Background: and Purpose: In this study we aimed to find the association between neuropsychological performance and body mass index (BMI) in patients with mild cognitive impairment (MCI). In addition, we investigated the effects of the apolipoprotein E (APOE) genotype in the relationship between the BMI and cognition in MCI. Methods: We enrolled a cohort of 3,038 subjects with MCI aged 65–90 from the Clinical Research Center for Dementia of South Korea and a dementia cohort of the Ewha Womans University Mokdong Hospital. MCI patients were classified into three subgroups according to the Asian standard of BMI. We compared cognitive performances between groups by one-way analysis of variance. To investigate the effects of the APOE genotype, we used multivariate linear regression models after adjusting for possible confounders. Results: Even though normal BMI groups were younger, had more females, and had less comorbidities, the higher BMI groups had better cognitive functions. Among subjects with APOE ε4 carriers, there was a positive relationship between the BMI and the memory task alone. Conclusions Our findings suggested that higher BMI in patients with MCI were associated with better cognitive performance. The effects of the APOE ε4 genotype in the associations between BMI and cognition were distinguishing. Therefore, according to physical status, APOE ε4 genotype-specific strategies in the assessments and treatments may be necessary in elderly patients with MCI.

No abstract available.
Eosinophilia ; Eosinophils ; Folliculitis ; Mucous Membrane ; Naproxen ; Skin Diseases, Vesiculobullous

No abstract available.
Eosinophilia ; Eosinophils ; Folliculitis ; Mucous Membrane ; Naproxen ; Skin Diseases, Vesiculobullous

No abstract available.
Dermatitis, Atopic

No abstract available.
Dermatitis, Atopic

Febrile ulceronecrotic pityriasis lichenoides et varioliformis acuta (PLEVA), or febrile ulcerative Mucha-Haberman disease (FUMHD) is very rare, but potentially lethal variants of PLEVA. This subtype is characterized by rapidly progressive ulceronecrotic lesions and systemic manifestations, such as high fever, gastrointestinal, neurological, cardiologic and pulmonary involvement, and rheumatologic manifestations. Several treatments with variable response have been challenged, such as systemic steroid, antibiotics, methotrexate, dapsone, cyclosporine and ultraviolet therapy. But there is no standard therapy for FUMHD to date. We report a 59-year-old woman with FUMHD, who recurred after discontinuation of systemic steroid, but successfully treated with oral cyclosporine.
Anti-Bacterial Agents ; Cyclosporine ; Dapsone ; Female ; Fever ; Humans ; Methotrexate ; Middle Aged ; Pityriasis ; Pityriasis Lichenoides ; Ulcer ; Ultraviolet Therapy

A synthetic analogue of calcitriol (1,25-dihydroxymitamin D3), has shown immunomodulatory effects as well as induction of cell differentiation and inhibition of cell proliferation. This agent has been widely used for psoriasis. We report a case of seborrheic keratosis of the left areola in a 33-year-old female who was treated with calcipotriol ointment. Because of the lesion's location and shape, it was difficult to try ablative methods. However, complete disappearance of the lesion was observed after 6 weeks of topical calcipotriol application. This case suggests that the calcipotriol ointment is effective in the treatment of seborrheic keratosis.
Adult ; Calcitriol ; Cell Differentiation ; Cell Proliferation ; Female ; Humans ; Keratosis, Seborrheic ; Psoriasis

We report a case of tinea incognito in a 29-year-old man after applying the 0.03% tacrolimus ointment. He was known atopic dermatitis patient and has been treated with intermittent application of tacrolimus. For his facial pruritus 0.03% tacrolimus ointment was prescribed, and after one week he developed annularly grouped erythematous plaques and patches around the ointment-applied area. The KOH smear revealed multiple fungal hyphae. Dermatologists should be aware of the possibility of topical tacrolimus to be the causative agent for tinea incognito.
Dermatitis, Atopic ; Hyphae ; Pruritus ; Tacrolimus ; Tinea

Therapeutic options for infantile hemangioma are limited. The nonselective beta-adrenergic receptor antagonist propranolol is an effective therapy for infantile hemangiomas. However, systemic propranolol carries a risk of serious side effects, including bradycardia, hypoglycemia, arrhythmias, hypotension and bronchospasm. Recently, treatment of infantile hemangioma with topical timolol (nonselective beta-blocker similar to propranolol) has been reported. We treated successfully the perineal ulcerative hemangioma with topical timolol. We believe that timolol is a safe and effective topical agent and should be strongly considered as one of good therapeutic options for hemagnioma.
Arrhythmias, Cardiac ; Bradycardia ; Bronchial Spasm ; Hemangioma ; Hypoglycemia ; Hypotension ; Propranolol ; Timolol ; Ulcer

Therapeutic options for infantile hemangioma are limited. The nonselective beta-adrenergic receptor antagonist propranolol is an effective therapy for infantile hemangiomas. However, systemic propranolol carries a risk of serious side effects, including bradycardia, hypoglycemia, arrhythmias, hypotension and bronchospasm. Recently, treatment of infantile hemangioma with topical timolol (nonselective beta-blocker similar to propranolol) has been reported. We treated successfully the perineal ulcerative hemangioma with topical timolol. We believe that timolol is a safe and effective topical agent and should be strongly considered as one of good therapeutic options for hemagnioma.
Arrhythmias, Cardiac ; Bradycardia ; Bronchial Spasm ; Hemangioma ; Hypoglycemia ; Hypotension ; Propranolol ; Timolol ; Ulcer