed TC-85 clear aligners (CAs), with various margin designs, during premolar rotation. 
		                        		
		                        			Methods:
		                        			In total, 132 CAs were fabricated and divided into four groups (n = 33 per group). Group C consisted of thermoformed PETG aligners with a 2 mm gingival margin. Group E comprised direct-printed TC-85 aligners with equi-gingival margin, whereas Group G utilized direct-printed TC-85 aligners with 2 mm gingival margins.Finally, Group T featured direct-printed TC-85 aligners with an additional 1 mm thickness at the mesial embrasure. The forces and moments were measured using a 6-axis force/moment transducer at 2°, 3°, and 4° of rotation. All measurements were conducted at 37°C to simulate intraoral conditions. Forces were measured in the buccolingual, anteroposterior, and vertical directions, while moments were measured in the mesiodistal, buccolingual, and rotational planes.  
		                        		
		                        			Results:
		                        			The PETG aligners (Group C) showed significantly increased buccal and posterior force across the rotation angles (P < 0.05), whereas the intrusive force remained consistent. In contrast, the TC-85 aligners maintained consistent forces across all rotation angles.Direct-printed aligners demonstrated significantly lower intrusive forces than PETG aligners (P < 0.001). Group T exhibited reduced unwanted forces while maintaining effective rotational moments. Furthermore, all direct-printed aligners showed more predictable force delivery patterns than thermoformed aligners.  
		                        		
		                        			Conclusions
		                        			Direct-printed TC-85 aligners demonstrated superior force consistency and reduced unwanted side effects compared with traditional PETG aligners. Although marginal design modifications did not significantly improve rotational efficiency, they effectively reduced unwanted intrusive forces. 
		                        		
		                        		
		                        		
		                        	
4.Force and moment analysis of clear aligners: Impact of material properties and design on premolar rotation
Dong-Woo KIM ; Hyun-Jun LEE ; Ki Beom KIM ; Sung-Hun KIM ; Seong-Sik KIM ; Soo-Byung PARK ; Youn-Kyung CHOI ; Yong-Il KIM
The Korean Journal of Orthodontics 2025;55(3):212-223
		                        		
		                        			 Objective:
		                        			To quantitatively analyze and compare the forces and moments generated by thermoformed polyethylene terephthalate glycol (PETG) and direct-printed TC-85 clear aligners (CAs), with various margin designs, during premolar rotation. 
		                        		
		                        			Methods:
		                        			In total, 132 CAs were fabricated and divided into four groups (n = 33 per group). Group C consisted of thermoformed PETG aligners with a 2 mm gingival margin. Group E comprised direct-printed TC-85 aligners with equi-gingival margin, whereas Group G utilized direct-printed TC-85 aligners with 2 mm gingival margins.Finally, Group T featured direct-printed TC-85 aligners with an additional 1 mm thickness at the mesial embrasure. The forces and moments were measured using a 6-axis force/moment transducer at 2°, 3°, and 4° of rotation. All measurements were conducted at 37°C to simulate intraoral conditions. Forces were measured in the buccolingual, anteroposterior, and vertical directions, while moments were measured in the mesiodistal, buccolingual, and rotational planes.  
		                        		
		                        			Results:
		                        			The PETG aligners (Group C) showed significantly increased buccal and posterior force across the rotation angles (P < 0.05), whereas the intrusive force remained consistent. In contrast, the TC-85 aligners maintained consistent forces across all rotation angles.Direct-printed aligners demonstrated significantly lower intrusive forces than PETG aligners (P < 0.001). Group T exhibited reduced unwanted forces while maintaining effective rotational moments. Furthermore, all direct-printed aligners showed more predictable force delivery patterns than thermoformed aligners.  
		                        		
		                        			Conclusions
		                        			Direct-printed TC-85 aligners demonstrated superior force consistency and reduced unwanted side effects compared with traditional PETG aligners. Although marginal design modifications did not significantly improve rotational efficiency, they effectively reduced unwanted intrusive forces. 
		                        		
		                        		
		                        		
		                        	
5.A randomized controlled trial comparing liquid skin adhesives and staplers for surgical wound management
Hyeon Woo BAE ; Seung Yoon YANG ; Ga Yoon KU ; Sohye LEE ; Eun-Joo JUNG ; Seulkee PARK ; Yoon Bin JUNG ; Jihong KIM ; Byung Soh MIN
Annals of Surgical Treatment and Research 2025;108(3):143-149
		                        		
		                        			 Purpose:
		                        			Despite the widespread use of liquid skin adhesives (LSA), concerns persist regarding the increase in wound care costs. This study aimed to investigate the cost-effectiveness of LSA for surgical wound management. 
		                        		
		                        			Methods:
		                        			In this prospective, open-label, single-center randomized controlled trial, adults aged 19 years and older who were scheduled for elective minimally invasive colorectal surgeries were included. The participants were randomly divided into 2 groups: an n-butyl cyanoacrylate skin adhesive was used in the experimental group (LSA group), while a surgical skin stapler was employed in the control group (stapler group). The primary outcome measure was the sum of the total time required for wound management. 
		                        		
		                        			Results:
		                        			A total of 58 patients were randomly assigned to 2 groups, with 29 patients in each group. The findings revealed comparable wound complication rates in the 2 groups (8 out of 29 in the LSA group vs. 5 out of 29 in the stapler group, P = 0.530). Notably, the LSA group had a significantly shorter wound management time (median 235 seconds vs. 1,201 seconds, P < 0.001) and similar wound management cost (median US dollar [USD] 50.6 vs. USD 54.6, P = 0.529) compared to the stapler group. Subgroup analysis showed that the LSA group had a shorter management time for uncomplicated wounds and a lower cost for complicated wounds. 
		                        		
		                        			Conclusion
		                        			LSA not only provides a safe alternative but also offers a resource-efficient option for wound management compared to staplers. 
		                        		
		                        		
		                        		
		                        	
6.Force and moment analysis of clear aligners: Impact of material properties and design on premolar rotation
Dong-Woo KIM ; Hyun-Jun LEE ; Ki Beom KIM ; Sung-Hun KIM ; Seong-Sik KIM ; Soo-Byung PARK ; Youn-Kyung CHOI ; Yong-Il KIM
The Korean Journal of Orthodontics 2025;55(3):212-223
		                        		
		                        			 Objective:
		                        			To quantitatively analyze and compare the forces and moments generated by thermoformed polyethylene terephthalate glycol (PETG) and direct-printed TC-85 clear aligners (CAs), with various margin designs, during premolar rotation. 
		                        		
		                        			Methods:
		                        			In total, 132 CAs were fabricated and divided into four groups (n = 33 per group). Group C consisted of thermoformed PETG aligners with a 2 mm gingival margin. Group E comprised direct-printed TC-85 aligners with equi-gingival margin, whereas Group G utilized direct-printed TC-85 aligners with 2 mm gingival margins.Finally, Group T featured direct-printed TC-85 aligners with an additional 1 mm thickness at the mesial embrasure. The forces and moments were measured using a 6-axis force/moment transducer at 2°, 3°, and 4° of rotation. All measurements were conducted at 37°C to simulate intraoral conditions. Forces were measured in the buccolingual, anteroposterior, and vertical directions, while moments were measured in the mesiodistal, buccolingual, and rotational planes.  
		                        		
		                        			Results:
		                        			The PETG aligners (Group C) showed significantly increased buccal and posterior force across the rotation angles (P < 0.05), whereas the intrusive force remained consistent. In contrast, the TC-85 aligners maintained consistent forces across all rotation angles.Direct-printed aligners demonstrated significantly lower intrusive forces than PETG aligners (P < 0.001). Group T exhibited reduced unwanted forces while maintaining effective rotational moments. Furthermore, all direct-printed aligners showed more predictable force delivery patterns than thermoformed aligners.  
		                        		
		                        			Conclusions
		                        			Direct-printed TC-85 aligners demonstrated superior force consistency and reduced unwanted side effects compared with traditional PETG aligners. Although marginal design modifications did not significantly improve rotational efficiency, they effectively reduced unwanted intrusive forces. 
		                        		
		                        		
		                        		
		                        	
7.A randomized controlled trial comparing liquid skin adhesives and staplers for surgical wound management
Hyeon Woo BAE ; Seung Yoon YANG ; Ga Yoon KU ; Sohye LEE ; Eun-Joo JUNG ; Seulkee PARK ; Yoon Bin JUNG ; Jihong KIM ; Byung Soh MIN
Annals of Surgical Treatment and Research 2025;108(3):143-149
		                        		
		                        			 Purpose:
		                        			Despite the widespread use of liquid skin adhesives (LSA), concerns persist regarding the increase in wound care costs. This study aimed to investigate the cost-effectiveness of LSA for surgical wound management. 
		                        		
		                        			Methods:
		                        			In this prospective, open-label, single-center randomized controlled trial, adults aged 19 years and older who were scheduled for elective minimally invasive colorectal surgeries were included. The participants were randomly divided into 2 groups: an n-butyl cyanoacrylate skin adhesive was used in the experimental group (LSA group), while a surgical skin stapler was employed in the control group (stapler group). The primary outcome measure was the sum of the total time required for wound management. 
		                        		
		                        			Results:
		                        			A total of 58 patients were randomly assigned to 2 groups, with 29 patients in each group. The findings revealed comparable wound complication rates in the 2 groups (8 out of 29 in the LSA group vs. 5 out of 29 in the stapler group, P = 0.530). Notably, the LSA group had a significantly shorter wound management time (median 235 seconds vs. 1,201 seconds, P < 0.001) and similar wound management cost (median US dollar [USD] 50.6 vs. USD 54.6, P = 0.529) compared to the stapler group. Subgroup analysis showed that the LSA group had a shorter management time for uncomplicated wounds and a lower cost for complicated wounds. 
		                        		
		                        			Conclusion
		                        			LSA not only provides a safe alternative but also offers a resource-efficient option for wound management compared to staplers. 
		                        		
		                        		
		                        		
		                        	
8.Force and moment analysis of clear aligners: Impact of material properties and design on premolar rotation
Dong-Woo KIM ; Hyun-Jun LEE ; Ki Beom KIM ; Sung-Hun KIM ; Seong-Sik KIM ; Soo-Byung PARK ; Youn-Kyung CHOI ; Yong-Il KIM
The Korean Journal of Orthodontics 2025;55(3):212-223
		                        		
		                        			 Objective:
		                        			To quantitatively analyze and compare the forces and moments generated by thermoformed polyethylene terephthalate glycol (PETG) and direct-printed TC-85 clear aligners (CAs), with various margin designs, during premolar rotation. 
		                        		
		                        			Methods:
		                        			In total, 132 CAs were fabricated and divided into four groups (n = 33 per group). Group C consisted of thermoformed PETG aligners with a 2 mm gingival margin. Group E comprised direct-printed TC-85 aligners with equi-gingival margin, whereas Group G utilized direct-printed TC-85 aligners with 2 mm gingival margins.Finally, Group T featured direct-printed TC-85 aligners with an additional 1 mm thickness at the mesial embrasure. The forces and moments were measured using a 6-axis force/moment transducer at 2°, 3°, and 4° of rotation. All measurements were conducted at 37°C to simulate intraoral conditions. Forces were measured in the buccolingual, anteroposterior, and vertical directions, while moments were measured in the mesiodistal, buccolingual, and rotational planes.  
		                        		
		                        			Results:
		                        			The PETG aligners (Group C) showed significantly increased buccal and posterior force across the rotation angles (P < 0.05), whereas the intrusive force remained consistent. In contrast, the TC-85 aligners maintained consistent forces across all rotation angles.Direct-printed aligners demonstrated significantly lower intrusive forces than PETG aligners (P < 0.001). Group T exhibited reduced unwanted forces while maintaining effective rotational moments. Furthermore, all direct-printed aligners showed more predictable force delivery patterns than thermoformed aligners.  
		                        		
		                        			Conclusions
		                        			Direct-printed TC-85 aligners demonstrated superior force consistency and reduced unwanted side effects compared with traditional PETG aligners. Although marginal design modifications did not significantly improve rotational efficiency, they effectively reduced unwanted intrusive forces. 
		                        		
		                        		
		                        		
		                        	
9.Association Between Plasma Anti-Factor Xa Concentrations and Large Artery Occlusion in Patients With Acute Ischemic Stroke Taking Direct Oral Anticoagulants for Non-valvular Atrial Fibrillation
Dae-Hyun KIM ; Byung-Cheol KWAK ; Byeol-A YOON ; Jae-Kwan CHA ; Jong-Sung PARK ; Min-Sun KWAK ; Kwang-Sook WOO ; Jin-Yeong HAN
Annals of Laboratory Medicine 2024;44(5):459-462
		                        		
		                        		
		                        		
		                        	
10.Association Between Plasma Anti-Factor Xa Concentrations and Large Artery Occlusion in Patients With Acute Ischemic Stroke Taking Direct Oral Anticoagulants for Non-valvular Atrial Fibrillation
Dae-Hyun KIM ; Byung-Cheol KWAK ; Byeol-A YOON ; Jae-Kwan CHA ; Jong-Sung PARK ; Min-Sun KWAK ; Kwang-Sook WOO ; Jin-Yeong HAN
Annals of Laboratory Medicine 2024;44(5):459-462
		                        		
		                        		
		                        		
		                        	
            
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